Mucocutaneous Adverse Reactions to COVID-19 Vaccines: Do Excipients Play a Role?

Authors

  • Leonardo Bianchi Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Filippo Biondi Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Katharina Hansel Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Nicola Murgia Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, Italy
  • Alessandro D'Arpino Hospital Pharmacy Unit, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Italy
  • Marta Tramontana Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Luca Stingeni Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy

DOI:

https://doi.org/10.2340/actadv.v102.2048

Keywords:

COVID-19 vaccine, adverse drug reaction, pure excipients, skin test, patch test, skin prick test, intradermal test

Abstract

Abstract is missing (Short communication)

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References

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https://doi.org/10.1111/bjd.20639

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https://doi.org/10.1111/all.14739

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Bianchi L, Biondi F, Hansel K, Murgia N, Tramontana M, Stingeni L. Skin tests in urticaria/angioedema and flushing to Pfizer-BioNTech SARS-CoV-2 vaccine: Limits of intradermal testing. Allergy 2021; 76: 2605-2607.

https://doi.org/10.1111/all.14839

Mortz CG, Kjaer HF, Rasmussen TH, Rasmussen TH, Garvey LH, Bindslev-Jensen C. Allergy to polyethylene glycol and polysorbates in a patient cohort: diagnostic work-up and decision points for vaccination during the COVID-19 pandemic. Clin Transl Allergy 2022; 12: e12111.

https://doi.org/10.1002/clt2.12111

Wolfson AR, Robinson LB, Li L, McMahon AE, Cogan AS, Fu X, et al. First-dose mRNA COVID-19 vaccine allergic reactions: limited role for excipient skin testing. J Allergy Clin Immunol Pract 2021; 9: 3308-3320.

https://doi.org/10.1016/j.jaip.2021.06.010

Greenhawt M, Shaker M, Golden DBK. PEG/polysorbate skin testing has no utility in the assessment of suspected allergic reactions to SARS-CoV-2 vaccines. J Allergy Clin Immunol Pract 2021; 9: 3321-3322.

https://doi.org/10.1016/j.jaip.2021.06.025

Ieven T, Van Weyenbergh T, Vandebotermet M, Devolder D, Breynaert C, Schrijvers R. Tolerability of polysorbate 80 containing COVID-19 vaccines in confirmed PEG allergic patients. J Allergy Clin Immunol Pract 2021; 9: 4470-4472.e1.

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https://doi.org/10.1111/jdv.17744

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Published

2022-05-24

How to Cite

Bianchi, L., Biondi, F., Hansel, K., Murgia, N., D’Arpino, A., Tramontana, M., & Stingeni, L. (2022). Mucocutaneous Adverse Reactions to COVID-19 Vaccines: Do Excipients Play a Role?. Acta Dermato-Venereologica, 102, adv00724. https://doi.org/10.2340/actadv.v102.2048

Issue

Vol. 102 (2022)

Section

Short Communication

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Copyright (c) 2022 Leonardo Bianchi, Filippo Biondi, Katharina Hansel, Nicola Murgia, Alessandro D'Arpino, Marta Tramontana, Luca Stingeni

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.