Assessment of Sclerodermoid Chronic Graft-versus-host Disease with Colour Doppler Ultrasound
Keywords:graft-versus-host disease, Doppler ultrasound, diagnosis, sclerodermoid, inflammation, allogeneic haematopoietic stem cell transplantation
Sclerodermoid chronic graft-versus-host disease (scGVHD) is a severe complication of allogeneic haema- topoietic stem cell transplantation. The aim of this study was to investigate the usefulness of high-frequency ultrasound of the skin in assessing the inflammatory patterns and prognosis of patients with scGVHD. A prospective study was carried out with patients who developed scGVHD in the period June 2016 to April 2018. Clinical and ultrasound examinations were performed on the first visit and at 6-month follow-up. A total of 24 patients were included in the study. A 6-month follow-up high-frequency ultrasound of the skin was performed on 20 of the 24 patients. Abnormal B-mode findings in high-frequency ultrasound of the skin consisted of hypoechogenic dermis, hypoechogenicity of septa and hyperechogenicity of lobules in hypodermis. No differences were observed in these basal parameters between treatment progressive/non-responding and inactive/responding scGVHD groups of patients. Basal Doppler showing increased vascular flow with a systolic peak ≥10 cm/s and a vascular resistance index ≥ 0.70 was observed only in those patients who developed progressive/non-responding scGVHD (62.5% vs 0% p = 0.006). In conclusion, Doppler ultrasound is a useful tool to assess the inflammatory activity and outcome of scGVHD. These findings could enhance patient management and help to guide treatment decisions.
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Copyright (c) 2021 Priscila Giavedoni, Carmen Martinez, Sebastian Podlipnik, María Suárez-Lleidó, Ignasi Martí-Martí, Daniel Morgado-Carrasco, Montserrat Rovira, Fernández-Avilés Fernández-Avilés, Gonzalo Gutiérrez, Laura Rosiñol, Joan Cid, Miquel Lozano, José Manuel Mascaró Jr.
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