Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin
DOI:
https://doi.org/10.2340/0001555565409412Abstract
Cutaneous pruritic effects of synthetic platelet activating factor (PAF-acether) and, in particular, its interference with dermal mast cells, were studied in human volunteers. Intradermal injections of 10-100 ng produced dose-dependent flare and itching responses. The cutaneous reactions were inhibited by local administration of the H1 antihistamine mepyramin. The cutaneous responses were also markedly reduced in histamine-depleted skin. These findings indicate that the cutaneous responses produced by PAF-acether were mediated via an indirect and mainly histamine-dependent mechanism.Downloads
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Published
1985-09-01
How to Cite
Fjellner, B., & Hägermark, O. (1985). Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. Acta Dermato-Venereologica, 65(5), 409–412. https://doi.org/10.2340/0001555565409412
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Copyright (c) 1985 Acta Dermato-VenereologicaAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
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