Tolerability of Narrow-band Ultraviolet-B Phototherapy for Different Dermatological Diseases in Relation to Co-medications
DOI:
https://doi.org/10.2340/actadv.v104.35215Keywords:
medication, photosensitivity, phototherapy, UV-therapyAbstract
Phototherapy is an efficient therapy for a variety of skin diseases. Various drugs can cause photosensitivity and impact tolerability of phototherapy. The tolerability was investigated of narrowband ultraviolet-B 311 nm therapy in dependence on the underlying disease and long-term co-medication. A total of 534 narrowband ultraviolet-B therapy courses were examined. Compared with psoriasis, adverse events were observed more frequently in eczematous diseases and, in some cases, other indications. About two-thirds of all courses were carried out in patients taking at least one photosensitising drug, according to the summaries of product characteristics. Phototherapy was more frequently associated with adverse events when medication was taken concomitantly. When considering the tolerability of phototherapy in dependence on individual substances or drug classes, no statistically significant result was shown after adjustment.
Downloads
References
Moller KI, Kongshoj B, Philipsen PA, Thomsen VO, Wulf HC. How Finsen's light cured lupus vulgaris. Photodermatol Photoimmunol Photomed 2005; 21: 118-124.
https://doi.org/10.1111/j.1600-0781.2005.00159.x DOI: https://doi.org/10.1111/j.1600-0781.2005.00159.x
Roelandts R. Photodermatology over the past 125 years. Br J Dermatol 2014; 171: 926-928.
https://doi.org/10.1111/bjd.13405 DOI: https://doi.org/10.1111/bjd.13405
Brodsky M, Abrouk M, Lee P, Kelly KM. Revisiting the history and importance of phototherapy in dermatology. JAMA Dermatol 2017; 153: 435.
https://doi.org/10.1001/jamadermatol.2017.0722 DOI: https://doi.org/10.1001/jamadermatol.2017.0722
Vangipuram R, Feldman SR. Ultraviolet phototherapy for cutaneous diseases: a concise review. Oral Dis 2016; 22: 253-259.
https://doi.org/10.1111/odi.12366 DOI: https://doi.org/10.1111/odi.12366
Hannuksela-Svahn A, Sigurgeirsson B, Pukkala E, Lindelof B, Berne B, Hannuksela M, et al. Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. Br J Dermatol 1999; 141: 497-501.
https://doi.org/10.1046/j.1365-2133.1999.03044.x DOI: https://doi.org/10.1046/j.1365-2133.1999.03044.x
Hearn RM, Kerr AC, Rahim KF, Ferguson J, Dawe RS. Incidence of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy. Br J Dermatol 2008; 159: 931-935.
https://doi.org/10.1111/j.1365-2133.2008.08776.x DOI: https://doi.org/10.1111/j.1365-2133.2008.08776.x
Lee E, Koo J, Berger T. UVB phototherapy and skin cancer risk: a review of the literature. Int J Dermatol 2005; 44: 355-360.
https://doi.org/10.1111/j.1365-4632.2004.02186.x DOI: https://doi.org/10.1111/j.1365-4632.2004.02186.x
Shephard SE, Panizzon RG. Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy. Dermatology 1999; 199: 106-112.
https://doi.org/10.1159/000018215 DOI: https://doi.org/10.1159/000018215
Kurz B, Berneburg M, Bäumler W, Karrer S. Phototherapy: theory and practice. J Dtsch Dermatol Ges 2023; 21: 882-897.
https://doi.org/10.1111/ddg.15126 DOI: https://doi.org/10.1111/ddg.15126
Hofmann GA, Weber B. Medikamenten-induzierte Photosensibilität: auslösende Medikamente, mögliche Mechanismen und klinische Folgen. J Dtsch Dermatol Ges 2021; 19: 19-30.
https://doi.org/10.1111/ddg.14314_g DOI: https://doi.org/10.1111/ddg.14314_g
Selvaag E. Clinical drug photosensitivity: a retrospective analysis of reports to the Norwegian Adverse Drug Reactions Committee from the years 1970-1994. Photodermatol Photoimmunol Photomed 1997; 13: 21-23.
https://doi.org/10.1111/j.1600-0781.1997.tb00103.x DOI: https://doi.org/10.1111/j.1600-0781.1997.tb00103.x
Stein KR, Scheinfeld NS. Drug-induced photoallergic and phototoxic reactions. Expert Opin Drug Saf 2007; 6: 431-443.
