Therapeutic applications of red marine seaweeds in dental care: innovations in oral health and treatment

Authors

  • Sivakamavalli Jeyachandran Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.2340/biid.v12.45224

Keywords:

Red marine seaweeds, dental care, therapeutic applications, carrageenan, oral health, antimicrobial properties

Abstract

Red marine seaweeds, particularly those belonging to the genus Rhodophyta, possess a robust structural framework and are rich in biologically active compounds such as carrageenan, agar, collagen, and alginate. These natural resources are abundant and have attracted significant attention for their therapeutic potential in oral healthcare. This review highlights the applications of red marine seaweeds in dentistry, focusing on their roles in maintaining oral health, facilitating wound healing, exhibiting antibacterial properties, and contributing to tooth remineralization. Notably, their anti-inflammatory activity supports the management of conditions such as gingivitis, periodontitis, and oral ulcerations, while their antibacterial and antifungal actions effectively inhibit oral pathogens such as Streptococcus mutans, a primary contributor to dental caries. Furthermore, carrageenan-based biodegradable films derived from red seaweeds demonstrate promising potential as controlled drug delivery systems and tissue-regenerative biomaterials within the oral cavity. Beyond clinical applications, seaweeds can also serve as sustainable sources for formulating naturally derived oral hygiene products – including mouthwashes, toothpastes, and gels – offering eco-friendly alternatives to synthetic chemicals. However, despite these advances, broader clinical adoption requires comprehensive and well-designed clinical trials to validate efficacy and safety. Overall, this review underscores the emerging potential of red marine seaweeds as sustainable, bioactive resources for innovative dental therapeutics, while emphasizing the need for continued translational and clinical research.

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References

Ahmad, K., Khan, S., Afridi, M., Shah, M. A., Bilal, M., & Iqbal, H. M. N. (2022). Marine macroalgae polysaccharides-based nanomaterials: An overview with respect to nanoscience applications. Beni-Suef University Journal of Basic and Applied Sciences, 11, 156. https://doi.org/10.1186/s43088-022-00335-8 DOI: https://doi.org/10.1186/s43088-022-00335-8

Akshayaa, L., & Ganesh, B. S. (2025). Preparation of a carrageenan and fucoidan silica nanoparticle-based membrane for guided bone regeneration in dental implant sites. Journal of Long-Term Effects of Medical Implants, 35(2), 25–32. https://doi.org/10.1615/JLongTermEffMedImplants.2024049789 DOI: https://doi.org/10.1615/JLongTermEffMedImplants.2024049789

Alfinaikh, R. S., Alamry, K. A., & Hussein, M. A. (2025). Sustainable and biocompatible hybrid materials‑based sulfated polysaccharides for biomedical applications: A review. RSC Advances, 15(6), 4708–4767. https://doi.org/10.1039/D4RA07277D DOI: https://doi.org/10.1039/D4RA07277D

Alli, B. Y., Upadhyay, A., Zhang, Y., Nicolau, B., & Tran, S. D. (2022). In vitro toxicity evaluation of carrageenan on cells and tissues of the oral cavity. Marine Drugs, 20(8), 502. https://doi.org/10.3390/md20080502 DOI: https://doi.org/10.3390/md20080502

Ayala, M., Goosen, N., Michalak, L., Thomsen, M., & Pizzol, M. (2024). Prospective LCA of brown seaweed-based bioplastic: Upscaling from pilot to industrial scale. Sustainable Production and Consumption, 52, 416–426. https://doi.org/10.1016/j.spc.2024.11.020 DOI: https://doi.org/10.1016/j.spc.2024.11.020

Bajpai, D., & Kaarthikeyan, G. (2024). Development and evaluation of alginate- and carrageenan-incorporated scaffold for bone regeneration: An in vitro study. Cureus, 16(5), e61139. https://doi.org/10.7759/cureus.61139 DOI: https://doi.org/10.7759/cureus.61139

