Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients

Authors

  • Marion Chavez-Bourgeois Hospital Clinic Barcelona
  • Simone Ribero
  • Alicia Barreiro
  • Natalia Espinoza
  • Cristina Carrera
  • Adriana Garcia
  • Llucia Alos
  • Susana Puig Melanoma Unit, Dermatology Department, Hospital Clinic Barcelona, Villarroel 170, ES-08036, Barcelona, Spain
  • Josep Malvehy

DOI:

https://doi.org/10.2340/actadv.v102.1105

Keywords:

melanoma, dermoscopy, Electrical Impedance Spectroscopy, reflectance confocal microscopy

Abstract

Electrical impedance spectroscopy has clinical relevance in diagnosing malignancy in melanocytic lesions. Sixty-eight lesions with changes during digital follow-up of patients at very high risk of developing melanoma were prospectively included in this study from February to December 2016. Electrical impedance spectroscopy and reflectance confocal microscopy were performed to evaluate their performance in this subset of difficult lesions. Forty-six lesions were considered suspicious on reflectance confocal microscopy and were excised, of these, 19 were diagnosed as melanoma. Fifteen melanomas were detected by electrical impedance spectroscopy, while 4 received a score lower than 4, which suggested no malignancy. The addition of reflectance confocal microscopy improves accuracy while maintaining the same sensitivity. In the case of electrical impedance spectroscopy scores <4, lesions exhibiting changes in follow-up may need short-term monitoring or excision if dermoscopy shows criteria for melanoma. Results of electrical impedance spectroscopy in this subset of very early lesions should be carefully considered due to the risk of false negatives.

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References

Malvehy J, Puig S. Follow-up of melanocytic skin lesions with digital total-body photography and digital dermoscopy: a two-step method. Clin Dermatol 2002; 20: 297-304.

https://doi.org/10.1016/S0738-081X(02)00220-1

Salerni G, Carrera C, Lovatto L, Puig-Butille J A, Badenas C, Plana E, et al. Benefits of total body photography and digital dermatoscopy ("two-step method of digital follow-up") in the early diagnosis of melanoma in patients at high risk for melanoma. J Am Acad Dermatol 2012; 67: e17-e27.

https://doi.org/10.1016/j.jaad.2011.04.008

Moloney FJ, Guitera P, Coates E,Haass N, Ho K, Khoury R, et al. Detection of primary melanoma in individuals at extreme high risk: a prospective 5-year follow-up study. JAMA Dermatol 2014; 150: 819-827.

https://doi.org/10.1001/jamadermatol.2014.514

Tromme I, Devleesschauwer B, Beutels P, Richez P, Praet N, Sacré L, et al. Selective use of sequential digital dermoscopy imaging allows a cost reduction in the melanoma detection process: a Belgian study of patients with a single or a small number of atypical nevi. PLoS ONE 2014;9: e109339-e109339.

https://doi.org/10.1371/journal.pone.0109339

Lovatto L, Carrera C, Salerni G, Alós L, Malvehy J, Puig S. In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow-up. J Eur Acad Dermatology Venereol 2015; 29: 1918-1925.

https://doi.org/10.1111/jdv.13067

Stanganelli I, Longo C, Mazzoni L, Magi S, Medri M, Lanzanova G, et al. Integration of reflectance confocal microscopy in sequential dermoscopy follow-up improves melanoma detection accuracy. Br J Dermatol 2015; 172: 365-371.

https://doi.org/10.1111/bjd.13373

Aberg P, Nicander I, Hansson J, Geladi P, Holmgren U, Ollmar S. Skin cancer identification using multifrequency electrical impedance - a potential screening tool. IEEE Trans Biomed Eng 2004; 51: 2097-2102.

https://doi.org/10.1109/TBME.2004.836523

Mohr P, Birgersson U, Berking C, Henderson C, Trefzer U, Lajos K, et al. Electrical impedance spectroscopy as a potential adjunct diagnostic tool for cutaneous melanoma. Ski Res Technol 2013; 19: 75-83.

