Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016

Authors

  • Charlotte B. van Lee
  • Wilner Christopher Kan
  • Sonia Gran
  • Antien Mooyaart
  • Renate van den Bos
  • Marc A.M. Mureau
  • Hywel C. Williams
  • Rubeta Matin
  • Loes M. Hollestein

DOI:

https://doi.org/10.2340/00015555-3287

Keywords:

dermatofibrosarcoma protuberans, recurrence, surgical excision, histological clearance, Mohs micrographic surgery

Abstract

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (<?0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890 instances of dermatofibrosarcoma protuberans included, 87% were treated with excision, 4% with Mohs micrographic surgery, and 9% otherwise or unknown. Linked pathology data were retrieved for 1,677 patients. Half of all excisions (847/1,644) were incomplete and 29% (192/622) of all re-excisions were incomplete. The cumulative incidence of a recurrence was 7% (95% confidence interval (95% CI) 6?8) during a median follow-up of 11 years (interquartile range (IQR) 6?17). After Mohs micrographic surgery (n?=?34), there were no recurrences during a median follow-up of 4 years (IQR 3?6). Due to the high rate of incomplete excisions and recurrences after excision, this study supports the European guideline, which recommends treating dermatofibrosarcoma protuberans with Mohs micrographic surgery in order to decrease the rate of recurrence.

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Published

2019-09-23 — Updated on 2022-09-05

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How to Cite

van Lee, C. B., Kan, W. C., Gran, S., Mooyaart, A., van den Bos, R., Mureau, M. A., … Hollestein, L. M. (2022). Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016. Acta Dermato-Venereologica, 99(12), 1160–1165. https://doi.org/10.2340/00015555-3287 (Original work published September 23, 2019)

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Editorial