Interleukin-17 Genes Polymorphisms are Significantly Associated with Cutaneous T-cell Lymphoma Susceptibility


  • Karol Kołkowski Dermatological Students Scientific Association, Department of Dermatology, Venerology and Allergology, Faculty of Medicine, Medical University of Gdansk, 17th Str. Smoluchowskiego, PL-80-214 Gdansk, Poland
  • Jolanta Gleń Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Poland;
  • Berenika Olszewska Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Poland;
  • Monika Zabłotna Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Poland;
  • Roman J. Nowicki
  • Małgorzata Sokołowska-Wojdyło Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Poland;



cutaneous lymphoma, mycosis fungoides, Sézary syndrome, lymphoma pathogenesis, single nucleotide polymorphisms, cytokine, interleukin-17


Tumour microenvironment has an important effect on the progression of cutaneous T-cell lymphomas. Using PCR with sequence-specific primers, this study analysed single-nucleotide polymorphisms in the interleukin-17 genes of 150 patients with cutaneous T-cell lymphoma. GG homozygote rs8193036 A/G of interleukin-17A gene occurred less commonly in the cutaneous T-cell lymphoma group; however, patients with this single-nucleotide polymorphism experience significantly intense pruritus. Conversely, the rs2397084 AG heterozygote of interleukin-17F is more common in the lymphoma population. In addition, there were significant differences in the frequencies of interleukin-17 genotypes when comparing early (Ia to IIa) and advanced stages (IIb, III and IV) of this neoplasms. A similar result has been shown in comparison between Sézary syndrome and mycosis fungoides. The current data may serve as a possible explanation for the increased bacterial infection rates in the course of cutaneous T-cell lymphoma, especially caused by Staphylococcus aureus. In summary, specific single-nucleotide polymorphisms occur with different frequencies between cutaneous T-cell lymphoma and healthy patients. Moreover, genetic predisposition of several interleukin-17 single-nucleotide polymorphisms may be a factor causing impaired immune defence in cutaneous lymphomas.


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How to Cite

Kołkowski, K., Jolanta Gleń, Berenika Olszewska, Monika Zabłotna, Nowicki, R. J., & Małgorzata Sokołowska-Wojdyło. (2022). Interleukin-17 Genes Polymorphisms are Significantly Associated with Cutaneous T-cell Lymphoma Susceptibility. Acta Dermato-Venereologica, 102, adv00777.





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