Preoperative physiotherapy and one-year patient-reported outcomes after primary total knee arthroplasty: a registry-based cohort study of 1,688 patients
DOI:
https://doi.org/10.2340/jrm.v58.44853Keywords:
preoperative physiotherapy, total knee arthroplasty, physical function, prehabilitationAbstract
Objective: Preoperative physiotherapy in patients receiving primary total knee arthroplasty (TKA) aims to relieve pain, delay surgery, and improve postoperative recovery. This study investigates the change in PROMs and pain after primary TKA between patients who received preoperative physiotherapy (P) and those who did not (NP).
Design: Registry-based cohort study with data from an institutional registry.
Patients: 1,688 patients followed a standardized fast-track clinical pathway between August 2017 and January 2024 and were grouped in P or NP.
Methods: Primary outcome was KOOS-PS at 2 months and 1 year postoperatively. Secondary outcomes included pain, the Forgotten Joint Score, and EQ-5d-5L. Two anchor questions related to self-perceived knee function and willingness to have the surgery again at 12 months’ follow-up were also evaluated.
Results: The model estimate demonstrated no significant between-group difference in KOOS-PS at 2 months (1.12 points; p = 0.079) or 1-year follow-up (1.25 points; p = 0.097). Visual inspection of descriptive plots showed that NP patients had higher KOOS-PS, less pain, and better joint score and quality of life at all time points. At 12 months’ follow-up, both groups had similar responses to the anchor questions.
Conclusion: After adjustment for baseline differences, no between-group differences in postoperative self-reported physical function were observed; consistently lower scores in the physiotherapy group may reflect systematic preoperative differences between groups.
Downloads
References
Kang Y, Liu C, Ji Y, Zhang H, Wang Y, Bi W, et al. The burden of knee osteoarthritis worldwide, regionally, and nationally from 1990 to 2019, along with an analysis of cross-national inequalities. Arch Orthop Trauma Surg 2024; 144: 2731–2743. DOI: https://doi.org/10.1007/s00402-024-05250-4
Hiligsmann M, Cooper C, Arden N, Boers M, Branco JC, Luisa Brandi M, et al. Health economics in the field of osteoarthritis: an expert’s consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum 2013; 43: 303–313. DOI: https://doi.org/10.1016/j.semarthrit.2013.07.003
Gao J, Xing D, Dong S, Lin J. The primary total knee arthroplasty: a global analysis. J Orthop Surg Res 2020; 15: 190. DOI: https://doi.org/10.1186/s13018-020-01707-5
Oka T, Ono R, Tsuboi Y, Wada O, Kaga T, Tamura Y, et al. Effect of preoperative sedentary behavior on clinical recovery after total knee arthroplasty: a prospective cohort study. Clin Rheumatol 2020; 39: 891–898. DOI: https://doi.org/10.1007/s10067-019-04849-y
Barber-Westin S, Noyes FR. Effect of preoperative rehabilitation on clinical outcomes and function after knee arthroplasty. In: F Noyes R, Barber-Westin S, wditors. Critical rehabilitation for partial and total knee arthroplasty: guidelines and objective testing to allow return to physical function, recreational and sports activities. Cham: Springer International Publishing; 2022. p. 79–92. DOI: https://doi.org/10.1007/978-3-030-87003-4_5
Gillis C, Ljungqvist O, Carli F. Prehabilitation, enhanced recovery after surgery, or both? A narrative review. Br J Anaesth 2022; 128: 434–448. DOI: https://doi.org/10.1016/j.bja.2021.12.007
McIsaac DI, Kidd G, Gillis C, Branje K, Al-Bayati M, Baxi A, et al. Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials. BMJ 2025; 388: e081164. DOI: https://doi.org/10.1136/bmj-2024-081164
Chen H, Li S, Ruan T, Liu L, Fang L. Is it necessary to perform prehabilitation exercise for patients undergoing total knee arthroplasty: meta-analysis of randomized controlled trials. Phys Sportsmed 2018; 46: 36–43. DOI: https://doi.org/10.1080/00913847.2018.1403274
Su W, Zhou Y, Qiu H, Wu H. The effects of preoperative rehabilitation on pain and functional outcome after total knee arthroplasty: a meta-analysis of randomized controlled trials. J Orthop Surg Res 2022; 17: 175. DOI: https://doi.org/10.1186/s13018-022-03066-9
Calatayud J, Casaña J, Ezzatvar Y, Jakobsen MD, Sundstrup E, Andersen LL. High-intensity preoperative training improves physical and functional recovery in the early post-operative periods after total knee arthroplasty: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc 2017; 25: 2864–2872. DOI: https://doi.org/10.1007/s00167-016-3985-5
