Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis

Authors

  • Camilla Pasternack Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
  • Kaisa Hervonen Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland & Department of Dermatology, Tampere University Hospital, Tampere, Finland
  • Eriika Mansikka Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
  • Timo Reunala Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
  • Katri Kaukinen Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland & Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
  • Teea Salmi Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland & Department of Dermatology, Tampere University Hospital, Tampere, Finland

DOI:

https://doi.org/10.2340/actadv.v102.1072

Keywords:

dermatitis herpetiformis, gluten-free diet, gastrointestinal symptoms, quality of life, sex differences

Abstract

Dermatitis herpetiformis is a blistering autoimmune skin disease, and a cutaneous manifestation of coeliac disease. The burden of coeliac disease is increased especially in females, but studies concerning sex differences in patients with long-term treated dermatitis herpetiformis are scarce. This questionnaire study compared adherence to a gluten-free diet, clinical symptoms and well-being between females and males in a cohort of 237 long-term treated (median 24 years) patients with dermatitis herpetiformis. Females had better adherence to a gluten-free diet (p = 0.022) and they used dapsone significantly less often at the time of the study than did males (4% vs 13%, p = 0.017). The occurrence of skin symptoms was equal in both sexes, but dermatological quality of life was lower in females (p = 0.024), and gastrointestinal symptoms were more severe among females with dermatitis herpetiformis than among males (p = 0.027). In conclusion, long-term treated female patients with dermatitis herpetiformis have better adherence to a gluten-free diet, but they also experience more severe clinical symptoms compared with males.

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References

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Published

2022-05-16

How to Cite

Pasternack, C., Hervonen, K., Mansikka, E., Reunala, T., Kaukinen, K., & Salmi, T. (2022). Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis. Acta Dermato-Venereologica, 102, adv00713. https://doi.org/10.2340/actadv.v102.1072