Assessment of Sclerodermoid Chronic Graft-versus-host Disease with Colour Doppler Ultrasound

Authors

  • Priscila Giavedoni Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Villarroel 170, ES-08036 Barcelona, Spain
  • Carmen Martinez
  • Sebastian Podlipnik
  • María Suárez-Lleidó
  • Ignasi Martí-Martí
  • Daniel Morgado-Carrasco
  • Montserrat Rovira
  • Fernández-Avilés Fernández-Avilés
  • Gonzalo Gutiérrez
  • Laura Rosiñol
  • Joan Cid
  • Miquel Lozano
  • José Manuel Mascaró Jr.

DOI:

https://doi.org/10.2340/00015555-3747

Keywords:

graft-versus-host disease, Doppler ultrasound, diagnosis, sclerodermoid, inflammation, allogeneic haematopoietic stem cell transplantation

Abstract

Sclerodermoid chronic graft-versus-host disease (scGVHD) is a severe complication of allogeneic haema­- topoietic stem cell transplantation. The aim of this study was to investigate the usefulness of high-frequency ultrasound of the skin in assessing the inflammatory patterns and prognosis of patients with scGVHD. A prospective study was carried out with patients who developed scGVHD in the period June 2016 to April 2018. Clinical and ultrasound examinations were performed on the first visit and at 6-month follow-up. A total of 24 patients were included in the study. A 6-month follow-up high-frequency ultrasound of the skin was performed on 20 of the 24 patients. Abnormal B-mode findings in high-frequency ultrasound of the skin consisted of hypoechogenic dermis, hypoechogenicity of septa and hyperechogenicity of lobules in hypodermis. No differences were observed in these basal parameters between treatment progressive/non-responding and inactive/responding scGVHD groups of patients. Basal Doppler showing increased vascular flow with a systolic peak ≥10 cm/s and a vascular resistance index ≥ 0.70 was observed only in those patients who developed progressive/non-responding scGVHD (62.5% vs 0% p = 0.006). In conclusion, Doppler ultrasound is a useful tool to assess the inflammatory activity and outcome of scGVHD. These findings could enhance patient management and help to guide treatment decisions.

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Published

2021-02-16

How to Cite

Giavedoni, P., Martinez, C., Podlipnik, S., Suárez-Lleidó, M., Martí-Martí, I., Morgado-Carrasco, D., Rovira, M., Fernández-Avilés, F.-A., Gutiérrez, G., Rosiñol, L., Cid, J., Lozano, M., & Mascaró Jr., J. M. (2021). Assessment of Sclerodermoid Chronic Graft-versus-host Disease with Colour Doppler Ultrasound. Acta Dermato-Venereologica, 101(2), adv00395. https://doi.org/10.2340/00015555-3747