Konnyu KJ, Thoma LM, Cao W, Aaron RK, Panagiotou OA, Bhuma MR, et al. Prehabilitation for total knee or total hip arthroplasty: a systematic review. Am J Phys Med Rehabil 2023; 102: 1–10. DOI: https://doi.org/10.1097/PHM.0000000000002006
Hayashi K, Janowski A, Lesnak JB, Sluka KA. Preoperative exercise has a modest effect on postoperative pain, function, quality of life, and complications: a systematic review and meta-analysis. Phys Ther 2023; 103. DOI: https://doi.org/10.1093/ptj/pzac169
Vasileiadis D, Drosos G, Charitoudis G, Dontas I, Vlamis J. Does preoperative physiotherapy improve outcomes in patients undergoing total knee arthroplasty? A systematic review. Musculoskeletal Care 2022; 20: 487–502. DOI: https://doi.org/10.1002/msc.1616
Punnoose A, Claydon-Mueller LS, Weiss O, Zhang J, Rushton A, Khanduja V. Prehabilitation for patients undergoing orthopedic surgery: a systematic review and meta-analysis. JAMA Netw Open 2023; 6: e238050. DOI: https://doi.org/10.1001/jamanetworkopen.2023.8050
Wang D, Wu T, Li Y, Jia L, Ren J, Yang L. A systematic review and meta-analysis of the effect of preoperative exercise intervention on rehabilitation after total knee arthroplasty. Ann Palliat Med 2021; 10: 10986–10996. DOI: https://doi.org/10.21037/apm-21-2670
Sun JN, Shan YZ, Wu LX, Li N, Xu FH, Kong XR, et al. Preoperative high-intensity strength training combined with balance training can improve early outcomes after total knee arthroplasty. J Orthop Surg Res 2023; 18: 692. DOI: https://doi.org/10.1186/s13018-023-04197-3
Jørgensen SL, Kierkegaard S, Bohn MB, Aagaard P, Mechlenburg I. Effects of resistance training prior to total hip or knee replacement on post-operative recovery in functional performance: a systematic review and meta-analysis. Front Sports Act Living 2022; 4: 924307. DOI: https://doi.org/10.3389/fspor.2022.924307
Izadi M, Tøien T, Øhrn FD, Schnell Husby O, Kvitland Schnell Husby V, Bjørgen Winther S, et al. Effects of preoperative maximal strength training on muscle strength and function in total knee arthroplasty: a randomized controlled trial. Ann Phys Rehabil Med 2026; 69: 102067. DOI: https://doi.org/10.1016/j.rehab.2025.102067
Huber EO, Roos EM, Meichtry A, de Bie RA, Bischoff-Ferrari HA. Effect of preoperative neuromuscular training (NEMEX-TJR) on functional outcome after total knee replacement: an assessor-blinded randomized controlled trial. BMC Musculoskelet Disord 2015; 16: 101. DOI: https://doi.org/10.1186/s12891-015-0556-8
Jordan RW, Smith NA, Chahal GS, Casson C, Reed MR, Sprowson AP. Enhanced education and physiotherapy before knee replacement; is it worth it? A systematic review. Physiotherapy 2014; 100: 305–312. DOI: https://doi.org/10.1016/j.physio.2014.03.003
Cabilan CJ, Hines S, Munday J. The effectiveness of prehabilitation or preoperative exercise for surgical patients: a systematic review. JBI Database System Rev Implement Rep 2015; 13: 146–187. DOI: https://doi.org/10.11124/jbisrir-2015-1885
Cavill S, McKenzie K, Munro A, McKeever J, Whelan L, Biggs L, et al. The effect of prehabilitation on the range of motion and functional outcomes in patients following the total knee or hip arthroplasty: a pilot randomized trial. Physiother Theory Pract 2016; 32: 262–270. DOI: https://doi.org/10.3109/09593985.2016.1138174
Kwok IHY, Paton B, Haddad FS. Does pre-operative physiotherapy improve outcomes in primary total knee arthroplasty? A systematic review. J Arthroplasty 2015; 30: 1657–1663. DOI: https://doi.org/10.1016/j.arth.2015.04.013
Adebero T, Omana H, Somerville L, Lanting B, Hunter SW. Effectiveness of prehabilitation on outcomes following total knee and hip arthroplasty for osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Disabil Rehabil 2024: 1–20. DOI: https://doi.org/10.1080/09638288.2024.2313128
Silverman SL. From randomized controlled trials to observational studies. Am J Med 2009; 122: 114–120. DOI: https://doi.org/10.1016/j.amjmed.2008.09.030
Sheldrick RC. Randomized trials vs real-world evidence: how can both inform decision-making? JAMA 2023; 329: 1352–1353. DOI: https://doi.org/10.1001/jama.2023.4855
Rombey T, Eckhardt H, Kiselev J, Silzle J, Mathes T, Quentin W. Cost-effectiveness of prehabilitation prior to elective surgery: a systematic review of economic evaluations. BMC Med 2023; 21: 265. DOI: https://doi.org/10.1186/s12916-023-02977-6
