A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification


  • Yue-Tong Qian
  • Jia-Wei Liu
  • Wei Liu
  • Tian Chen
  • Yan Tan
  • Dong-Lai Ma Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, No.1, Shuaifuyuan, Dongcheng District, Beijing 100730, China




elastolytic giant cell granuloma, annular elastolytic giant cell granuloma, actinic granuloma, elastolysis, elastophagocytosis


Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have been reported. The aims of this retrospective study of 105 patients were to summarize the clinical and histological features of patients with this condition; to provide evidence for the viewpoint that elastolytic giant cell granuloma is a better term to include all clinical morphological types presenting with elastolysis, elastophagocytosis, and an infiltrate of multinucleated giant cells histologically; and to establish a new clinical classification. The varying clinical manifestations were further categorized into annular, papular, giant, mixed and generalized forms. The pathological manifestations were classified into giant cell, necrobiotic, histiocytic, sarcoidal and mixed patterns. Diabetes mellitus or impaired glucose tolerance were the most commonly identified comorbidities. Oral low-dose corticosteroid may be an effective treatment.


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How to Cite

Qian, Y.-T., Liu, J.-W., Liu, W., Chen, T., Tan, Y., & Ma, D.-L. (2022). A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification. Acta Dermato-Venereologica, 102, adv00684. https://doi.org/10.2340/actadv.v102.1985