Factors Associated with Eczema Clinical Trial Awareness, Interest, and Participation in Adults
DOI:
https://doi.org/10.2340/actadv.v103.6520Keywords:
Clinical Trials, Dermatitis, Atopic, Eczema, Health Literacy, Patient Recruitment, Translational Science, BiomedicalAbstract
Despite the need for improved eczema therapies and a rapid increase in available eczema clinical trials, participation remains low. The aim of this study was to identify factors associated with clinical trial awareness, interest, and barriers to enrolment and participation. An online survey, administered 1 May to 6 June 2020 to adults (≥ 18 years) with eczema in the USA, was analysed. Among 800 patients included, mean age was 49.4 years, most respondents were female (78.1%), White (75.4%), non-Hispanic (91.4%), and geographically living in an urban/suburban area (Rural-Urban Continuum Codes (RUCC) 1–3, 90.8%). Only 9.7% of respondents reported previous participation in clinical trials, while 57.1% had considered participation and 33.2% never considered participation. Higher satisfaction with current eczema therapy, clinical trial literacy, and confidence in finding eczema trial information were all associated with clinical trial awareness, interest, and successful participation. Younger age and having atopic dermatitis were associated with increased awareness, while female gender was a barrier to interest and successful participation.
Downloads
References
Nephew LD. Accountability in clinical trial diversity: The buck stops where? EClinicalMedicine 2021; 36: 100906.
https://doi.org/10.1016/j.eclinm.2021.100906 DOI: https://doi.org/10.1016/j.eclinm.2021.100906
Ding J, Zhou Y, Khan MS, Sy RN, Khosa F Representation of sex, race, and ethnicity in pivotal clinical trials for dermatological drugs. Int J Womens Dermatol 2021; 7: 428-434.
https://doi.org/10.1016/j.ijwd.2021.02.007 DOI: https://doi.org/10.1016/j.ijwd.2021.02.007
Administration USD of H&. HSFAD, US Department of Health & Human Services; Food and Drug Administration. Guideline for the study and evaluation of gender differences in the clinical evaluation of drugs; notice. PsycEXTRA Dataset. 1993. [accessed March 1 2022] Available from: https://www.fda.gov/media/75648/download.
McCleary KK. The more than skin deep "voice of the patient" report. [cited 2023 Jun 1]. Available from: https://www.morethanskindeep-eczema.org/uploads/1/2/5/3/125377765/mtsd_report_-_digital_file_1.pdf.
Davis MM, Clark SJ, Butchart AT, Singer DC, Shanley TP, Gipson DS. Public participation in, and awareness about, medical research opportunities in the era of clinical and translational research. Clin Transl Sci 2013; 6: 88-93.
https://doi.org/10.1111/cts.12019 DOI: https://doi.org/10.1111/cts.12019
Patel KR, Silverberg JI. Willingness to participate in atopic dermatitis studies and clinical trails. Dermatitis 2020; 31: e9-e11.
https://doi.org/10.1097/DER.0000000000000487 DOI: https://doi.org/10.1097/DER.0000000000000487
Chu SH, Kim EJ, Jeong SH, Park GL. Factors associated with willingness to participate in clinical trials: a nationwide survey study. BMC Public Health 2015; 15: 10.
https://doi.org/10.1186/s12889-014-1339-0 DOI: https://doi.org/10.1186/s12889-014-1339-0
Peay HL, Biesecker BB, Wilfond BS, Jarecki J, Umstead KL, Escolar DM, Tibben A. Barriers and facilitators to clinical trial participation among parents of children with pediatric neuromuscular disorders. Clin Trials 2018; 15: 139-148.
https://doi.org/10.1177/1740774517751118 DOI: https://doi.org/10.1177/1740774517751118
van de Glind EM, Vural EM, Scholten E, Hooft L, Portegijs E, van Munster BC, et al. Barriers to and facilitators of participation of older adults in a placebo-controlled randomized clinical trial. J Am Geriatr Soc 2013; 61: 1421-1422.
https://doi.org/10.1111/jgs.12388 DOI: https://doi.org/10.1111/jgs.12388
Ellis PM, Butow PN, Tattersall MH, Dunn SM, Houssami N. Randomized clinical trials in oncology: understanding and attitudes predict willingness to participate. J Clin Oncol 2001; 19: 3554-3561.
https://doi.org/10.1200/JCO.2001.19.15.3554 DOI: https://doi.org/10.1200/JCO.2001.19.15.3554
Tohid H, Choudhury SM, Agouba S, Aden A, Ahmed LHM, Omar O, et al. Perceptions and attitudes to clinical research participation in Qatar. Contemp Clin Trials Commun 2017; 8: 241-247.
https://doi.org/10.1016/j.conctc.2017.10.010 DOI: https://doi.org/10.1016/j.conctc.2017.10.010
Joshi V, Kulkarni AA. Public awareness of clinical trials: a qualitative pilot study in Pune. Perspect Clin Res 2012; 3: 125-132.
https://doi.org/10.4103/2229-3485.103593 DOI: https://doi.org/10.4103/2229-3485.103593
USDA Economic Research Service. Rural-Urban Continuum Codes. 2020 [accessed 2022, April 22]. Available from: https://www.ers.usda.gov/dataproducts/rural-urban-continuum-codes.asp.
R Core Team (2023). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.
Hosmer, David W. and Lemeshow, Stanley. Applied logistic regression. John Wiley and Sons, 2000.
https://doi.org/10.1002/0471722146 DOI: https://doi.org/10.1002/0471722146
Anderson A, Borfitz D, Getz K. Global public attitudes about clinical research and patient experiences with clinical trials. JAMA Netw Open 2018; 1: e182969.
https://doi.org/10.1001/jamanetworkopen.2018.2969 DOI: https://doi.org/10.1001/jamanetworkopen.2018.2969
Lara PN Jr, Paterniti DA, Chiechi C, Turrell C, Morain C, Horan N, et al. Evaluation of factors affecting awareness of and willingness to participate in cancer clinical trials. J Clin Oncol 2005; 23: 9282-9289.
https://doi.org/10.1200/JCO.2005.02.6245 DOI: https://doi.org/10.1200/JCO.2005.02.6245
Mackenzie IS, Wei L, Rutherford D, Findlay EA, Saywood W, Campbell MK, Macdonald TM. Promoting public awareness of randomised clinical trials using the media: the "Get Randomised" campaign. Br J Clin Pharmacol 2010; 69: 128-135.
https://doi.org/10.1111/j.1365-2125.2009.03561.x DOI: https://doi.org/10.1111/j.1365-2125.2009.03561.x
Johnson JK, Loiselle A, Thibau IJ, Smith Begolka W. Factors related to eczema clinical trial participation among adult patients and caregivers. Contemp Clin Trials Commun 2023 33: 101138.
https://doi.org/10.1016/j.conctc.2023.101138 DOI: https://doi.org/10.1016/j.conctc.2023.101138
Additional Files
Published
How to Cite
License
Copyright (c) 2023 Erin E. Grinich, Isabelle J. Thibau, Emile Latour, Kyla N. Price, Allison R. Loiselle, Eric Simpson, Wendy Smith Begolka
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