Winther SB, Foss OA, Wik TS, Davis SP, Engdal M, Jessen V, et al. 1-year follow-up of 920 hip and knee arthroplasty patients after implementing fast-track. Acta Orthop 2015; 86: 78–85. DOI: https://doi.org/10.3109/17453674.2014.957089
Kehlet H. Fast-track hip and knee arthroplasty. Lancet 2013; 381: 1600–1602. DOI: https://doi.org/10.1016/S0140-6736(13)61003-X
Peter WF, Tilbury C, Verdegaal SHM, Onstenk R, Vehmeijer SB, Vermeulen EM, et al. The provision of preoperative and postoperative physical therapy in elderly people with hip and knee osteoarthritis undergoing primary joint replacement surgery. Curr Orthop Pract 2016; 27: 173–183. DOI: https://doi.org/10.1097/BCO.0000000000000347
Young JL, Rhon DI, Cleland JA, Snodgrass SJ. The influence of exercise dosing on outcomes in patients with knee disorders: a systematic review. J Orthop Sports Phys Ther 2018; 48: 146–161. DOI: https://doi.org/10.2519/jospt.2018.7637
Jamtvedt G, Dahm KT, Holm I, Flottorp S. Measuring physiotherapy performance in patients with osteoarthritis of the knee: a prospective study. BMC Health Serv Res 2008; 8: 145. DOI: https://doi.org/10.1186/1472-6963-8-145
Langenberger B, Schrednitzki D, Halder AM, Busse R, Pross CM. Predicting whether patients will achieve minimal clinically important differences following hip or knee arthroplasty. Bone Joint Res 2023; 12: 512–521. DOI: https://doi.org/10.1302/2046-3758.129.BJR-2023-0070.R2
Zhao Y, Tian C, Tian S, Han W, Shi H, Cao M, et al. An umbrella review for preoperative rehabilitation in primary total knee arthroplasty: quality assessment and summary of evidence. BMC Musculoskelet Disord 2025; 26: 630. DOI: https://doi.org/10.1186/s12891-025-08541-y
Wang L, Lee M, Zhang Z, Moodie J, Cheng D, Martin J. Does preoperative rehabilitation for patients planning to undergo joint replacement surgery improve outcomes? A systematic review and meta-analysis of randomised controlled trials. BMJ Open 2016; 6: e009857. DOI: https://doi.org/10.1136/bmjopen-2015-009857
Ackerman IN, Bennell KL. Does pre-operative physiotherapy improve outcomes from lower limb joint replacement surgery? A systematic review. Aust J Physiother 2004; 50: 25–30. DOI: https://doi.org/10.1016/S0004-9514(14)60245-2
Tubach F, Ravaud P, Martin-Mola E, Awada H, Bellamy N, Bombardier C, et al. Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: results from a prospective multinational study. Arthritis Care Res (Hoboken) 2012; 64: 1699–1707. DOI: https://doi.org/10.1002/acr.21747
Aytekin E, Sukur E, Oz N, Telatar A, Eroglu Demir S, Sayiner Caglar N, et al. The effect of a 12 week prehabilitation program on pain and function for patients undergoing total knee arthroplasty: a prospective controlled study. J Clin Orthop Trauma 2019; 10: 345–349. DOI: https://doi.org/10.1016/j.jcot.2018.04.006
Gränicher P, Mulder L, Lenssen T, Scherr J, Swanenburg J, de Bie R. Prehabilitation improves knee functioning before and within the first year after total knee arthroplasty: a systematic review with meta-analysis. J Orthop Sports Phys Ther 2022; 52: 709–725. DOI: https://doi.org/10.2519/jospt.2022.11160
Hammett T, Simonian A, Austin M, Butler R, Allen KD, Ledbetter L, et al. Changes in physical activity after total hip or knee arthroplasty: a systematic review and meta-analysis of six- and twelve-month outcomes. Arthritis Care Res (Hoboken) 2018; 70: 892–901. DOI: https://doi.org/10.1002/acr.23415
Downloads
Published
How to Cite
License
Copyright (c) 2026 Siri B. Winther, Mani Izadi, Vigdis K.S. Husby, Otto S. Husby, Mathias F. Brobakken, Frank-David Øhrn, Jomar Klaksvik, Eivind Wang, Ole Kristian Berg

This work is licensed under a Creative Commons Attribution 4.0 International License.
All digitalized JRM contents is available freely online. The Foundation for Rehabilitation Medicine owns the copyright for all material published until volume 40 (2008), as from volume 41 (2009) authors retain copyright to their work and as from volume 49 (2017) the journal has been published Open Access, under CC-BY-NC licences (unless otherwise specified). The CC-BY-NC licenses allow third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
From 2024, articles are published under the CC-BY licence. This license permits sharing, adapting, and using the material for any purpose, including commercial use, with the condition of providing full attribution to the original publication.