Sex Differences in Health-related Quality of Life in Patients with Keratinocyte Carcinomas

Authors

  • Francesca Sampogna IDI-IRCCS (Istituto Dermopatico dell’Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico, Dermatological Research Hospital), Via Monti di Creta 104, IT-00167 Rome, Italy
  • Andrea Paradisi
  • Maria Luisa Iemboli
  • Luca Fania
  • Francesco Ricci
  • Monica Napolitano
  • Damiano Abeni

DOI:

https://doi.org/10.2340/00015555-3736

Keywords:

sex, health status, keratinocyte carcinoma, non-melanoma skin cancer, quality of life

Abstract

The difference between men and women in the impact of keratinocyte carcinomas on quality of life has not been widely studied. This study of 364 patients with keratinocyte carcinoma, measured quality of life using the self-administered 12-item Short Form Health Survey (SF-12) and Skindex-29. Results for both the physical and the mental components of SF-12 were worse in women than in men. For the mental component, women had significantly lower scores compared with men in almost all subgroups, based on demographic and clinical variables. The Skindex-29 emotions mean score was worse in women than in men. Women reported significantly higher level of worry that the disease could get worse and of developing scars, and more depression. On the other hand, men reported lower quality of sleep. The impact of keratinocyte carcinomas on quality of life is generally higher in women than in men. Such data may be important for tailored management of the disease in different categories of patients.

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References

Leiter U, Eigentler T, Garbe C. Epidemiology of skin cancer BT - sunlight, vitamin D and skin cancer. In: Reichrath J, editor. Adv Exp Med Biol 2014; 810: 120-140.

DOI: https://doi.org/10.1007/978-1-4939-0437-2_7

Karimkhani C, Boyers LN, Dellavalle RP, Weinstock MA. It's time for "keratinocyte carcinoma" to replace the term "nonmelanoma skin cancer." J Am Acad Dermatol 2015; 72: 186-187.

DOI: https://doi.org/10.1016/j.jaad.2014.09.036

Asgari MM, Moffet HH, Ray GT, Quesenberry CP. Trends in basal cell carcinoma incidence and identification of high-risk subgroups, 1998-2012. JAMA Dermatology 2015; 151: 976-981.

DOI: https://doi.org/10.1001/jamadermatol.2015.1188

Nehal KS, Bichakjian CK. Update on keratinocyte carcinomas. N Engl J Med 2018; 379: 363-374.

DOI: https://doi.org/10.1056/NEJMra1708701

Wang J, Aldabagh B, Yu J, Arron ST. Role of human papillomavirus in cutaneous squamous cell carcinoma: a meta-analysis. J Am Acad Dermatol 2014; 70: 621-629.

DOI: https://doi.org/10.1016/j.jaad.2014.01.857

Madan V, Lear JT, Szeimies RM. Non-melanoma skin cancer. Lancet 2010; 375: 673-685.

DOI: https://doi.org/10.1016/S0140-6736(09)61196-X

Blackford S, Roberts D, Salek MS, Finlay A. Basal cell carcinomas cause little handicap. Qual Life Res 1996; 5: 191-194.

DOI: https://doi.org/10.1007/BF00434740

Rhee JS, Matthews BA, Neuburg M, Smith TL, Burzynski M, Nattinger AB. Skin cancer and quality of life: assessment with the Dermatology Life Quality Index. Dermatologic Surg 2004; 30: 525-529.

DOI: https://doi.org/10.1097/00042728-200404000-00013

Sampogna F, Tabolli S, Abeni D. Impact of different skin conditions on quality of life. G Ital Di Dermatologia e Venereol 2013; 148: 255-261.

Gaulin C, Sebaratnam DF, Fernández-Peñas P. Quality of life in non-melanoma skin cancer. Australas J Dermatol 2015; 56: 70-76.

DOI: https://doi.org/10.1111/ajd.12205

Sampogna F, Paradisi A, Iemboli ML, Ricci F, Sonego G, Abeni D. Comparison of quality of life between melanoma and non-melanoma skin cancer patients. Eur J Dermatology 2019; 29: 185-191.

Philipp-Dormston WG, Müller K, Novak B, Strömer K, Termeer C, Hammann U, et al. Patient-reported health outcomes in patients with non-melanoma skin cancer and actinic keratosis: results from a large-scale observational study analysing effects of diagnoses and disease progression. J Eur Acad Dermatology Venereol 2018; 32: 1138-1146.

