Acute Variegate Porphyria in a Professional Bodybuilder after Starting a High-protein Diet and Treatment with Testosterone

Authors

  • Christiane S. Cussigh
  • Nina Trenkler
  • Jochen H.O. Hoffmann
  • Alexander H. Enk
  • Anke S. Lonsdorf Department of Dermatology, University Hospital, Ruprecht-Karls-University of Heidelberg, DE-69120 Heidelberg, Germany

DOI:

https://doi.org/10.2340/00015555-3769

Keywords:

porphyria, variegate porphyria, diet, heme biosynthesis

Abstract

Abstract is missing (Short communication)

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References

Anderson KE, Bloomer JR, Bonkovsky H, Kushner JP, Pierach CA, Pimstone NR, et al. Recommendations for the diagnosis and treatment of the acute porphyrias. Ann Intern Med 2005; 142: 439-450.

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Balwani M, Desnick RJ. The porphyrias: advances in diagnosis and treatment. Blood 2012; 120: 4496-4504.

DOI: https://doi.org/10.1182/blood-2012-05-423186

Siegesmund M, van Tuyll van Serooskerken AM, Poblete-Gutiérrez P, Frank J. The acute hepatic porphyrias: current status and future challenges. Best Pract Res Clin Gastroenterol 2010; 24: 593-605.

DOI: https://doi.org/10.1016/j.bpg.2010.08.010

Stölzel U, Doss MO, Schuppan D. Clinical guide and update on porphyrias. Gastroenterology 2019; 157: 365-381.

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Bonkovsky HL, Dixon N, Rudnick S. Pathogenesis and clinical features of the acute hepatic porphyrias (AHPs). Mol Genet Metab 2019; 128: 213-218.

DOI: https://doi.org/10.1016/j.ymgme.2019.03.002

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Cuny JF. Porphyries cutanées. Ann Dermatol Venereol 2019; 146: 143-159.

DOI: https://doi.org/10.1016/j.annder.2018.12.005

Philipps JD. Heme biosynthesis and the porphyrias. Mol Genet Metab 2019; 128: 164-177.

DOI: https://doi.org/10.1016/j.ymgme.2019.04.008

Singal AK, Anderson KE. Variegate porphyria. 2013 Feb 14 [updated 2019 Dec 12]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, et al. GeneReviews®. Seattle, WA: University of Washington, Seattle; 1993-2020.

Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, et al. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1a. Cell 2005; 122: 505-515.

DOI: https://doi.org/10.1016/j.cell.2005.06.040

Weinlich G, Doss MO, Sepp N, Fritsch P. Variegate porphyria with coexistent decrease in porphobilinogen deaminase activity. Acta Derm Venereol 2001; 81: 356-359.

DOI: https://doi.org/10.1080/000155501317140098

Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, et al. Phase 3 trial of RNAi therapeutic givosiran for acute intermittent porphyria. NEJM 2020; 382: 2289-2301.

DOI: https://doi.org/10.1056/NEJMoa1913147

Wang B, Rudnick S, Cengia B, Bonkovsky HL. Acute hepatic porphyrias: review and recent progress. Hepatol Commun 2018; 3: 193-206.

DOI: https://doi.org/10.1002/hep4.1297

Di Pierro E, Granata F. Nutrients and porphyria: an intriguing crosstalk. Int J Mol Sci 2020; 21: 3462.

DOI: https://doi.org/10.3390/ijms21103462

Lane PR, Massey KL, Worobetz LJ, Jutras MN, Hull PR. Acute hereditary coproporphyria induced by the androgenic/anabolic steroid methandrostenolone (Dianabol). J Am Acad Dermatol 1994; 30: 308-312.

DOI: https://doi.org/10.1016/S0190-9622(94)70029-X

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Published

2021-03-11

How to Cite

Cussigh, C. S., Trenkler, N., Hoffmann, J. H., Enk, A. H., & Lonsdorf, A. S. (2021). Acute Variegate Porphyria in a Professional Bodybuilder after Starting a High-protein Diet and Treatment with Testosterone. Acta Dermato-Venereologica, 101(3), adv00412. https://doi.org/10.2340/00015555-3769

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