Photodynamic Therapy for Actinic Keratoses: A Randomized Prospective Non-sponsored Cost-effectiveness Study of Daylight-mediated Treatment Compared with Light-emitting Diode Treatment

Authors

  • Noora Neittaanmäki-Perttu
  • Mari Grönroos
  • Toni Karppinen
  • Erna Snellman
  • Pekka Rissanen

DOI:

https://doi.org/10.2340/00015555-2205

Abstract

Daylight-mediated photodynamic therapy (DL-PDT) is considered as effective as conventional PDT using artificial light (light-emitting diode (LED)-PDT) for treatment of actinic keratoses (AK). This randomized prospective non-sponsored study assessed the cost-effectiveness of DL-PDT compared with LED-PDT. Seventy patients with 210 AKs were randomized to DL-PDT or LED-PDT groups. Effectiveness was assessed at 6 months. The costs included societal costs and private costs, including the time patients spent in treatment. Results are presented as incremental cost-effectiveness ratio (ICER). The total costs per patient were significantly lower for DL-PDT (–132) compared with LED-PDT (–170), giving a cost saving of –38 (p=0.022). The estimated probabilities for patients’ complete response were 0.429 for DL-PDT and 0.686 for LED-PDT; a difference in probability of being healed of 0.257. ICER showed a monetary gain of –147 per unit of effectiveness lost. DL-PDT is less costly and less effective than LED-PDT. In terms of cost-effectiveness analysis, DL-PDT provides lower value for money compared with LED-PDT.

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Published

2015-09-23

How to Cite

Neittaanmäki-Perttu, N., Grönroos, M., Karppinen, T., Snellman, E., & Rissanen, P. (2015). Photodynamic Therapy for Actinic Keratoses: A Randomized Prospective Non-sponsored Cost-effectiveness Study of Daylight-mediated Treatment Compared with Light-emitting Diode Treatment. Acta Dermato-Venereologica, 96(2), 241–244. https://doi.org/10.2340/00015555-2205

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Articles