Papain as a Potential New Experimental Model of Non-histaminergic Itch

Authors

  • Giulia Erica Aliotta Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark
  • Zeinab Saii
  • Jesper Elberling
  • Lars Arendt-Nielsen
  • Silvia Lo Vecchio Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Fredrik Bajers Vej 7D, D3-217, DK-9220 Aalborg East, Denmark

DOI:

https://doi.org/10.2340/actadv.v102.2693

Keywords:

itch, papain, non-histaminergic itch

Abstract

Abstract is missing (Short communication)

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References

Ständer S, Weisshaar E, Mettang T, Szepietowski JC, Carstens E, Ikoma A, et al. Clinical classification of itch: a position paper of the International Forum for the Study of Itch. Acta Derm Venereol 2007; 87: 291-294.

https://doi.org/10.2340/00015555-0305

Andersen HH, Elberling J, Arendt-Nielsen L. Human surrogate models of histaminergic and non-histaminergic itch. Acta Derm Venereol 2015; 95: 771-779.

https://doi.org/10.2340/00015555-2146

Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, et al. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A 2009; 106: 11330-11335.

https://doi.org/10.1073/pnas.0905605106

Lee SE, Jeong SK, Lee SH. Protease and protease-activated receptor-2 signaling in the pathogenesis of atopic dermatitis. Yonsei Med J 2010; 51: 808-822.

https://doi.org/10.3349/ymj.2010.51.6.808

Johanek LM, Meyer RA, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, et al. Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci 2007; 27: 7490-7497.

https://doi.org/10.1523/JNEUROSCI.1249-07.2007

Weisshaar E, Kucenic MJ, Fleischer AB. Pruritus: a review. Acta Derm Venereol 2003; Suppl 213: 5-33.

Reddy VB, Lerner EA. Plant cysteine proteases that evoke itch activate protease-activated receptors. Br J Dermatol 2010; 163: 532-535.

https://doi.org/10.1111/j.1365-2133.2010.09862.x

Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 2003; 23: 6176-6180.

https://doi.org/10.1523/JNEUROSCI.23-15-06176.2003

Harju EL. Cold and warmth perception mapped for age, gender, and body area. Somatosens Mot Res 2002; 19: 61-75.

https://doi.org/10.1080/08990220120113057

Wooten M, Weng HJ, Hartke T v, Borzan J, Klein AH, Turnquist B, et al. Three functionally distinct classes of C-fibre nociceptors in primates. Nat Commun 2014; 5: 4122.

https://doi.org/10.1038/ncomms5122

Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE. Specific C-receptors for itch in human skin. J Neurosci 1997; 17: 8003-8008.

https://doi.org/10.1523/JNEUROSCI.17-20-08003.1997

Andersen HH, Akiyama T, Nattkemper LA, van Laarhoven A, Elberling J, Yosipovitch G, et al. Alloknesis and hyperknesis - mechanisms, assessment methodology, and clinical implications of itch sensitization. Pain 2018; 159: 1185-1197.

https://doi.org/10.1097/j.pain.0000000000001220

Dai Y. TRPs and pain. Semin Immunopathol 2015; 38: 277-291.

https://doi.org/10.1007/s00281-015-0526-0

Simone DA, Alreja M, Lamotte RH. Psychophysical studies of the itch sensation and itchy skin ("alloknesis") produced by intracutaneous injection of histamine. Somatosens Mot Res 1991; 8: 271-279.

https://doi.org/10.3109/08990229109144750

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Published

2022-10-04

How to Cite

Aliotta, G. E., Saii, Z. ., Elberling, J., Arendt-Nielsen, L., & Lo Vecchio, S. (2022). Papain as a Potential New Experimental Model of Non-histaminergic Itch. Acta Dermato-Venereologica, 102, adv00786. https://doi.org/10.2340/actadv.v102.2693

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