Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients

Authors

  • Ayelet Ollech
  • Michal Solomon
  • Amir Horev
  • Shiran Reiss-Huss
  • Dan Ben-Amitai
  • Alex Zvulunov
  • Rivka Friedland
  • Vered Atar-Snir
  • Vered Pessach-Molho
  • Aviv Barzilai
  • Shoshana Greenberger

DOI:

https://doi.org/10.2340/00015555-3669

Keywords:

leishmaniasis, Leishmania tropica, Leishmania major, miltefosine, amphotericin B, sodium stibogluconate

Abstract

Cutaneous leishmaniasis poses a therapeutic challenge in the paediatric population. The aim of this study was to assess the efficacy and safety of miltefosine treatment for Old World cutaneous leishmaniasis in paediatric patients. A multicentre retrospective review of 10 children (??18 years of age) with cutaneous leishmaniasis treated with miltefosine in Israel was performed. Mean???standard deviation age at diagnosis was 9.1???5.0 years. The Leishmania species diagnosed was L. tropica in 8 cases and Leishmania major in 2 cases. Mean???standard deviation duration of treatment was 44.8???20.6 days, with a mean follow-up period of 12.1???17.1 months. Complete response was noted in 8 (80%) patients. Treatment failure was noted in 2 (20%) cases. Side-effects related to the medication were minimal. In conclusion, oral miltefosine may be an effective and safe treatment for Old World cutaneous leishmaniasis caused by Leishmania tropica or Leishmania major in children. However, further studies are warranted to draw a definite conclusion.

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Published

2020-11-18

How to Cite

Ollech, A., Solomon, M., Horev, A., Reiss-Huss, S., Ben-Amitai, D., Zvulunov, A., … Greenberger, S. (2020). Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients. Acta Dermato-Venereologica, 100(18), 1–5. https://doi.org/10.2340/00015555-3669

Issue

Vol. 100 No. 18 (2020): November

Section

Articles

License

Copyright (c) 2020 Ayelet Ollech, Michal Solomon, Amir Horev, Shiran Reiss-Huss, Dan Ben-Amitai, Alex Zvulunov, Rivka Friedland, Vered Atar-Snir, Vered Pessach-Molho, Aviv Barzilai, Shoshana Greenberger

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