Impact of Type 1 Versus Type 2 Diabetes on Developing Herpes Zoster and Post-herpetic Neuralgia: A Population-based Cohort Study
DOI:
https://doi.org/10.2340/actadv.v103.9400Keywords:
herpes zoster, post-herpetic neuralgia, type 1 diabetes mellitus, type 2 diabetes mellitus, VaccinesAbstract
Type 2 diabetes is associated with an increased risk of herpes zoster and postherpetic neuralgia. However, the association of type 1 diabetes with herpes zoster or postherpetic neuralgia remains unclear. This retrospective cohort study using Taiwan’s Health Insurance Research Database included 199,566 patients with type 1 diabetes and 1,458,331 with type 2 diabetes, identified during the period 2000 to 2012. Patients with type 1 diabetes had a significantly higher risk of developing herpes zoster than those with type 2 diabetes (p < 0.001). Across all age groups, the impact of diabetes on herpes zoster was greater in type 1 than in type 2 diabetes. Patients with both type 1 and type 2 diabetes had a 1.45-fold higher risk of post-herpetic neuralgia than those without diabetes (hazard ratio 1.45, 95% confidence interval 1.28–1.65; hazard ratio 1.45, 95% confidence interval 1.37–1.52, respectively), and there was no difference between the 2 types of diabetes (hazard ratio 1.06; 95% confidence interval 0.93–1.21). The results recommend consideration of herpes zoster vaccination at an earlier age in patients with type 1 diabetes.
Downloads
References
Speight J, Holmes-Truscott E, Hendrieckx C, Skovlund S, Cooke D. Assessing the impact of diabetes on quality of life: what have the past 25 years taught us? Diabet Med 2020; 37: 483-492.
https://doi.org/10.1111/dme.14196 DOI: https://doi.org/10.1111/dme.14196
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract 2019; 157: 107843.
https://doi.org/10.1016/j.diabres.2019.107843 DOI: https://doi.org/10.1016/j.diabres.2019.107843
Casqueiro J, Casqueiro J, Alves C. Infections in patients with diabetes mellitus: a review of pathogenesis. Indian J Endocrinol Metab 2012; 16: S27-S36.
https://doi.org/10.4103/2230-8210.94253 DOI: https://doi.org/10.4103/2230-8210.94253
Carey IM, Critchley JA, DeWilde S, Harris T, Hosking FJ, Cook DG. Risk of infection in type 1 and type 2 diabetes compared with the general population: a matched cohort study. Diabetes Care 2018; 41: 513-521.
https://doi.org/10.2337/dc17-2131 DOI: https://doi.org/10.2337/dc17-2131
Sampathkumar P, Drage LA, Martin DP. Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clin Proc 2009; 84: 274-280.
https://doi.org/10.4065/84.3.274 DOI: https://doi.org/10.4065/84.3.274
Sengupta N, Breuer J. A global perspective of the epidemiology and burden of varicella-zoster virus. Curr Pediatr Rev 2009; 5: 207-228.
https://doi.org/10.2174/157339609791317315 DOI: https://doi.org/10.2174/157339609791317315
Yawn BP, Saddier P, Wollan PC, St Sauver JL, Kurland MJ, Sy LS. A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc 2007; 82: 1341-1349.
https://doi.org/10.4065/82.11.1341 DOI: https://doi.org/10.4065/82.11.1341
Harpaz R, Ortega-Sanchez IR, Seward JF. Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2008; 57: 1-30.
Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open 2014; 4: e004833.
https://doi.org/10.1136/bmjopen-2014-004833 DOI: https://doi.org/10.1136/bmjopen-2014-004833
Gershon AA, Gershon MD, Breuer J, Levin MJ, Oaklander AL, Griffiths PD. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. J Clin Virol 2010; 48: S2-S7.
https://doi.org/10.1016/S1386-6532(10)70002-0 DOI: https://doi.org/10.1016/S1386-6532(10)70002-0
Oster G, Harding G, Dukes E, Edelsberg J, Cleary PD. Pain, medication use, and health-related quality of life in older persons with postherpetic neuralgia: results from a population-based survey. J Pain 2005; 6: 356-363.
https://doi.org/10.1016/j.jpain.2005.01.359 DOI: https://doi.org/10.1016/j.jpain.2005.01.359
Gater A, Uhart M, McCool R, Préaud E. The humanistic, economic and societal burden of herpes zoster in Europe: a critical review. BMC Public Health 2015; 15: 193.
https://doi.org/10.1186/s12889-015-1514-y DOI: https://doi.org/10.1186/s12889-015-1514-y
Alper BS, Lewis PR. Treatment of postherpetic neuralgia: a systematic review of the literature. J Fam Pract 2002; 51: 121-128.
Arvin AM, Moffat JF, Redman R. Varicella-zoster virus: aspects of pathogenesis and host response to natural infection and varicella vaccine. Adv Virus Res 1996; 46: 263-309.
https://doi.org/10.1016/S0065-3527(08)60074-3 DOI: https://doi.org/10.1016/S0065-3527(08)60074-3
Kawai K, Yawn BP. Risk factors for herpes zoster: a systematic review and meta-analysis. Mayo Clin Proc 2017; 92: 1806-1821.
https://doi.org/10.1016/j.mayocp.2017.10.009 DOI: https://doi.org/10.1016/j.mayocp.2017.10.009
Forbes HJ, Thomas SL, Smeeth L, Clayton T, Farmer R, Bhaskaran K, et al. A systematic review and meta-analysis of risk factors for postherpetic neuralgia. Pain 2016; 157: 30-54.
https://doi.org/10.1097/j.pain.0000000000000307 DOI: https://doi.org/10.1097/j.pain.0000000000000307
Lim AKH. Diabetic nephropathy - complications and treatment. Int J Nephrol Renovasc Dis 2014; 7: 361-381.
https://doi.org/10.2147/IJNRD.S40172 DOI: https://doi.org/10.2147/IJNRD.S40172
Bruckenthal P, Barkin RL. Options for treating postherpetic neuralgia in the medically complicated patient. Ther Clin Risk Manag 2013; 9: 329-340.
https://doi.org/10.2147/TCRM.S47138 DOI: https://doi.org/10.2147/TCRM.S47138
Torcel-Pagnon L, Bricout H, Bertrand I, Perinetti E, Franco E, Gabutti G, et al. Impact of underlying conditions on zoster-related pain and on quality of life following zoster. J Gerontol A Biol Sci Med Sci 2017; 72: 1091-1097.
https://doi.org/10.1093/gerona/glw189 DOI: https://doi.org/10.1093/gerona/glw189
Schmader KE. Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. Clin J Pain 2002; 18: 350-354.
https://doi.org/10.1097/00002508-200211000-00002 DOI: https://doi.org/10.1097/00002508-200211000-00002
Guignard AP, Greenberg M, Lu C, Rosillon D, Vannappagari V. Risk of herpes zoster among diabetics: a matched cohort study in a US insurance claim database before introduction of vaccination, 1997-2006. Infection 2014; 42: 729-735.
https://doi.org/10.1007/s15010-014-0645-x DOI: https://doi.org/10.1007/s15010-014-0645-x
Ogunjimi B, Buntinx F, Bartholomeeusen S, Terpstra I, De Haes I, Willem L, et al. Herpes zoster is associated with herpes simplex and other infections in under 60-year-olds. J Infect 2015; 70: 171-177.
https://doi.org/10.1016/j.jinf.2014.08.016 DOI: https://doi.org/10.1016/j.jinf.2014.08.016
Forbes HJ, Bhaskaran K, Thomas SL, Smeeth L, Clayton T, Langan SM. Quantification of risk factors for herpes zoster: population-based case-control study. BMJ 2014; 348: g2911.