Balasubramaniam, A., Arumugham, M. A., Nathan, S. N. P., Santhosh Kumar, M. P., Murugesan, K., Dharmaraj, S., Thangavelu, L., Yadalam, P. K., Ramadoss, R., & Ashokkumar, V. (2022). Emerging technologies and potential applications of algae in dentistry – A critical review. Journal of Biotechnology, 360, 1–10. https://doi.org/10.1016/j.jbiotec.2022.09.021 DOI: https://doi.org/10.1016/j.jbiotec.2022.09.021

Buschmann, A., & Sudhakar, M. P. (2024). Applications of seaweed biopolymers and its composites in dental applications. Journal of Applied Biology & Biotechnology, 12(1), 62–68. https://doi.org/10.7324/JABB.2024.143201

Cao, W., Jin, J., Wu, G., Bravenboer, N., Helder, M. N., Pathak, J. L., Zandieh-Doulabi, B., Hogervorst, J. M. A., Matsukawa, S., Geonzon, L. C., Bacabac, R. G., Schulten, E. A. J. M., & Klein-Nulend, J. (2021). K-Carrageenan stimulates pre-osteoblast proliferation and osteogenic differentiation: A potential factor for the promotion of bone regeneration? Molecules, 26(20), 6131. https://doi.org/10.3390/molecules26206131 DOI: https://doi.org/10.3390/molecules26206131

Cao, W., Jin, J., Wu, G., Bravenboer, N., Helder, M. N., Schulten, E. A. J. M., Bacabac, R. G., Pathak, J. L., & Klein-Nulend, J. (2022). Kappacarrageenan-functionalization of octacalcium phosphate-coated titanium discs enhances pre-osteoblast behavior and osteogenic differentiation. Frontiers in Bioengineering and Biotechnology, 10, 1011853. https://doi.org/10.3389/fbioe.2022.1011853 DOI: https://doi.org/10.3389/fbioe.2022.1011853

Carpena, M., Garcia-Perez, P., Garcia-Oliveira, P., Chamorro, F., Otero, P., Lourenço-Lopes, C., ... & Prieto, M. A. (2023). Biological properties and potential of compounds extracted from red seaweeds. Phytochemistry Reviews, 22(6), 1509–1540. https://doi.org/10.1007/s11101-022-09826-z DOI: https://doi.org/10.1007/s11101-022-09826-z

Carrilho, R., & Bretz, W. (2023). Red marine algae lithothamnion calcareum supports dental enamel mineralization. Marine Drugs, 21(2), 109. https://doi.org/10.3390/md21020109 DOI: https://doi.org/10.3390/md21020109

Chudasama, N. A., Sequeira, R. A., Moradiya, K., & Prasad, K. (2021). Seaweed polysaccharide-based products and materials: An assessment on their production from a sustainability point of view. Molecules, 26(9), 2608. https://doi.org/10.3390/molecules26092608 DOI: https://doi.org/10.3390/molecules26092608

Das, I. J., & Bal, T. (2024). Exploring carrageenan: From seaweed to biomedicine – A comprehensive review. International Journal of Biological Macromolecules, 268(Pt 2), 131822. https://doi.org/10.1016/j.ijbiomac.​2024.131822 DOI: https://doi.org/10.1016/j.ijbiomac.2024.131822

Devi, G. V. Y., Nagendra, A. H., Shenoy, P. S., Chatterjee, K., & Venkatesan, J. (2022). Fucoidan-incorporated composite scaffold stimulates osteogenic differentiation of mesenchymal stem cells for bone tissue engineering. Marine Drugs, 20(10), 589. https://doi.org/10.3390/md20100589 DOI: https://doi.org/10.3390/md20100589

Dou, X., Li, G., Wang, S., Shao, D., Wang, D., Deng, X., Zhu, Y., Gao, P., Liu, J., Deng, N., Yuan, C., & Zhou, Q. (2023). Probiotic-loaded calcium alginate/fucoidan hydrogels for promoting oral ulcer healing. International Journal of Biological Macromolecules, 244, 125273. https://doi.org/10.1016/j.ijbiomac.2023.125273 DOI: https://doi.org/10.1016/j.ijbiomac.2023.125273

