Determinants of 25-hydroxyvitamin D Status in a Cutaneous Melanoma Population

Authors

  • Julie De Smedt School of Biomedical sciences, Department of Oncology, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
  • Sofie Van Kelst Laboratory of Dermatology, Department of oncology, KU Leuven, 3000 Leuven, Belgium. Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Laudine Janssen Laboratory of Dermatology, Department of oncology, KU Leuven, 3000 Leuven, Belgium. Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Vivien Marasigan Laboratory of Dermatology, Department of oncology, KU Leuven, 3000 Leuven, Belgium. Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium. Department of Surgery, South Infirmary Victoria University Hospital, Cork, Ireland
  • Veerle Boecxstaens Department of Surgical Oncology, University Hospitals KU Leuven, Leuven, Flanders, Belgium.Department of Surgical Oncology, KU Leuven, Leuven, Belgium.
  • Marguerite Stas Department of Surgical Oncology, University Hospitals KU Leuven, Leuven, Flanders, Belgium.Department of Surgical Oncology, KU Leuven, Leuven, Belgium.
  • Dirk Vanderschueren Clinical and Experimental Endocrinology, Department of chronic illnesses and metabolic diseases, KU Leuven, 3000 Leuven, Belgium. Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Ipek Guler Leuven Biostatistics and Statistical Bioinformatics Centre (L‐BioStat), KU Leuven, Leuven, Belgium
  • Kris Bogaerts KU Leuven, Faculty of Medicine, I-BioStat, 3000 Leuven, Belgium and UHasselt, I-BioStat, 3500 Hasselt, Belgium
  • Katleen Vandenberghe Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium
  • Oliver Bechter Laboratory of Experimental Oncology (LEO), Department of Oncology, KU Leuven, 3000 Leuven, Belgium. Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, 3000 Leuven, Belgium.
  • Jaak Billen Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, KU Leuven, Belgium.
  • Arjen Nikkels Department of Dermatology, CHU Sart Tilman, University of Liège, 4000 Liège, Belgium.
  • Tine Strobbe Department of Dermatology, Imelda ziekenhuis, Bonheiden, Belgium
  • Gabriella Emri Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen 4012, Hungary.
  • Diether Lambrechts Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen 4012, Hungary.
  • Marjan Garmyn Laboratory of Dermatology, Department of oncology, KU Leuven, 3000 Leuven, Belgium. Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.

DOI:

https://doi.org/10.2340/actadv.v102.262

Keywords:

melanoma, vitamin D, body mass index

Abstract

Vitamin D status is influenced by well-known determinants, but factors associated with low 25-hydroxyvitamin D levels in the cutaneous melanoma population are not well defined. The aim of this study was to confirm the well-known determinants and to assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. In a prospectively included cohort of 387 patients with cutaneous melanoma the association of 25-hydroxyvitamin D levels with sex, age, body mass index, time of blood withdrawal, Fitzpatrick phototype, vitamin D supplementation, score for intensity of lifetime sun exposure, smoking, education level, hair and skin colour, eye colour, total number of benign naevi, freckles and parameters of chronic sun damage was investigated. In addition, 25-hydroxyvitamin D levels were correlated with pathological parameters of the primary tumour and melanoma stage (8th edition of the American Joint Committee on Cancer (AJCC). Univariate and multivariate logistic regressions were performed using R software. The following factors had a significant effect on vitamin D status: body mass index, seasonal time of blood sampling, vitamin D supplementation, and a subtype of skin, and hair colour.

Downloads

Download data is not yet available.

References

International Agency for Research on Cancer, World Health Organization. Factsheets melanoma, globocan 2020. [accessed January 4th, 2022] Available from: https://gco.iarc.fr/today/data/factsheets/cancers/16-Melanoma-of-skin-fact-sheet.pdf.

Melanoma of the skin - Cancer Stat Facts. National Cancer Institute SEER program. [accessed January 4th, 2022] Available from: https://seer.cancer.gov/statfacts/html/melan.html.

