Lebrikizumab Combined with Topical Corticosteroids Improves Patient-reported Outcomes in Japanese Patients with Moderate-to-severe Atopic Dermatitis

Authors

  • Akio Tanaka Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  • Ken Igawa Dokkyo Medical University, Dokkyo, Japan
  • Hidetoshi Takahashi Takagi Dermatology Clinic, Japan
  • Ryosuke Shimizu Shimizu Dermatology Clinic, Japan
  • Yoko Kataoka Osaka Habikino Medical Center, Osaka, Japan
  • Hitoe Torisu-Itakura Eli Lilly Japan K.K., Kobe, Japan
  • Yoji Morisaki Eli Lilly Japan K.K., Kobe, Japan
  • Sonia Montmayeur Eli Lilly and Company, Indianapolis, IN, USA
  • Norito Katoh Kyoto Prefectural University of Medicine, Kyoto, Japan

DOI:

https://doi.org/10.2340/actadv.v104.34375

Keywords:

Lebrikizumab, Moderate-to-severe AD, Japanese patients, Patient-reported outcomes

Abstract

Lebrikizumab has previously demonstrated efficacy in Phase 3 trials: ADvocate1 and ADvocate2 (as monotherapy), ADhere, and ADhere-J (in combination with topical corticosteroids). Here, the impact of lebrikizumab combined with low- to mid-potency topical corticosteroids on patient-reported outcomes at 16 weeks in Japanese patients with moderate-to-severe atopic dermatitis is evaluated. Eligible patients (n =286) were randomized 2:2:3 to receive placebo+ topical corticosteroids, 250 mg lebrikizumab every 4 weeks (LEBQ4W+topical corticosteroids, 500 mg loading dose at baseline), or 250 mg lebrikizumab every 2 weeks (LEBQ2W+ topical corticosteroids, 500 mg loading dose at baseline and Week 2) by subcutaneous injection. All PRO endpoints for the study were met; patients in the lebrikizumab in combination with topical corticosteroids groups demonstrated statistically significant and clinically meaningful improvements compared with placebo in combination with topical corticosteroids in Skin Pain NRS, DLQI, POEM, WPAI-AD, and SCORAD scales. Lebrikizumab combined with topical corticosteroids compared with placebo+topical corticosteroids improved patient-reported outcomes in Japanese patients with moderate-to-severe atopic dermatitis.

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References

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Published

2024-09-09

How to Cite

Tanaka, A., Igawa, K., Takahashi, H. ., Shimizu, R., Kataoka, Y., Torisu-Itakura, H., … Katoh, N. . (2024). Lebrikizumab Combined with Topical Corticosteroids Improves Patient-reported Outcomes in Japanese Patients with Moderate-to-severe Atopic Dermatitis. Acta Dermato-Venereologica, 104, adv34375. https://doi.org/10.2340/actadv.v104.34375

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