DOI: https://doi.org/10.1111/jdv.14703

Regitz-Zagrosek V. Sex and gender differences in health. Science & Society Series on Sex and Science. EMBO Rep 2012; 13: 596-603.

DOI: https://doi.org/10.1038/embor.2012.87

Flohil SC, Seubring I, Van Rossum MM, Coebergh JWW, De Vries E, Nijsten T. Trends in basal cell carcinoma incidence rates: a 37-year Dutch observational study. J Invest Dermatol 2013; 133: 913-918.

DOI: https://doi.org/10.1038/jid.2012.431

Oberyszyn TM. Non-melanoma skin cancer: importance of gender, immunosuppressive status and vitamin D. Cancer Lett 2008; 261: 127-136.

DOI: https://doi.org/10.1016/j.canlet.2008.01.009

Xiang F, Lucas R, Hales S, Neale R. Incidence of nonmelanoma skin cancer in relation to ambient UV radiation in white populations, 1978-2012 empirical relationships. JAMA Dermatology 2014; 150: 1063-1071.

DOI: https://doi.org/10.1001/jamadermatol.2014.762

Heaton H, Lawrence N. Nonmelanoma skin cancer in women. Int J Women's Dermatology 2019; 5: 2-7.

DOI: https://doi.org/10.1016/j.ijwd.2018.08.007

Demers AA, Nugent Z, Mihalcioiu C, Wiseman MC, Kliewer EV. Trends of nonmelanoma skin cancer from 1960 through 2000 in a Canadian population. J Am Acad Dermatol 2005; 53: 320-328.

DOI: https://doi.org/10.1016/j.jaad.2005.03.043

Moser U, Andrianakis A, Pondorfer P, Wolf A, Graupp M, Weiland T, et al. Sex-specific differences in patients with nonmelanoma skin cancer of the pinna. Head Neck 2020; 42: 2414-2420.

DOI: https://doi.org/10.1002/hed.26237

Lewis KG, Weinstock MA. Trends in nonmelanoma skin cancer mortality rates in the United States, 1969 through 2000. J Invest Dermatol 2007; 127: 2323-2327.

DOI: https://doi.org/10.1038/sj.jid.5700897

Zachariae R, Zachariae C, Ibsen HHW, Mortensen JT, Wulf HC. Psychological symptoms and quality of life of dermatology outpatients and hospitalized dermatology patients. Acta Derm Venereol 2004; 84: 205-212.

DOI: https://doi.org/10.1080/00015550410023284

Sampogna F, Chren MM, Melchi CF, Pasquini P, Tabolli S, Abeni D. Age, gender, quality of life and psychological distress in patients hospitalized with psoriasis. Br J Dermatol 2006; 154: 325-331.

DOI: https://doi.org/10.1111/j.1365-2133.2005.06909.x

Abedini R, Nasimi M, Noormohammad Pour P, Moghtadaie A, Tohidinik HR. Quality of life in patients with non-melanoma skin cancer: implications for healthcare education services and supports. J Cancer Educ 2019; 34: 755-759.

DOI: https://doi.org/10.1007/s13187-018-1368-y

Harlow D, Poyner T, Finlay AY, Dykes PJ. Impaired quality of life of adults with skin disease in primary care. Br J Dermatol 2000; 143: 979-982.

DOI: https://doi.org/10.1046/j.1365-2133.2000.03830.x

National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines), basal cell skin cancers 2020: Version 1.2020. (accessed 2020 June 30). Available from: https://www.nccn.org/professionals/physician_gls/pdf/nmsc.pdf.

National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines), squamous cell skin cancers 2020: Version 1.2020. (accessed 2020 June 30). Available from: https: //www.nccn.org/professionals/physician_gls/pdf/squamous.pdf.

Ware JE, Kosinksi M, Turner-Bowker DM, Gandek B, editors. User's manual for the SF-12v2 Health survey with a supplement documenting SF-12 Health Survey. Lincoln, RI: QualityMetric Incorporated; 2002.

Ware J, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996; 34: 220-233.

DOI: https://doi.org/10.1097/00005650-199603000-00003

Chren MM, Lasek RJ, Flocke SA, Zyzanski SJ. Improved discriminative and evaluative capability of a refined version of Skindex, a quality of life instrument for patients with skin diseases. Arch Dermatol 1997; 133: 1433-1440.