https://doi.org/10.1111/srt.12008

Malvehy J, Hauschild A, Curiel-Lewandrowski C, Mohr P, Hofmann-Wellenhof R, Motley R, et al. Clinical performance of the Nevisense system in cutaneous melanoma detection: An international, multicentre, prospective and blinded clinical trial on efficacy and safety. Br J Dermatol 2014; 171: 1099-1107.

https://doi.org/10.1111/bjd.13121

Rocha L, Menzies SW, Lo S, Avramidis M, Khoury R, Jackett L, et al. Analysis of an electrical impedance spectroscopy system in short-term digital dermoscopy imaging of melanocytic lesions. Br J Dermatol 2017; 177: 1432-1438.

https://doi.org/10.1111/bjd.15595

Salerni G, Carrera C, Lovatto L, Martí-Laborda RM, Isern G, Palou J, et al. Characterization of 1152 lesions excised over 10 years using total-body photography and digital dermatoscopy in the surveillance of patients at high risk for melanoma. J Am Acad Dermatol 2012; 67: 836-845.

https://doi.org/10.1016/j.jaad.2012.01.028

Carrera C, Marchetti MA, Dusza SW, Argenziano G, Braun RP, Halpern AC, et al. Validity and reliability of dermoscopic criteria used to differentiate nevi from melanoma a web-based international dermoscopy society study. JAMA Dermatol 2016; 10022: 1-9.

https://doi.org/10.1001/jamadermatol.2016.0624

Edwards SJ, Osei-Assibey G, Patalay R, Wakefield V, Karner C. Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review. Clin Exp Dermatol 2017; 42: 266-275.

https://doi.org/10.1111/ced.13055

Svoboda RM, Prado G, Mirsky RS, Rigel DS. Assessment of clinician accuracy for diagnosing melanoma on basis of electrical impedance spectroscopy score plus morphology versus lesion morphology alone. J Am Acad Dermatol 2019; 80: 285-287.

https://doi.org/10.1016/j.jaad.2018.08.048

Haenssle HA, Korpas B, Hansen-Hagge C, Buhl T, Kaune KM, Johnsen S, et al. Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors. Arch Dermatol 2010; 146: 257-264.

https://doi.org/10.1001/archdermatol.2009.370

Carrera C, Palou J, Malvehy J, Segura S, Aguilera P, Salerni G, et al. Early stages of melanoma on the limbs of high-risk patients: clinical, dermoscopic, reflectance confocal microscopy and histopathological characterization for improved recognition. Acta Derm Venereol 2011; 91: 137-146.

https://doi.org/10.2340/00015555-1021

Zalaudek I, Nowotny T, Kittler H, Hofmann-Wellenhof R, Massone C. The brown and black rule: a simple clue to differentiate common naevi from spitzoid neoplasms with a dermoscopic uniform globular (clod) pattern. J Eur Acad Dermatology Venereol 2016; 30: 875-876.

https://doi.org/10.1111/jdv.13041

Alarcon I, Carrera C, Palou J, Alos L, Malvehy J, Puig S. Impact of in vivo reflectance confocal microscopy on the number needed to treat melanoma in doubtful lesions. Br J Dermatol 2014; 170: 802-808.

https://doi.org/10.1111/bjd.12678

Pellacani G, Pepe P, Casari A, Longo C. Reflectance confocal microscopy as a second-level examination in skin oncology improves diagnostic accuracy and saves unnecessary excisions: a longitudinal prospective study. Br J Dermatol 2014; 171: 1044-1051.

https://doi.org/10.1111/bjd.13148

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Published

2022-07-26

How to Cite

Chavez-Bourgeois, M., Ribero, S., Barreiro, A., Espinoza, N., Carrera, C., Garcia, A., Alos, L., Puig, S., & Malvehy, J. (2022). Reflectance Confocal Microscopy and Electrical Impedance Spectroscopy in the Early Detection of Melanoma in Changing Lesions during Long-term Follow-up of Very High-risk Patients. Acta Dermato-Venereologica, 102, adv00751. https://doi.org/10.2340/actadv.v102.1105

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