Glycosaminoglycan alteration in the skin of children with classical Ehlers-Danlos syndrome
DOI:
https://doi.org/10.2340/0001555565489494Abstract
Three children with classical Ehlers-Danlos syndrome were studied. Electron microscopic observation of the skin demonstrated a hyaluronic acid-dominant glycosaminoglycan structure in the intercellular matrix. Biochemical analysis showed a significant increase in hyaluronic acid content, as compared with the skin of sex- and age-matched children, including a non-affected brother of a patient. In addition, enhanced hyaluronic acid synthesis was demonstrated in vitro, using a patient´s dermal fibroblasts. Analysis of the collagen showed no apparent abnormalities.Downloads
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Published
1985-11-01
How to Cite
Yamakage, A., Uchiyama, Y., Nihei, Y., & Ishikawa, H. (1985). Glycosaminoglycan alteration in the skin of children with classical Ehlers-Danlos syndrome. Acta Dermato-Venereologica, 65(6), 489–494. https://doi.org/10.2340/0001555565489494
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Copyright (c) 1985 Acta Dermato-VenereologicaAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
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