Hyperkeratosis lenticularis perstans (Flegel´s disease)
DOI:
https://doi.org/10.2340/0001555563357360Abstract
A 62-year-old female with a 20-year history of small horny papules on the skin of the legs is described. Light microscopy revealed a hyperkeratotic papule with atrophic epidermis and a dense dermal inflammatory cell infiltrate with many cerebriform lymphocytes not earlier described in connection with hyperkeratosis lenticularis perstans (HLP). The electron-microscopic picture showed membrane-coating granules (MCG) and keratohyalin located in different cells, indicating that the disorder of keratinization in HLP is possibly caused by reduced co-operation between these cells and that the keratinization process occurs in the absence of MCG. Perpetual treatment with oral retinoid was successful.Downloads
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Published
1983-07-01
How to Cite
Kuokkanen, K., Alavaikko, M., & Pitkänen, R. (1983). Hyperkeratosis lenticularis perstans (Flegel´s disease). Acta Dermato-Venereologica, 63(4), 357–360. https://doi.org/10.2340/0001555563357360
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