Exploring Capsaicin and Cinnamaldehyde for Scratching Behaviour in Mice: Effects of Sex, Concentration and Time Course

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DOI:

https://doi.org/10.2340/actadv.v103.9642

Keywords:

pruritus, capsaicin, cinnamaldehyde, scratching model, itch, TRPV, TRPA

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Author Biography

Alcir Luiz Dafre, Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianopolis, SC, Brazil.

Biologist at Federal University of Santa Catarina (1985), master (1989) and Ph.D. (1996) in Physiology at Universidade Federal do Rio Grande do Sul. Post-doc experiences at Johann Wolfgang Goethe Universitaet (2000), Otago University (2008), Salk Institute (2013 and 2015) and Universidade de São Paulo (2018). Working at Universidade Federal de Santa Catarina (1991), recognized as Professor Titular (2017), working as the head of Departament of Physiology (2003), and Department of Biochemistry (2016-2021), and as the Biology course coordinator or vice-coordinator (2007-2012). Dafre leads the Cell Defenses Lab. (Labdef), with emphasis in comparative physiology and neurosciences. In comparative physiology Dafre focused on cell defense mechanisms against toxicants, especially in fish and bivalves as models. Alzheimer-, Parkinson- and metal toxicology-related topics have been studied in vivo and in cell culture models. Recently has dedicated efforts in elucidating the molecular mechanisms related to methylglyoxal toxicity, an endogenous toxin. Key words related to research areas: glutathione metabolism, antioxidant defenses, oxidative stress, neuroprotection; redox regulation, glyoxalase, thioredoxin and peroxiredoxin. 

http://lattes.cnpq.br/7729955482153416

References

Han L, Dong X. Itch mechanisms and circuits. Annu Rev Biophys 2014; 43: 331-355.

https://doi.org/10.1146/annurev-biophys-051013-022826 DOI: https://doi.org/10.1146/annurev-biophys-051013-022826

Koch SC, Acton D, Goulding M. Spinal circuits for touch, pain, and itch. Annu Rev Physiol 2018; 80: 3-29.

https://doi.org/10.1146/annurev-physiol-022516-034303 DOI: https://doi.org/10.1146/annurev-physiol-022516-034303

Pluskal T, Weng JK. Natural product modulators of human sensations and mood: molecular mechanisms and therapeutic potential. Chem Soc Rev 2018; 47: 1592-1637.

https://doi.org/10.1039/C7CS00411G DOI: https://doi.org/10.1039/C7CS00411G

Atoyan R, Shander D, Botchkareva NV. Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol 2009; 129: 2312-2315.

https://doi.org/10.1038/jid.2009.58 DOI: https://doi.org/10.1038/jid.2009.58

Caterina MJ, Pang Z. TRP channels in skin biology and pathophysiology. Pharmaceuticals 2016; 9: 77.

https://doi.org/10.3390/ph9040077 DOI: https://doi.org/10.3390/ph9040077

Ohtsuka E, Kawai S, Ichikawa T, Nojima H, Kitagawa K, Shirai Y, et al. Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice. Jpn J Pharmacol 2001; 86: 97-105.

https://doi.org/10.1254/jjp.86.97 DOI: https://doi.org/10.1254/jjp.86.97

NIH (National Research Council (US)) - Guide for the Care and Use of Laboratory Animals Committee for the Update of the Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press (US); 2011.

Domocos D, Follansbee T, Nguyen A, Nguyen T, Carstens MI, Carstens E. Cinnamaldehyde elicits itch behavior via TRPV1 and TRPV4 but not TRPA1. Itch Phila Pa 2020; 5: e36.

https://doi.org/10.1097/itx.0000000000000036 DOI: https://doi.org/10.1097/itx.0000000000000036

Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D. Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature 2020; 585: 141-145.

https://doi.org/10.1038/s41586-020-2480-9 DOI: https://doi.org/10.1038/s41586-020-2480-9

Ma XL, Zhang FX, Dong F, Bao L, Zhang X. Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin. Mol Pain 2015; 11: 22.

https://doi.org/10.1186/s12990-015-0019-0 DOI: https://doi.org/10.1186/s12990-015-0019-0

Lolignier S, Bonnet C, Gaudioso C, Noël J, Ruel J, Amsalem M, et al. The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia. Cell Rep 2015; 11: 1067-1078.

https://doi.org/10.1016/j.celrep.2015.04.027 DOI: https://doi.org/10.1016/j.celrep.2015.04.027

Schut C, Zeidler C, Schneider G. Relevanz demographischer und psychologischer Faktoren bei Pruritus. Dermatol Heidelb Ger 2022; 73: 620-624.

https://doi.org/10.1007/s00105-022-05016-2 DOI: https://doi.org/10.1007/s00105-022-05016-2

Yamaura K, Tomono A, Suwa E, Ueno K. Sex-related differences in SLIGRL-induced pruritus in mice. Life Sci 2014; 94: 54-57.

https://doi.org/10.1016/j.lfs.2013.10.036 DOI: https://doi.org/10.1016/j.lfs.2013.10.036

Sikand P, Shimada SG, Green BG, LaMotte RH. Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain 2011; 152: 2485-2494.

https://doi.org/10.1016/j.pain.2011.06.001 DOI: https://doi.org/10.1016/j.pain.2011.06.001

Højland CR, Andersen HH, Poulsen JN, Arendt-Nielsen L, Gazerani P. A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde. Acta Derm Venereol 2015; 95: 798-803.

https://doi.org/10.2340/00015555-2103 DOI: https://doi.org/10.2340/00015555-2103

Published

2023-06-13

How to Cite

de Aquino, R. S., Torres, A. R., Dafre, A. L., & Santos, A. R. S. . (2023). Exploring Capsaicin and Cinnamaldehyde for Scratching Behaviour in Mice: Effects of Sex, Concentration and Time Course. Acta Dermato-Venereologica, 103, adv9642. https://doi.org/10.2340/actadv.v103.9642