HLA-DR-antigen bearing keratinocytes in various dermatologic disorders
DOI:
https://doi.org/10.2340/0001555565913Abstract
In normal human epidermis HLA-DR-antigen is only present on Langerhans´ cells and the acrosyringeal epithelium. We investigated the distribution of HLA-DR-antigen in 78 specimens of various skin diseases by an immunoperoxidase method using a monoclonal anti-HLA-DR antibody. HLA-DR-antigen bearing keratinocytes were not only found in lichen planus and mycosis fungoides, as it has been referred previously, but were also observed in some cases of cutaneous B-cell lymphoma, pseudolymphoma, lupus erythematosus, parapsoriasis en plaque, bullous pemphigoid, drug reaction, contact dermatitis, actinic keratosis and verrucous carcinoma. Direct contact of lymphoid cells with keratinocytes was not necessary for Ia-antigen expression.Downloads
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Published
1985-01-01
How to Cite
Smolle, J. (1985). HLA-DR-antigen bearing keratinocytes in various dermatologic disorders. Acta Dermato-Venereologica, 65(1), 9–13. https://doi.org/10.2340/0001555565913
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Copyright (c) 1985 Acta Dermato-VenereologicaAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
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