Minimal effect of complete H1 receptor blockade on urticaria pigmentosa

Authors

  • LB Krause
  • S. Shuster

DOI:

https://doi.org/10.2340/0001555565338340

Abstract

The effect of complete H1 receptor blockade on urticaria pigmentosa was studied in 6 patients. Astemizole 10 mg tds was given for 6 weeks to achieve complete H1 receptor blockade and the response measured by change in force-weal response measurements using two different forces on a dermographic stylus and measuring response as weal diameter. Weal and flare reactions to 8 micrograms histamine were completely abolished by the astemizole but dermographic weal-force responses were reduced only by 12-15% indicating that histamine acting at the H1 receptor plays only a small part in the wealing of urticaria pigmentosa.

Downloads

Download data is not yet available.

Downloads

Published

1985-07-01

How to Cite

Krause, L., & Shuster, S. (1985). Minimal effect of complete H1 receptor blockade on urticaria pigmentosa. Acta Dermato-Venereologica, 65(4), 338–340. https://doi.org/10.2340/0001555565338340

Issue

Section

Articles