Living with Atopic Dermatitis as a Young Adult in Relation to Health-related Quality of Life and Healthcare Contacts: A Population-based Study

Authors

  • Susanne Lundin Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Jägargatan 20, SE-118 67 Stockholm, Sweden
  • Anna Bergström Institute of Environmental Medicine & Centre of Occupational and Environmental Medicine
  • Carl-Fredrik Wahlgren Dermatology and Venereology Unit, Department of Medicine
  • Emma K. Johansson Dermatology and Venereology Unit, Department of Medicine & Department of Dermatology
  • Niklas Andersson Institute of Environmental Medicine
  • Natalia Ballardini Department of Clinical Science and Education, Institute of Environmental Medicine & Department of Dermatology and Sexual Health
  • Marina Jonsson Department of Clinical Science and Education & Centre of Occupational and Environmental Medicine
  • Erik Melén Department of Clinical Science and Education, Sach´s Children and Youth Hospital, Södersjukhuset & Institute of Environmental Medicine
  • Inger Kull Department of Clinical Science and Education & Sach´s Children and Youth Hospital, Södersjukhuset

DOI:

https://doi.org/10.2340/actadv.v102.294

Keywords:

Atopic dermatitis, Disease burden, Eczema, Epidemiology, Health-related quality of life

Abstract

Most studies of health-related quality of life (HRQoL) and atopic dermatitis are based on data from dermatology clinics. The aim of this study was to determine whether atopic dermatitis affects HRQoL in adolescence and young adulthood, based on data from the population-based cohort BAMSE (Children, Allergy, Environmental, Stockholm, Epidemiology). A further aim was to determine if the use of topical corticosteroids and healthcare contacts affect HRQoL. Participants with data from birth to young adulthood (n=3,064) were included. Two generic instruments were used to measure HRQoL:General Health at age 12, 16 and 24 years and EQ-5D-3L, including EQ-visual analogue scale (EQ-VAS) at age 24 years. In addition, the disease-specific Dermatology Quality Life Index (DLQI) was used at 24 years. Healthcare consultations for atopic dermatitis were obtained from Stockholm Regional Healthcare Data Warehouse (n = 1,944). Participants with atopic dermatitis had an increased odds ratio (OR) of not feeling completely healthy (adjusted OR 1.50; 95% confidence interval (95% CI): 1.30–1.73). Participants with persistent atopic dermatitis, fulfilling atopic dermatitis criteria in the 12- and/or 16- and 24-year follow-ups reported worse EQ-VAS value 70.0 (95% CI 67.3–72.7) in the 25th percentile, than peers without atopic dermatitis. Over an 8-year period, contact with healthcare was limited (mean number 0.96). In conclusion, atopic dermatitis had a negative impact on HRQoL in young adults from adolescence to adulthood and healthcare consultations were few.

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Author Biographies

Anna Bergström, Institute of Environmental Medicine & Centre of Occupational and Environmental Medicine

Karolinska Institutet & Stockholm County Council, PhD

Carl-Fredrik Wahlgren, Dermatology and Venereology Unit, Department of Medicine

Karolinska Institutet, MD, PhD, Senior Professor

Emma K. Johansson, Dermatology and Venereology Unit, Department of Medicine & Department of Dermatology

Karolinska Institutet & Karolinska University Hospital, MD, PhD

Niklas Andersson, Institute of Environmental Medicine

Karolinska Instiutet, Statistician

Natalia Ballardini, Department of Clinical Science and Education, Institute of Environmental Medicine & Department of Dermatology and Sexual Health

Söderskjukhuset & Karolinska Instiutet, MD, PhD

Marina Jonsson, Department of Clinical Science and Education & Centre of Occupational and Environmental Medicine

Södersjukhuset & Stockholm County Council

Erik Melén, Department of Clinical Science and Education, Sach´s Children and Youth Hospital, Södersjukhuset & Institute of Environmental Medicine

Södersjukhuset, Karolinska Institutet, PhD, Professor

Inger Kull, Department of Clinical Science and Education & Sach´s Children and Youth Hospital, Södersjukhuset

Södersjukhuset, Karolinska Insitutet, PhD, Professor

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Published

2022-05-04

How to Cite

Lundin, S., Bergström, A., Wahlgren, C.-F., Johansson, E. K., Andersson, N., Ballardini, N., Jonsson, M. ., Melén, E., & Kull, I. (2022). Living with Atopic Dermatitis as a Young Adult in Relation to Health-related Quality of Life and Healthcare Contacts: A Population-based Study. Acta Dermato-Venereologica, 102, adv00702. https://doi.org/10.2340/actadv.v102.294

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