Eshwar, S., Konuganti, K., Manvi, S., Bharadwaj, A. N., Sajjan, S., Boregowda, S. S., & Jain, V. (2023). Evaluation of osteogenic potential of fucoidan containing chitosan hydrogel in the treatment of periodontal intra-bony defects—a randomized clinical trial. Gels, 9(7), 573. https://doi.org/10.3390/gels9070573 DOI: https://doi.org/10.3390/gels9070573

González Ocampo, J. I., Machado de Paula, M. M., Bassous, N. J., Lobo, A. O., Ossa Orozco, C. P., & Webster, T. J. (2019). Osteoblast responses to injectable bone substitutes of kappa-carrageenan and nano hydroxyapatite. Acta Biomaterialia, 83, 425–434. https://doi.org/10.1016/j.actbio.2018.10.023 DOI: https://doi.org/10.1016/j.actbio.2018.10.023

González-Gloria, K. D., Rodríguez-Jasso, R. M., Shiva, E., Aparicio, E., Chávez-González, M. L., Kostas, E. T., & Ruiz, H. A. (2021). Macroalgal biomass in terms of third-generation biorefinery concept: Current status and techno-economic analysis – A review. Bioresource Technology Reports, 16, 100863. https://doi.org/10.1016/j.biteb.2021.100863 DOI: https://doi.org/10.1016/j.biteb.2021.100863

He, Y., Cao, Y., Xiang, Y., Hu, F., Tang, F., Zhang, Y., Albashari, A. A., Xing, Z., Luo, L., Sun, Y., Huang, Q., Ye, Q., & Zhang, K. (2020). An evaluation of norspermidine on anti‑fungal effect on mature Candida albicans biofilms and angiogenesis potential of dental pulp stem cells. Frontiers in Bioengineering and Biotechnology, 8, 948. https://doi.org/10.3389/fbioe.2020.00948 DOI: https://doi.org/10.3389/fbioe.2020.00948

Huang, S.-M., Liu, S.-M., Ko, C.-L., & Chen, W.-C. (2022). Advances of hydroxyapatite hybrid organic composite used as drug or protein carriers for biomedical applications: A review. Polymers, 14(5), 976. https://doi.org/10.3390/polym14050976 DOI: https://doi.org/10.3390/polym14050976

Jeong, J. W., Park, D. J., Kim, S. C., Kang, H. W., Lee, B., Kim, H. W., ... & Jung, W. K. (2025). Wound healing effect of fucoidan-loaded gelatin/oxidized carboxymethyl cellulose hydrogel. International Journal of Biological Macromolecules, 286, 138254. https://doi.org/10.1016/j.ijbiomac.2024.138254 DOI: https://doi.org/10.1016/j.ijbiomac.2024.138254

Jin, Y., Yu, Q., Li, S., Chen, T., & Liu, D. (2023). Application of seaweed polysaccharide in bone tissue regeneration. Frontiers in Marine Science, 10, 1202422. https://doi.org/10.3389/fmars.2023.1202422. DOI: https://doi.org/10.3389/fmars.2023.1202422

Jumaidin, R., Sapuan, S. M., Jawaid, M., Ishak, M. R., & Sahari, J. (2018). Seaweeds as renewable sources for biopolymers and its composites: A review. Current Analytical Chemistry, 14(3), 249–267. https://doi.org/​10.2174/1573411013666171009164355 DOI: https://doi.org/10.2174/1573411013666171009164355

Jung, S. M., Lee, J. H., Han, S. H., Hwang, Y. J., & Kang, C. K. (2020). A new approach to the restoration of seaweed beds using Sargassum fulvellum. Journal of Applied Phycology, 32, 2575–2581. https://doi.org/10.1007/s10811-020-02054-y DOI: https://doi.org/10.1007/s10811-020-02054-y

Kajla, P., Chaudhary, V., Dewan, A., Bangar, S. P., Ramniwas, S., Rustagi, S., & Pandiselvam, R. (2024). Seaweed-based biopolymers for food packaging: A sustainable approach for a cleaner tomorrow. International Journal of Biological Macromolecules, 274(Part 1), 133166. https://doi.org/10.1016/j.ijbiomac.2024.133166. DOI: https://doi.org/10.1016/j.ijbiomac.2024.133166

