Role of Eosinophil Relative Count and Neutrophil-to-Lymphocyte Ratio in the Assessment of Severity of Atopic Dermatitis

Authors

  • Sanae Inokuchi-Sakata
  • Yozo Ishiuji
  • Michie Katsuta
  • Budiman Kharma
  • Ken-ichi Yasuda
  • Mitsutoshi Tominaga
  • Kenji Takamori
  • Yoshimasa Nobeyama Department of Dermatology, The Jikei University School of Medicine, 105-8461 Tokyo, Japan
  • Akihiko Asahina

DOI:

https://doi.org/10.2340/00015555-3838

Keywords:

atopic dermatitis, subjective parameters, objective parameters, itch, neutrophil-to-lymphocyte ratio, eosinophil relative count

Abstract

The aim of this study is to elucidate the relationship between 2 different types of severity-indicating parameters (i.e. between subjective and objective severity-indicating parametersin patients with atopic dermatitis. The disease severity of 55 patients with atopic dermatitis was assessed using 7 subjective parameters indicating severity, including visual analogue scale for itch, Patient-Oriented Eczema Measure, 5-D itch scale, Dermatology Life Quality Index, Eczema Area and Severity Index, body surface area, and Investigator Global Assessment, and 8 objective parameters indicating severity, including eosinophil relative count, neutrophil-to-lymphocyte ratio, lactate dehydrogenase, and thymus and activation-regulated chemokine. Five subjective parameters reflecting itch correlated significantly with eosinophil relative count, but not with neutrophil-to-lymphocyte ratio. In contrast, 2 subjective parameters, mainly reflecting the degree of inflammation and area of affected regions, correlated significantly with neutrophil-to-lymphocyte ratio. The eosinophil relative count may correlate with the degree of itch, while the neutrophil-to-lymphocyte ratio may correlate with the degree of inflammation and the area of the affected region. The eosinophil relative count and neutrophil-to-lymphocyte ratio may thus be stand-alone parameters from each other in the assessment of the severity of atopic dermatitis.

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Additional Files

Published

2021-07-07

How to Cite

Inokuchi-Sakata, S., Ishiuji, Y., Katsuta, M., Kharma, B., Yasuda, K.- ichi, Tominaga, M., … Asahina, A. (2021). Role of Eosinophil Relative Count and Neutrophil-to-Lymphocyte Ratio in the Assessment of Severity of Atopic Dermatitis. Acta Dermato-Venereologica, 101(7), adv00491. https://doi.org/10.2340/00015555-3838