Validation of Relationship between Patients’ Descriptions of Pruritus and Patient-burden of Chronic Pruritus using Structural Equation Modelling

Authors

  • Ji Hoon Ryoo Department of Education, Yonsei University, Seoul, Republic of Korea
  • Seon Hwa Lee Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
  • Dae-Lyong Ha Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
  • Kyung Duck Park Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
  • Jaehee Rho Department of Education, Yonsei University, Seoul, Republic of Korea
  • Gyeong-Hun Park Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea
  • Byung-Soo Kim Department of Dermatology, Pusan National University School of Medicine, Busan, Republic of Korea
  • Kapsok Li Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea
  • Chang Ook Park 6Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
  • Hye One Kim Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea
  • Hei Sung Kim Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Republic of Korea
  • Min Soo Jang 9Department of Dermatology, Kosin University College of Medicine, Busan, Republic of Korea
  • Dong Hun Lee Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea
  • Yang Won Lee Department of Dermatology, Konkuk University School of Medicine, Seoul, Republic of Korea
  • Do Won Kim Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
  • Yong Hyun Jang Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea
  • Seong-Jin Kim Department of Dermatology, Chonnam National University Medical School, Gwangju, Republic of Korea

DOI:

https://doi.org/10.2340/actadv.v102.2527

Keywords:

Chronic itch, Descriptions, Sexual dysfunction, Sleep disturbance, Quality of life

Abstract

Patients with chronic itch describe their pruritus in a wide variety of ways. However, these subjective descriptions are often not taken into consideration by physicians. This study aimed to validate patients’ descriptions of pruritus, and to investigate the relationship between various descriptions of pruritus and the patient burden of chronic pruritus by examining the mediating effects of sleep disturbance and sexual dysfunction on patient’s quality of life, as predicted by various descriptions of pruritus. Exploratory and confirmatory factor analyses were performed to identify the factor structure measured by 11 descriptions of pruritus. The study then analysed differences in the degree of sleep disturbance, sexual dysfunction, and quality of life deterioration factors using a structural equation modelling method. Using data from 419 patients with chronic pruritus, 11 descriptions of pruritus were classified into 2 groups: (i) sensory pruritus (i.e. stinging, stabbing, burning, painful, formication, throbbing, and cold) that are linked with descriptions of pruritus patterns; and (ii) affective pruritus (i.e. annoying, unbearable, worrisome, and warm) from patient reports of psychological or emotional distress. The study found that affective pruritus decreases patient’s quality of life either directly or indirectly through sleep disturbance. In conclusion, clues about a patients’ sleep disturbance or poor quality of life can be obtained through their descriptions of pruritus.

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Published

2022-11-24

How to Cite

Ryoo, J. H., Lee, S. H., Ha, D.-L., Park, K. D., Rho, J., Park, G.-H., Kim, B.-S., Li, K., Park, C. O., Kim, H. O., Kim, H. S., Jang, M. S., Lee, D. H., Lee, Y. W., Kim, D. W., Jang, Y. H., & Kim, S.-J. (2022). Validation of Relationship between Patients’ Descriptions of Pruritus and Patient-burden of Chronic Pruritus using Structural Equation Modelling. Acta Dermato-Venereologica, 102, adv00819. https://doi.org/10.2340/actadv.v102.2527