Targeted Combined Endpoint Improvement in Patient and Disease Domains in Atopic Dermatitis: A Treat-to-Target Analysis of Adults with Moderate-to-Severe Atopic Dermatitis Treated with Upadacitinib

Authors

  • Shawn G. Kwatra Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  • Marjolein de Bruin-Weller University Medical Center Utrecht, Utrecht, the Netherlands
  • Jonathan I. Silverberg Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
  • Peter Lio Department of Dermatology & Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
  • Mette Deleuran Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark
  • Handan Aydin AbbVie Inc., North Chicago, IL, USA
  • Brian M. Calimlim AbbVie Inc., North Chicago, IL, USA
  • Michael C. Lane AbbVie Inc., North Chicago, IL, USA
  • Yingyi Liu AbbVie Inc., North Chicago, IL, USA
  • Sarah Ofori AbbVie Inc., North Chicago, IL, USA
  • Stephan Weidinger Department of Dermatology and Allergy, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany

DOI:

https://doi.org/10.2340/actadv.v104.18452

Keywords:

atopic dermatitis, itch, Janus kinase inhibitor, skin clearance, treat-to-target, upadacitinib

Abstract

A treat-to-target approach was recently developed to guide systemic treatment for adults with atopic dermatitis (AD). Recommendations outlined criteria for a 3-month initial acceptable treatment target and a 6-month optimal target, evaluated using global assessment of patient-reported disease severity, as well as Eczema Area and Severity Index, itch assessed on an 11-point numerical rating scale, Dermatology Life Quality Index, or Patient-Oriented Eczema Measure. Achievement of these targets with once-daily upadacitinib (15 mg and 30 mg) monotherapy was evaluated using integrated adult data from the Measure Up 1 and 2 phase 3 studies. Among the 852 patients treated with upadacitinib 15 mg or 30 mg, the 3-month initial acceptable target was achieved by >80%, >78%, and ≥87% of patients, and the 6-month optimal target was achieved by ≥53%, >61%, and >73% of patients at weeks 2, 16, and 52, respectively. Achievement of all 6 individual criteria for each of the target goals also increased over time. These findings suggest that upadacitinib 15 mg and 30 mg may help improve standards of care in patients with moderate-to-severe AD by achieving 6-month target goals at 16 weeks and as early as 2 weeks for most patients.

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Additional Files

Published

2024-05-06

How to Cite

Kwatra, S. G., de Bruin-Weller, M., Silverberg, J. I., Lio, P., Deleuran, M., Aydin, H., … Weidinger, S. (2024). Targeted Combined Endpoint Improvement in Patient and Disease Domains in Atopic Dermatitis: A Treat-to-Target Analysis of Adults with Moderate-to-Severe Atopic Dermatitis Treated with Upadacitinib. Acta Dermato-Venereologica, 104, adv18452. https://doi.org/10.2340/actadv.v104.18452