https://doi.org/10.1136/bmj.g2911 DOI: https://doi.org/10.1136/bmj.g2911
Forbes HJ, Bhaskaran K, Thomas SL, Smeeth L, Clayton T, Mansfield K, et al. Quantification of risk factors for postherpetic neuralgia in herpes zoster patients: a cohort study. Neurology 2016; 87: 94-102.
https://doi.org/10.1212/WNL.0000000000002808 DOI: https://doi.org/10.1212/WNL.0000000000002808
Klompas M, Kulldorff M, Vilk Y, Bialek SR, Harpaz R. Herpes zoster and postherpetic neuralgia surveillance using structured electronic data. Mayo Clin Proc 2011; 86: 1146-1153.
https://doi.org/10.4065/mcp.2011.0305 DOI: https://doi.org/10.4065/mcp.2011.0305
Chen HH, Lin IC, Chen HJ, Yeh SY, Kao CH. Association of herpes zoster and type 1 diabetes mellitus PLoS One 2016; 11: e0155175.
https://doi.org/10.1371/journal.pone.0155175 DOI: https://doi.org/10.1371/journal.pone.0155175
Ke CC, Lai HC, Lin CH, Hung CJ, Chen DY, Sheu WH, et al. Increased risk of herpes zoster in diabetic patients comorbid with coronary artery disease and microvascular disorders: a population-based study in Taiwan. PLoS One 2016; 11: e0146750.
https://doi.org/10.1371/journal.pone.0146750 DOI: https://doi.org/10.1371/journal.pone.0146750
Suaya JA, Chen SY, Li Q, Burstin SJ, Levin MJ. Incidence of herpes zoster and persistent post-zoster pain in adults with or without diabetes in the United States. Open Forum Infect Dis 2014; 1: ofu049.
https://doi.org/10.1093/ofid/ofu049 DOI: https://doi.org/10.1093/ofid/ofu049
Pedicino D, Liuzzo G, Trotta F, Giglio AF, Giubilato S, Martini F, et al. Adaptive immunity, inflammation,and cardiovascular complications in type 1 and type 2 diabetes mellitus. J Diabetes Res 2013; 2013: 184258.
https://doi.org/10.1155/2013/184258 DOI: https://doi.org/10.1155/2013/184258
Okamoto S, Hata A, Sadaoka K, Yamanishi K, Mori Y. Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals. J Infect Dis 2009; 200: 1606-1610.
https://doi.org/10.1086/644646 DOI: https://doi.org/10.1086/644646
Galiero R, Caturano A, Vetrano E, Beccia D, Brin C, Alfano M, et al. Peripheral neuropathy in diabetes mellitus: pathogenetic mechanisms and diagnostic options. Int J Mol Sci 2023; 24: 3554.
https://doi.org/10.3390/ijms24043554 DOI: https://doi.org/10.3390/ijms24043554
Ma WT, Gao F, Gu K, Chen DK. The Role of Monocytes and Macrophages in Autoimmune Diseases: a Comprehensive Review. Front Immunol 2019; 10: 1140.
https://doi.org/10.3389/fimmu.2019.01140 DOI: https://doi.org/10.3389/fimmu.2019.01140
Ohno Y, Aoki N, Nishimura A. In vitro production of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1993; 77: 1072-1077.
https://doi.org/10.1210/jcem.77.4.8408455 DOI: https://doi.org/10.1210/jcem.77.4.8408455
Hsieh CY, Su CC, Shao SC, Sung SF, Lin SJ, Kao Yang YH, et al. Taiwan's National Health Insurance Research Database: past and future. Clin Epidemiol 2019; 11: 349-358.
https://doi.org/10.2147/CLEP.S196293 DOI: https://doi.org/10.2147/CLEP.S196293
Kreng VB, Yang CT. The equality of resource allocation in health care under the National Health Insurance System in Taiwan. Health Policy 2011; 100: 203-210.
https://doi.org/10.1016/j.healthpol.2010.08.003 DOI: https://doi.org/10.1016/j.healthpol.2010.08.003
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Su-Ying Wen, Chao Ou-Yang, Catherine Chang, Chu-Chieh Chen , Hung-Yu Chang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
