Evaluation of therapeutic effects of nanofibrous mat containing mycophenolate mofetil on oral lichen planus: In vitro and clinical trial study

Authors

  • Mahdieh Alipour Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran;  Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Ehsan Habibivand Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Shayesteh Sekhavati Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Zahra Aghazadeh  Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;  Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammadreza Ranjkesh Department of Dermatology, School of Medicine, Sina Medical Research & Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
  • Soghra Ramezani Nanofiber Research Center, Asian Nanostructures Technology Co. (ANSTCO), Zanjan, Iran
  • Marziyeh Aghazadeh Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;  Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran;  Department of Bioscience Research, Department of Medicine – Cardiology, Department of Microbiology, Immunology & Biochemistry, University of Tennessee, Tennessee, USA
  • Marjan Ghorbani Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

DOI:

https://doi.org/10.1080/26415275.2023.2283177

Keywords:

Aloe-vera, Nanofibrous mat, Oral Lichen Planus, Mycophenolate, Zinc oxide nanoparticles

Abstract

Objectives

Recently, topical drug delivery system has gained increasing interest in the treatment of oral lesions. Lichen planus is a chronic inflammatory disease affecting mucous membranes and skin. The current study aimed to fabricate a drug delivery system containing mycophenolate mofetil for the treatment of oral lichen planus lesions.

Methods

Firstly, a nanofibrous mat containing mycophenolate mofetil, zinc oxide nanoparticles, and aloe vera was designed and fabricated. The antimicrobial, cytocompatibility, anti-inflammatory, and antioxidative characteristics of fabricated scaffolds were evaluated. Then, this nanofibrous mat was applied to 12 patients suffering from bilateral erythematous/erosive Oral Lichen planus (OLP) lesions for 2 weeks. The treatment outcomes, including oral symptoms and lesion size, were compared with the routine topical treatment of these lesions; Triamcinolone ointment.

Results

The characterization of nanofibrous mat approved the successful fabrication of scaffolds. The fabricated nanofibers showed notable antimicrobial activity. The amounts of TNF

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Published

2023-12-31

How to Cite

Alipour, M., Habibivand, E., Sekhavati, S., Aghazadeh, Z., Ranjkesh, M., Ramezani, S., … Ghorbani, M. (2023). Evaluation of therapeutic effects of nanofibrous mat containing mycophenolate mofetil on oral lichen planus: In vitro and clinical trial study. Biomaterial Investigations in Dentistry, 10(1). https://doi.org/10.1080/26415275.2023.2283177

Issue

Vol. 10 No. 1 (2023): Biomaterial Investigations in Dentistry

Section

Articles

License

Copyright (c) 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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