Kikionis, S., Iliou, K., Karra, A. G., Polychronis, G., Choinopoulos, I., Iatrou, H., ... & Roussis, V. (2023). Development of bi-and tri-Layer nanofibrous membranes based on the sulfated polysaccharide carrageenan for periodontal tissue regeneration. Marine Drugs, 21(11), 565. https://doi.org/10.3390/md21110565. DOI: https://doi.org/10.3390/md21110565

Krishnan, L., Ravi, N., Mondal, A. K., Akter, F., Kumar, M., Ralph, P., & Kuzhiumparambil, U. N. (2024). Seaweed-based polysaccharides – Review of extraction, characterization, and bioplastic application. Green Chemistry, 26, 5790–5823. https://doi.org/10.1039/D3GC04009G DOI: https://doi.org/10.1039/D3GC04009G

Liyanage, N. M., Nagahawatta, D. P., Jayawardena, T. U., Sanjeewa, K. K. A., Jayawardhana, H. H. A. C. K., Kim, J.-I., & Jeon, Y.-J. (2023). Sulfated polysaccharides from seaweeds: A promising strategy for combatting viral diseases – A review. Marine Drugs, 21(9), 461. https://doi.org/10.3390/md21090461 DOI: https://doi.org/10.3390/md21090461

Martin, N., & Mulligan, S. (2022). Environmental sustainability through good-quality oral healthcare. International Dental Journal, 72(1), 26–30. https://doi.org/10.1016/j.identj.2021.06.005 DOI: https://doi.org/10.1016/j.identj.2021.06.005

Marunganathan, V., Kumar, M. S. K., Kari, Z. A., Al-Ezzi, A., Abdul Razak, S., Al-Kahtani, H. A., & Algahtani, F. D. (2024). Marine-derived κ-carrageenan-coated zinc oxide nanoparticles for targeted drug delivery and apoptosis induction in oral cancer. Molecular Biology Reports, 51(1), 89. https://doi.org/10.1007/s11033-023-09146-1 DOI: https://doi.org/10.1007/s11033-023-09146-1

Mirza, S., Jolly, R., Zia, I., Saad Umar, M., Owais, M., & Shakir, M. (2020). Bioactive gum Arabic/κ-Carrageenan-incorporated nano-hydroxyapatite nanocomposites and their relative biological functionalities in bone tissue engineering. ACS Omega, 5(20), 11279–11290. https://doi.org/10.1021/acsomega.9b03761 DOI: https://doi.org/10.1021/acsomega.9b03761

Mittal, R., Maheshwari, R., Tripathi, S., & Pandey, S. (2020). Eco-friendly dentistry: Preventing pollution to promoting sustainability. Indian Journal of Dental Sciences, 12(4), 251–257. https://doi.org/10.4103/IJDS.IJDS_12_20 DOI: https://doi.org/10.4103/IJDS.IJDS_12_20

Nor, A. M., Gray, T. S., Caldwell, G. S., Lananan, F., & Chisti, Y. (2020). A value chain analysis of Malaysia’s seaweed industry. Journal of Applied Phycology, 32, 2161–2171. https://doi.org/10.1007/s10811-019-02004-3 DOI: https://doi.org/10.1007/s10811-019-02004-3

Putri, D. A. L., Ridlo, A., & Hartati, R. (2025). The characteristics of bioplastic made from sodium alginate and kappa carrageenan. Jurnal Kelautan Tropis, 28(1), 97–106. https://doi.org/10.14710/jkt.v28i1.25887 DOI: https://doi.org/10.14710/jkt.v28i1.25887

Rambe, A. O., Eriwati, Y. K., & Santosa, A. S. (2018). Preparation of experimental dental alginate impression material from Sargassum spp. seaweed extract based on its setting time. Journal of Physics: Conference Series, 1073(5), 052013. https://doi.org/10.1088/1742-6596/​1073/5/052013 DOI: https://doi.org/10.1088/1742-6596/1073/5/052013

Shim, N. Y., Ryu, J. I., & Heo, J. S. (2022). Osteoinductive function of fucoidan on periodontal ligament stem cells: Role of PI3K/Akt and Wnt/β-catenin signaling pathways. Oral Diseases, 28(6), 1628–1639. https://doi.org/10.1111/odi.13829 DOI: https://doi.org/10.1111/odi.13829

