Sustained CD19+CD27+ Memory B Cell Depletion after Rituximab Treatment in Patients with Pemphigus Vulgaris

Authors

  • Katharina Boch
  • Ewan A. Langan
  • Enno Schmidt
  • Detlef Zillikens
  • Ralf J. Ludwig
  • Katja Bieber
  • Christoph M. Hammers Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, DE-23562 Lübeck, Germany

DOI:

https://doi.org/10.2340/actadv.v102.907

Keywords:

Pemphigus, Rituximab, Therapy, Immunosuppression, SARS-CoV2, COVID-19

Abstract

Abstract is missing (Short communication)

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References

Kasperkiewicz M, Ellebrecht CT, Takahashi H, Yamagami J, Zillikens D, Payne AS, et al. Pemphigus. Nat Rev Dis Primers 2017; 3: 17026.

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Schmidt E, Kasperkiewicz M, Joly P. Pemphigus. Lancet 2019; 394: 882-894.

https://doi.org/10.1016/S0140-6736(19)31778-7

Joly P, Horvath B, Patsatsi Α, Uzun S, Bech R, Beissert S, et al. Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 2020; 34: 1900-1913.

https://doi.org/10.1111/jdv.16752

Joly P, Maho-Vaillant M, Prost-Squarcioni C, Hebert V, Houivet E, Calbo S, et al. First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial. Lancet 2017; 389: 2031-2040.

https://doi.org/10.1016/S0140-6736(17)30070-3

Colliou N, Picard D, Caillot F, Calbo S, Le Corre S, Lim A, et al. Long-term remissions of severe pemphigus after rituximab therapy are associated with prolonged failure of desmoglein B cell response. Sci Transl Med 2013; 5: 175ra30.

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https://doi.org/10.1182/blood-2010-01-266668

Schmidt E, Goebeler M, Hertl M, Sárdy M, Sitaru C, Eming R, et al. S2k guideline for the diagnosis of pemphigus vulgaris/foliaceus and bullous pemphigoid. J Dtsch Dermatol Ges 2015; 13: 713-727.

https://doi.org/10.1111/ddg.12612

Daniel BS, Hertl M, Werth VP, Eming R, Murrell DF. Severity score indexes for blistering diseases. Clin Dermatol 2012; 30: 108-113.

https://doi.org/10.1016/j.clindermatol.2011.03.017

Isolation of mononuclear cells from human peripheral blood by density gradient centrifugation. [accessed 2022 Feb 14] Available from: https://www.miltenyibiotec.com/_Resources/Persistent/6d7e0fb8a3eab613958d142051e3c7050eb0c8a9/SP_MC_PB_density_gradient.pdf.

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Published

2022-03-25

How to Cite

Boch, K., Langan, E. A., Schmidt, E., Zillikens, D., Ludwig, R. J., Bieber, K., & Hammers, C. M. (2022). Sustained CD19+CD27+ Memory B Cell Depletion after Rituximab Treatment in Patients with Pemphigus Vulgaris. Acta Dermato-Venereologica, 102, adv00679. https://doi.org/10.2340/actadv.v102.907

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