Chilblain-like Lesions after COVID-19 Vaccination: A Case Series


  • Roberto Russo
  • Emanuele Cozzani Section of Dermatology, Department of Health Science (DISSAL), University of Genoa, IT-16132 Genoa, Italy
  • Claudia Micalizzi
  • Aurora Parodi



COVID-19, chilblains, vaccines


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Kanitakis J, Lesort C, Danset M, Jullien D. Chilblain-like acral lesions during the COVID-19 pandemic ("COVID toes"): histologic, immunofluorescence, and immunohistochemical study of 17 cases. J Am Acad Dermatol 2020; 83: 870-875. DOI:

Battesti G, Descamps V. Negative tests for SARS-CoV-2 infection do not rule out its responsibility for chilblains. Br J Dermatol 2020; 183: 1151. DOI:

Hubiche T, Cardot-Leccia N, Le Duff F, Seitz-Polski B, Giordana P, Chiaverini C, et al. Clinical, laboratory, and interferon-alpha response characteristics of patients with chilblain-like lesions during the COVID-19 pandemic. JAMA Dermatol 2021; 157: 202-206. DOI:

Colmenero I, Santonja C, Alonso-Riaño M, Noguera-Morel L, Hernández-Martín A, Andina D, et al. SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases. Br J Dermatol 2020; 183: 729-737. DOI:

Lesort C, Kanitakis J, Donzier L, Jullien D. Chilblain-like lesions after BNT162b2 mRNA COVID-19 vaccine: a case report suggesting that 'COVID toes' are due to the immune reaction to SARS-CoV-2. J Eur Acad Dermatol Venereol 2021; 35: e630-e632. DOI:

Davido B, Mascitti H, Fortier-Beaulieu M, Jaffal K, de Truchis P. 'Blue toes' following vaccination with the BNT162b2 mRNA COVID-19 vaccine. J Travel Med 2021; 28: taab024. DOI:

Meara AS, Silkowski M, Quin K, Jarjour W. A case of chilblains-like lesions post SARS-CoV-2 vaccine? J Rheumatol 2021; 48: 1754. DOI:

Holmes GA, Desai M, Limone B, Love, J, Tawfik M, Wong L, Furukawa B. A case series of cutaneous COVID-19 vaccine reactions at Loma Linda University Department of Dermatology. JAAD Case Rep 2021; 16: 53-57. DOI:

Pileri A, Guglielmo A, Raone B, Patrizi A. Chilblain lesions after COVID-19 mRNA vaccine. Br J Dermatol 2021; 185: e3. DOI:

McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. J Am Acad Dermatol 2021; 85: 46-55. DOI:

Cameli N, Silvestri M, Mariano M, Nisticò SP, Cristaudo A. Pernio-like skin lesions after the second dose of Pfizer-BioNTech COVID-19 vaccine. J Eur Acad Dermatol Venereol 2021; 35: e725-e727. DOI:



How to Cite

Russo, R., Cozzani, E., Micalizzi, C., & Parodi, A. (2022). Chilblain-like Lesions after COVID-19 Vaccination: A Case Series. Acta Dermato-Venereologica, 102, adv00711.