Mucocutaneous Adverse Reactions to COVID-19 Vaccines: Do Excipients Play a Role?

Authors

  • Leonardo Bianchi Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Filippo Biondi Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Katharina Hansel Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Nicola Murgia Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia, Italy
  • Alessandro D'Arpino Hospital Pharmacy Unit, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Italy
  • Marta Tramontana Dermatology Section, Department of Medicine and Surgery, University of Perugia, Italy
  • Luca Stingeni Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy

DOI:

https://doi.org/10.2340/actadv.v102.2048

Keywords:

COVID-19 vaccine, adverse drug reaction, pure excipients, skin test, patch test, skin prick test, intradermal test

Abstract

Abstract is missing (Short communication)

Downloads

Download data is not yet available.

References

Pajon R, Doria-Rose NA, Shen X, Schmidt SD, O'Dell S, McDanal C, et al. SARS-CoV-2 omicron variant neutralization after mRNA-1273 booster vaccination. N Engl J Med 2022; 386: 1088-1091.

https://doi.org/10.1056/NEJMc2119912

Greenhawt M, Abrams EM, Shaker M, Chu DK, Khan D, Akin C, et al. The risk of allergic reaction to SARS-CoV-2 vaccines and recommended evaluation and management: a systematic review, meta-analysis, GRADE assessment, and international consensus approach. J Allergy Clin Immunol Pract 2021; 9: 3546-3567.

https://doi.org/10.1016/j.jaip.2021.06.006

Català A, Muñoz-Santos C, Galván-Casas C, Roncero Riesco M, Revilla Nebreda D, Solá-Truyols A, et al. Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases. Br J Dermatol 2022; 186: 142-152.

https://doi.org/10.1111/bjd.20639

Sokolowska M, Eiwegger T, Ollert M, Torres MJ, Barber D, Del Giacco S, et al. EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines. Allergy 2021; 76: 1629-1639.

https://doi.org/10.1111/all.14739

Caballero ML, Quirce S. Excipients as potential agents of anaphylaxis in vaccines: analyzing the formulations of currently authorized COVID-19 vaccines. J Investig Allergol Clin Immunol 2021; 31: 92-93.

https://doi.org/10.18176/jiaci.0667

Stingeni L, Bianchi L, Tramontana M, Pigatto PD, Patruno C, Corazza M, et al. Skin tests in the diagnosis of adverse drug reactions. G Ital Dermatol Venereol 2020; 155: 602-621.

https://doi.org/10.23736/S0392-0488.20.06698-5

Barbaud A, Gonçalo M, Bruynzeel D, Bircher A; European Society of Contact Dermatitis. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions. Contact Dermatitis 2001; 45: 321-328.

https://doi.org/10.1034/j.1600-0536.2001.450601.x

Bianchi L, Biondi F, Hansel K, Murgia N, Tramontana M, Stingeni L. Skin tests in urticaria/angioedema and flushing to Pfizer-BioNTech SARS-CoV-2 vaccine: Limits of intradermal testing. Allergy 2021; 76: 2605-2607.

https://doi.org/10.1111/all.14839

Mortz CG, Kjaer HF, Rasmussen TH, Rasmussen TH, Garvey LH, Bindslev-Jensen C. Allergy to polyethylene glycol and polysorbates in a patient cohort: diagnostic work-up and decision points for vaccination during the COVID-19 pandemic. Clin Transl Allergy 2022; 12: e12111.

https://doi.org/10.1002/clt2.12111

Wolfson AR, Robinson LB, Li L, McMahon AE, Cogan AS, Fu X, et al. First-dose mRNA COVID-19 vaccine allergic reactions: limited role for excipient skin testing. J Allergy Clin Immunol Pract 2021; 9: 3308-3320.

https://doi.org/10.1016/j.jaip.2021.06.010

Greenhawt M, Shaker M, Golden DBK. PEG/polysorbate skin testing has no utility in the assessment of suspected allergic reactions to SARS-CoV-2 vaccines. J Allergy Clin Immunol Pract 2021; 9: 3321-3322.

https://doi.org/10.1016/j.jaip.2021.06.025

Ieven T, Van Weyenbergh T, Vandebotermet M, Devolder D, Breynaert C, Schrijvers R. Tolerability of polysorbate 80 containing COVID-19 vaccines in confirmed PEG allergic patients. J Allergy Clin Immunol Pract 2021; 9: 4470-4472.e1.

https://doi.org/10.1016/j.jaip.2021.09.039

Wenande E, Garvey LH. Immediate-type hypersensitivity to polyethylene glycols: a review. Clin Exp Allergy 2016; 46: 907-922.

https://doi.org/10.1111/cea.12760

Gambichler T, Boms S, Susok L, Dickel H, Finis C, Rached NA, et al. Cutaneous findings following COVID-19 vaccination: review of world literature and own experience. J Eur Acad Dermatol Venereol 2022; 36: 172-180.

https://doi.org/10.1111/jdv.17744

Downloads

Additional Files

Published

2022-05-24

How to Cite

Bianchi, L., Biondi, F., Hansel, K., Murgia, N., D’Arpino, A., Tramontana, M., & Stingeni, L. (2022). Mucocutaneous Adverse Reactions to COVID-19 Vaccines: Do Excipients Play a Role?. Acta Dermato-Venereologica, 102, adv00724. https://doi.org/10.2340/actadv.v102.2048

Issue

Section

Short Communication

Categories