DOI: https://doi.org/10.1001/archderm.1997.03890470111018

Goldberg D. The detection of psychiatric illness by questionnaire. London: Oxford University Press; 1972.

Picardi A, Abeni D, Mazzotti E, Fassone G, Lega I, Ramieri L, et al. Screening for psychiatric disorders in patients with skin diseases. J Psychosom Res 2004; 57: 219-223.

DOI: https://doi.org/10.1016/S0022-3999(03)00619-6

Berg M, Lindberg M. Possible gender differences in the quality of life and choice of therapy in acne. J Eur Acad Dermatol Venereol 2011; 25: 969-972.

DOI: https://doi.org/10.1111/j.1468-3083.2010.03907.x

Shi Q, Duvic M, Osei JS, Hordinsky MK, Norris DA, Price VH, et al. Health-related quality of life (HRQoL) in alopecia areata patients - a secondary analysis of the National Alopecia Areata Registry Data. J Investig Dermatol Symp Proc 2013; 16: S49-S50.

DOI: https://doi.org/10.1038/jidsymp.2013.18

Rees JR, Zens MS, Celaya MO, Riddle BL, Karagas MR, Peacock JL. Survival after squamous cell and basal cell carcinoma of the skin: a retrospective cohort analysis. Int J Cancer 2015; 137: 878-884.

DOI: https://doi.org/10.1002/ijc.29436

Jensen AØ, Lamberg AL, Jacobsen JB, Olesen AB, Sørensen HT. Non-melanoma skin cancer and ten-year all-cause mortality: a population-based cohort study. Acta Derm Venereol 2010; 90: 362-367.

DOI: https://doi.org/10.2340/00015555-0899

Hawkins DM, Jacobsen G, Johnson CC, Lim HW, Eide MJ. Self-reported quality of life after skin cancer in young adults. J Dermatolog Treat 2015; 26: 357-360.

DOI: https://doi.org/10.3109/09546634.2014.991671

Rhee JS, Loberiza FR, Matthews BA, Neuburg M, Smith TL, Burzynski M. Quality of life assessment in nonmelanoma cervicofacial skin cancer. Laryngoscope 2003; 113: 215-220.

DOI: https://doi.org/10.1097/00005537-200302000-00004

Asgari MM, Bertenthal D, Sen S, Sahay A, Chren MM. Patient satisfaction after treatment of nonmelanoma skin cancer. Dermatologic Surg 2009; 35: 1041-1049.

DOI: https://doi.org/10.1111/j.1524-4725.2009.01181.x

Chren MM, Sahay AP, Bertenthal DS, Sen S, Landefeld CS. Quality of life outcomes of treatments for cutaneous basal cell carcinoma and squamous cell carcinoma. J Invest Dermatol 2007; 127: 1351-1357.

DOI: https://doi.org/10.1038/sj.jid.5700740

Chen T, Bertenthal D, Sahay A, Sen S, Chren MM. Predictors of skin-related quality of life after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. Arch Dermatol 2007; 143: 1386-1392.

DOI: https://doi.org/10.1001/archderm.143.11.1386

Villani A, Fabbrocini G, Cappello M, Costa C, Scalvenzi M. Real-life effectiveness of vismodegib in patients with metastatic and advanced basal cell carcinoma: characterization of adverse events and assessment of health-related quality of life using the Dermatology Life Quality Index (DLQI) test. Dermatol Ther (Heidelb) 2019; 9: 505-510.

DOI: https://doi.org/10.1007/s13555-019-0303-4

Chernyshov PV, Lallas A, Tomas-Aragones L, Arenbergerova M, Samimi M, Manolache L, et al. Quality of life measurement in skin cancer patients: literature review and position paper of the European Academy of Dermatology and Venereology Task Forces on Quality of life and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer. J Eur Acad Dermatol Venereol 2019; 33: 816-827.

DOI: https://doi.org/10.1111/jdv.15487

Published

2021-04-27

How to Cite

Sampogna, F., Paradisi, A., Iemboli, M. L., Fania, L., Ricci, F., Napolitano, M., & Abeni, D. (2021). Sex Differences in Health-related Quality of Life in Patients with Keratinocyte Carcinomas. Acta Dermato-Venereologica, 101(4), adv00439. https://doi.org/10.2340/00015555-3736