Jeon SM, Shin EA. Exploring vitamin D metabolism and function in cancer. Exp Mol Med 2018; 50: 1-14.

https://doi.org/10.1038/s12276-018-0038-9

Slominski A, Semak I, Zjawiony J, Wortsman J, Li W, Szczesniewski A, et al. The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism. FEBS J 2005; 272: 4080-4090.

https://doi.org/10.1111/j.1742-4658.2005.04819.x

Guryev O, Carvalho RA, Usanov S, Gilep A, Estabrook RW. A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catlysis with cytocrhome P450scc (CYP11A1). Proc Natl Acad Sci USA 2003; 100: 14754-14759.

https://doi.org/10.1073/pnas.2336107100

Slominski AT, Kim TK, Shehabi HZ, Semak I, Tang EK, Nguyen MN, et al. In vivo evidence for a novel pathway of vitamin D- metabolism initiated by P450scc and modified by CYP27B1. FASEB J 2012; 26: 3901-3915.

https://doi.org/10.1096/fj.12-208975

Slominski AT, Li W, Kim TK, Semak I, Wang J, Zjawiony JK, et al. Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol 2015; 151: 25-37.

https://doi.org/10.1016/j.jsbmb.2014.11.010

Slominski AT, Chaiprasongsuk A, Janjetovic Z, Kim TK, Stefan J, Slominski RM, et al. Photoprotective properties of vitamin D and lumisterol hydroxyderivatives. Cell Biochem Biophys 2020; 78: 165-180.

https://doi.org/10.1007/s12013-020-00913-6

Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009; 19: 73-78.

https://doi.org/10.1016/j.annepidem.2007.12.001

Kowalówka M, Główka AK, Karaźniewicz-Łada M, Kosewski G. Clinical significance of analysis of vitamin d status in various diseases. Nutrients 2020; 12: 2788.

https://doi.org/10.3390/nu12092788

Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol 2011; 91: 115-224.

https://doi.org/10.2340/00015555-0980

Vaughan-Shaw PG, O'Sullivan F, Farrington SM, Theodoratou E, Campbell H, Dunlop MG, et al. The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis. Br J Cancer 2017; 116: 1092-1110.

https://doi.org/10.1038/bjc.2017.44

Bouillon R, Van Schoor NM, Gielen E, Boonen S, Mathieu C, Vanderschueren D, et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab 2013; 98: E1283-E1304.

https://doi.org/10.1210/jc.2013-1195

Slominski AT, Brożyna AA, Zmijewski MA, Jóźwicki W, Jetten AM, Mason RS, et al. Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management. Lab Invest 2017; 97: 706-724.

https://doi.org/10.1038/labinvest.2017.3

Slominski AT, Brożyna AA, Skobowiat C, Zmijewski MA, Kim TK, Janjetovic Z, et al. On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol 2018; 177: 159-170.

https://doi.org/10.1016/j.jsbmb.2017.06.013

Newton-Bishop JA, Beswick S, Randerson-Moor J, Chang YM, Affleck P, Elliott F, et al. Serum 25-hydroxyvitamin D3 levels are associated with Breslow thickness at presentation and survival from melanoma. J Clin Oncol 2009; 27: 5439-5444.

https://doi.org/10.1200/JCO.2009.22.1135

Newton-Bishop JA, Davies JR, Latheef F, Randerson-Moor J, Chan M, Gascoyne J, et al. 25-Hydroxyvitamin D2/D3 levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort. Int J Cancer 2015; 136: 2890-2899.

https://doi.org/10.1002/ijc.29334

Gambichler T, Bindsteiner M, Hoxtermann S, Kreuter A. Serum 25-hydroxyvitamin D serum levels in a large German cohort of patients with melanoma. Br J Dermatol 2013; 168: 625-628.

https://doi.org/10.1111/j.1365-2133.2012.11212.x

Bade B, Zdebik A, Wagenpfeil S, Gräber S, Geisel J, Vogt T, et al. Low serum 25-hydroxyvitamin d concentrations are associated with increased risk for melanoma and unfavourable prognosis. PLoS ONE 2014; 9: e112863.

https://doi.org/10.1371/journal.pone.0112863

Wyatt C, Lucas RM, Hurst C, Kimlin MG. Vitamin D deficiency at melanoma diagnosis is associated with higher Breslow thickness. PLoS ONE 2015; 10: e0126394.

https://doi.org/10.1371/journal.pone.0126394

Tierman D, McEnery-Stonelake M, Joyce CJ, Nambudiri VE, Hodi FS, Claus EB, et al. Vitamin D deficiency is associated with a worse prognosis in metastatic melanoma. Oncotarget 2017; 8: 6873-6882.

