Intracellular distribution of dopa and 5-S-cysteinyldopa in pigment cells with minimal pigment formation
DOI:
https://doi.org/10.2340/0001555559355356Abstract
The hypothesis that only melanosomal catecholic amino acids contribute to melanin formation was tested by studying adult bovine eyes in which pigment synthesis is considered to be low or absent. Dopa and 5-S-cysteinyldopa were investigated in different cell fractions of the choroid and retinal pigment epithelium of cattle. Most of the dopa and 5-S-cysteinyldopa was found in the cytoplasm and very little in the large granule fraction. The presence of cysteinyldopa in the adult eye is evidence of tyrosinase activity, but the catechol amino acids in the cytoplasm probably do not give rise to melanin formation. It is assumed that they instead are excreted from the cells.Downloads
Download data is not yet available.
Downloads
Published
1979-07-01
How to Cite
Agrup, G., Hansson, C., Rorsman, H., Rosengren, A., & Rosengren, E. (1979). Intracellular distribution of dopa and 5-S-cysteinyldopa in pigment cells with minimal pigment formation. Acta Dermato-Venereologica, 59(4), 355–356. https://doi.org/10.2340/0001555559355356
Issue
Section
Articles
License
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
