Systematic Review and Meta-analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia

Authors

  • Yueqi Qiu
  • Xingyu Zhou
  • Siqi Fu
  • Shuaihantian Luo
  • Yaping Li Second Xiangya Hospital, Central South University, #139 Renmin Middle Rd, Changsha, Hunan 410011, P.R. China

DOI:

https://doi.org/10.2340/actadv.v101.1012

Keywords:

alopecia, androgens, metabolic syndrome, systematic review, meta-analysis

Abstract

The association of androgenetic alopecia with metabolic syndrome has been investigated in several studies, with conflicting results. We conducted a meta-analysis to quantitatively evaluate the risk grade of metabolic syndrome and the metabolic profile in patients with androgenetic alopecia compared with controls. In total, 19 articles (2,531 participants) satisfied the inclusion criteria. The pooled odds ratio for the prevalence rate of metabolic syndrome between the group with androgenetic alopecia and controls was 3.46 (95% CI 2.38–5.05; p < 0.001). Female sex, early onset, and African ethnicity were associated with an increased risk of metabolic syndrome. Furthermore, patients with androgenetic alopecia had significantly poorer metabolic profiles, such as body mass index, waist circumference, fasting glucose, blood lipids, and blood pressure. It is important for physicians to screen metabolism-related indicators in patients with androgenetic alopecia. More rigorously designed studies and larger sample sizes are required in future studies.

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Published

2022-02-08

How to Cite

Qiu, Y., Zhou, X., Fu, S., Luo, S., & Li, Y. (2022). Systematic Review and Meta-analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia. Acta Dermato-Venereologica, 102, adv00645. https://doi.org/10.2340/actadv.v101.1012