https://doi.org/10.18632/oncotarget.14316

Fang S, Sui D, Wang Y, Liu H, Chiang YJ, Ross MI, et al. Association of Vitamin D levels with outcome in patients with melanoma after adjustment for C-reactive protein. J Clin Oncol 2016; 34: 1741-1747.

https://doi.org/10.1200/JCO.2015.64.1357

Brożyna AA, Hoffman RM, Slominski AT. Relevance of vitamin D in melanoma development, progression and therapy. Anticancer Res 2020; 40: 473-489.

https://doi.org/10.21873/anticanres.13976

Gershenwald JE, Scolyer RA. Melanoma Staging: American Joint Committee on Cancer (AJCC) 8th Edition and Beyond. Ann Surg Oncol 2018; 25: 2105-2110.

https://doi.org/10.1245/s10434-018-6513-7

De Smedt J, Van Kelst S, Boecxstaens V, Stas M, Bogaerts K, Vanderschueren D, et al. Vitamin D supplementation in cutaneous malignant melanoma outcome (ViDMe): a randomized controlled trial. BMC Cancer 2017; 17: 562.

https://doi.org/10.1186/s12885-017-3538-4

Thomas RL, Jiang L, Adams JS, Xu ZZ, Shen J, Janssen S, et al. Vitamin D metabolites and the gut microbiome in older men. Nat Commun 2020; 11: 5997.

https://doi.org/10.1038/s41467-020-19793-8

Cattaruzza MS, Pisani D, Fidanza L, Gandini S, Marmo G, Narcisi A, et al. 25-Hydroxyvitamin D serum levels and melanoma risk: a case-control study and evidence synthesis of clinical epidemiological studies. Eur J Cancer Prev 2019; 28: 203-211.

https://doi.org/10.1097/CEJ.0000000000000437

Saiag P, Aegerter P, Vitoux D, Lebbé C, Wolkenstein P, Dupin N, et al. Prognostic value of 25-hydroxyvitamin D3 levels at diagnosis and during follow-up in melanoma patients. J Natl Cancer Inst 2015; 107: djv264.

https://doi.org/10.1093/jnci/djv264

Pereira-Santos M, Costa PR, Assis AM, Santos CA, Satnos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev 2015; 16: 341-349.

https://doi.org/10.1111/obr.12239

Walsh JS, Bowles S, Evans AL. Vitamin D in obesity. Curr Opin Endocrinol Diabetes Obes 2017; 24: 389-394.

https://doi.org/10.1097/MED.0000000000000371

Walsh JS, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, et al. Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. Am J Clin Nutr 2016; 103: 1465-1471.

https://doi.org/10.3945/ajcn.115.120139

Macdonald HM, Mavroeidi A, Aucott LA, Diffey BL, Fraser WD, Ormerod AD, et al. Skin color change in Caucasian postmenopausal women predicts summer-winter change in 25-hydroxyvitamin D: findings from the ANSAViD cohort study. J Clin Endocrinol Metab 2011; 96: 1677-1686.

https://doi.org/10.1210/jc.2010-2032

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690-693.

https://doi.org/10.1093/ajcn/72.3.690

Winters SJ, Chennubhatla R, Wang C, Miller JJ. Influence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women. Metabolism 2009; 58: 438-442.

https://doi.org/10.1016/j.metabol.2008.10.017

Lim A, Shayan R, Varigos G. High serum vitamin D level correlates with better prognostic indicators in primary melanoma: a pilot study. Aust J Dermatol 2018; 59: 182-187.

https://doi.org/10.1111/ajd.12648

Lombardo M, Vigezzi A, Ietto G, Franchi C, Lori V, Masci F, et al. Role of vitamin D serum levels in prevention of primary and recurrent melanoma. Sci Rep 2021; 11: 5815.

https://doi.org/10.1038/s41598-021-85294-3

Downloads

Additional Files

Published

2022-04-08

How to Cite

De Smedt, J., Van Kelst, S., Janssen, L., Marasigan, V., Boecxstaens, V., Stas, M., Vanderschueren, D., Guler, I., Bogaerts, K., Vandenberghe, K., Bechter, O., Billen, J., Nikkels, A., Strobbe, T., Emri, G., Lambrechts, D., & Garmyn, M. (2022). Determinants of 25-hydroxyvitamin D Status in a Cutaneous Melanoma Population. Acta Dermato-Venereologica, 102, adv00692. https://doi.org/10.2340/actadv.v102.262

Issue

Section

Articles

Categories