Sudhakar, M. P., Nallasamy, V. D., Dharani, G., & Buschmann, A. H. (2023). Applications of seaweed biopolymers and its composites in dental applications. Journal of Applied Biology & Biotechnology, 12(1), 62–68. https://doi.org/10.7324/JABB.2024.143201 DOI: https://doi.org/10.7324/JABB.2024.143201

Sun, X., Ai, C., Wen, C., Peng, H., Yang, J., Cui, Y., & Song, S. (2022). Inhibitory effects of fucoidan from Laminaria japonica against some pathogenic bacteria and SARS‑CoV‑2 depend on its large molecular weight. International Journal of Biological Macromolecules, 229, 413–421. https://doi.org/10.1016/j.ijbiomac.2022.12.307 DOI: https://doi.org/10.1016/j.ijbiomac.2022.12.307

Tabassum, N., Khan, F., Kang, M. G., Jo, D. M., Cho, K. J., & Kim, Y. M. (2023). Inhibition of polymicrobial biofilms of Candida albicans–Staphylococcus aureus/Streptococcus mutans by fucoidan-gold nanoparticles. Marine Drugs, 21(2), 123. https://doi.org/10.3390/md21020123 DOI: https://doi.org/10.3390/md21020123

Thitame, S. N., Aher, A. A., & Mopagar, V. (2025). Exploring the role of algae in promoting oral health: Antimicrobial, anti-inflammatory, and tissue healing benefits. Journal of Pharmacy and Bioallied Sciences, 17(Suppl 1), S9–S11. https://doi.org/10.4103/jpbs.jpbs_1761_24 DOI: https://doi.org/10.4103/jpbs.jpbs_1761_24

Waghmare, G., Waghmare, K., Bagde, S., Deshmukh, M., Kashyap, D. N., & Shahu, V. T. (2024). Materials evolution in dental implantology: A comprehensive review. Journal of Advanced Research in Applied Mechanics, 123(1), 75–100. DOI: https://doi.org/10.37934/aram.123.1.75100

Wen, W., Yang, L., Wang, X., Zhang, H., Wu, F., Xu, K., Chen, S., & Liao, Z. (2023). Fucoidan promotes angiogenesis and accelerates wound healing through AKT/Nrf2/HIF-1α signalling pathway. International Wound Journal, 20(9), 3606–3618. https://doi.org/10.1111/iwj.14239 DOI: https://doi.org/10.1111/iwj.14239

Xie, Y., Wang, Z., Liu, L., Fan, C., Wang, J., Yang, J., Hao, Y., Mei, L., Su, W., & Xu, Q. (2024). Fucoidan-hybrid hydroxyapatite nanoparticles promote the osteogenic differentiation of human periodontal ligament stem cells under inflammatory condition. International Journal of Biological Macromolecules, 270, 132416. https://doi.org/10.1016/j.ijbiomac.2024.132416 DOI: https://doi.org/10.1016/j.ijbiomac.2024.132416

Zhang, Y., Gulati, K., Li, Z., Di, P., & Liu, Y. (2021). Dental implant nano-engineering: Advances, limitations and future directions. Nanomaterials, 11(10), 2489. https://doi.org/10.3390/nano11102489 DOI: https://doi.org/10.3390/nano11102489

Zhao, Y., Wu, J., Kang, X., Guo, Y., Wang, L., Sheng, X., & Tan, Z. (2024). Elemental profiling of red seaweed Neopyropia yezoensis used in fast authenticating the geographical origin and food safety assessment. Journal of Food Composition and Analysis, 125, 105839. https://doi.org/10.1016/j.jfca.2023.105839 DOI: https://doi.org/10.1016/j.jfca.2023.105839

Published

2025-12-29

How to Cite

Jeyachandran, S. (2025). Therapeutic applications of red marine seaweeds in dental care: innovations in oral health and treatment. Biomaterial Investigations in Dentistry, 12(1), 300–312. https://doi.org/10.2340/biid.v12.45224