Severe Pneumonia Caused by Combined Infection with Pneumocystis jiroveci, Parainfluenza Virus Type 3, Cytomegalovirus, and Aspergillus fumigatus in a Patient with Stevens-Johnson Syndrome/toxic Epidermal Necrolysis

Authors

  • Taehoon Lee
  • Yun-Jeong Bae
  • Soo-Kyung Park
  • Hyun Jung Park
  • Sung-Han Kim
  • You Sook Cho
  • Hee-Bom Moon
  • Sang-Oh Lee
  • Tae-Bum Kim

DOI:

https://doi.org/10.2340/00015555-0977

Keywords:

Stevens-Johnson syndrome, toxic epidermal necrolysis, corticosteroid, pneumonia, infection.

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We report here the first case of severe pneumonia caused by an unusual combined infection with Pneumocystis carinii (jiroveci), parainfluenza virus type 3, cytomegalovirus and Aspergillus fumigatus in a 63-year-old female patient with allopurinol-induced SJS/TEN overlap syndrome. Following treatment with high-dose systemic corticosteroids and intravenous immunoglobulin for SJS/TEN, her mucocutaneous lesions improved and she was due to be discharged. However, 15 days after cessation of corticosteroids, she developed pneumonia. Broncho­alveolar lavage revealed that the cause of infection was Pneumocystis carinii (jiroveci), parainfluenza virus type 3, cytomegalovirus and Aspergillus. These findings indicate that patients with SJS/TEN, particularly those treated with systemic corticosteroids, may be susceptible to infection with combinations of pathological agents resulting from damage to the bronchial epithelia.

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Published

2010-09-22

How to Cite

Lee, T., Bae, Y.-J., Park, S.-K., Jung Park, H., Kim, S.-H., Sook Cho, Y., … Kim, T.-B. (2010). Severe Pneumonia Caused by Combined Infection with Pneumocystis jiroveci, Parainfluenza Virus Type 3, Cytomegalovirus, and Aspergillus fumigatus in a Patient with Stevens-Johnson Syndrome/toxic Epidermal Necrolysis. Acta Dermato-Venereologica, 90(6), 625–629. https://doi.org/10.2340/00015555-0977

Issue

Section

Articles