Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study

Authors

  • Hyuck Hoon Kwon
  • Steven Hoseong Yang
  • Joon Lee
  • Byung Cheol Park
  • Kui Young Park
  • Jae Yoon Jung
  • Youin Bae
  • Gyeong-Hun Park

DOI:

https://doi.org/10.2340/00015555-3666

Keywords:

adipose tissue stem cell-derived exosomes, acne scar, fractional laser

Abstract

A variety of applications of human adipose tissue stem cell-derived exosomes have been suggested as novel cell-free therapeutic strategies in the regenerative and aesthetic medical fields. This study evaluated the clinical efficacy and safety of adipose tissue stem cell-derived exosomes as an adjuvant therapy after application of fractional CO2 laser for acne scars. A 12-week prospective, double-blind, randomized, split-face trial was performed. A total of 25 patients received 3 consecutive treatment sessions of fractional CO2 laser to the whole face, with a follow-up evaluation. Post-laser treatment regimens were applied; for each patient, one side of the face was treated with adipose tissue stem cell-derived exosomes gel and the other side was treated with control gel. Adipose tissue stem cell-derived exosomes-treated sides had achieved a significantly greater improvement than the control sides at the final follow-up visit (percentage reduction in ?chelle d??valuation clinique des cicatrices d?acn? scores: 32.5 vs 19.9%, p?<?0.01). Treatment-related erythema was milder, and post-treatment downtime was shorter on the applications of human adipose tissue stem cell-derived exosomes-treated side. In conclusion, the combined use of this novel material with resurfacing devices would provide synergistic effects on both the efficacy and safety of atrophic acne scar treatments.

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Published

2020-11-04

How to Cite

Hoon Kwon, H., Yang, S. H., Lee, J., Park, B. C., Park, K. Y., Jung, J. Y., Bae, Y., & Park, G.-H. (2020). Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study. Acta Dermato-Venereologica, 100(18), 1–8. https://doi.org/10.2340/00015555-3666

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Articles