https://doi.org/10.1517/14740338.6.4.431 DOI: https://doi.org/10.1517/14740338.6.4.431
Beani JC, Jeanmougin M. Narrow-band UVB therapy in psoriasis vulgaris: good practice guideline and recommendations of the French Society of Photodermatology. Ann Dermatol Venereol 2010; 137: 21-31.
https://doi.org/10.1016/j.annder.2009.12.004 DOI: https://doi.org/10.1016/j.annder.2009.12.004
Barros NM, Sbroglio LL, Buffara MO, Baka J, Pessoa AS, Azulay-Abulafia L. Phototherapy. An Bras Dermatol 2021; 96: 397-407.
https://doi.org/10.1016/j.abd.2021.03.001 DOI: https://doi.org/10.1016/j.abd.2021.03.001
Klein A, Schiffner R, Schiffner-Rohe J, Einsele-Krämer B, Heinlin J, Stolz W, et al. A randomized clinical trial in psoriasis: synchronous balneophototherapy with bathing in Dead Sea salt solution plus narrowband UVB vs. narrowband UVB alone (TOMESA-study group). J Eur Acad Dermatol Venereol 2011; 25: 570-578.
https://doi.org/10.1111/j.1468-3083.2010.03840.x DOI: https://doi.org/10.1111/j.1468-3083.2010.03840.x
Eysteinsdóttir JH, Ólafsson JH, Agnarsson BA, Lúðvíksson BR, Sigurgeirsson B. Psoriasis treatment: faster and long-standing results after bathing in geothermal seawater. A randomized trial of three UVB phototherapy regimens. Photodermatol Photoimmunol Photomed 2014; 30: 25-34.
https://doi.org/10.1111/phpp.12090 DOI: https://doi.org/10.1111/phpp.12090
Iversen L, Conrad C, Eidsmo L, Costanzo A, Narbutt J, Pinter A, et al. Secukinumab demonstrates superiority over narrow-band ultraviolet B phototherapy in new-onset moderate to severe plaque psoriasis patients: week 52 results from the STEPIn study. J Eur Acad Dermatol Venereol 2023; 37: 1004-1016.
https://doi.org/10.1111/jdv.18846 DOI: https://doi.org/10.1111/jdv.18846
Koek MB, Buskens E, van Weelden H, Steegmans PH, Bruijnzeel-Koomen CA, Sigurdsson V. Home versus outpatient ultraviolet B phototherapy for mild to severe psoriasis: pragmatic multicentre randomised controlled non-inferiority trial (PLUTO study). BMJ 2009; 338: b1542.
https://doi.org/10.1136/bmj.b1542 DOI: https://doi.org/10.1136/bmj.b1542
Chen WY, Chen SC, Hsu SY, Lin YA, Shih CM, Huang CY, et al. Annoying psoriasis and atopic dermatitis: a narrative review. Int J Mol Sci 2022; 23: 4898.
https://doi.org/10.3390/ijms23094898 DOI: https://doi.org/10.3390/ijms23094898
Tétart F, Joly P. Eczema in elderly people. Eur J Dermatol 2020; 30: 663-667.
https://doi.org/10.1684/ejd.2020.3915 DOI: https://doi.org/10.1684/ejd.2020.3915
Bulur I, Erdogan HK, Aksu AE, Karapınar T, Saracoglu ZN. The efficacy and safety of phototherapy in geriatric patients: a retrospective study. An Bras Dermatol 2018; 93: 33-38.
https://doi.org/10.1590/abd1806-4841.20185468 DOI: https://doi.org/10.1590/abd1806-4841.20185468
Matthews SW, Pike K, Chien AJ. Phototherapy: safe and effective for challenging skin conditions in older adults. Cutis 2021; 108: E15-E21.
https://doi.org/10.12788/cutis.0307 DOI: https://doi.org/10.12788/cutis.0307
Torres AE, Lyons AB, Hamzavi IH, Lim HW. Role of phototherapy in the era of biologics. J Am Acad Dermatol 2021; 84: 479-485.
https://doi.org/10.1016/j.jaad.2020.04.095 DOI: https://doi.org/10.1016/j.jaad.2020.04.095
Patrizi A, Raone B, Ravaioli GM. Safety and efficacy of phototherapy in the management of eczema. Adv Exp Med Biol 2017; 996: 319-331.
https://doi.org/10.1007/978-3-319-56017-5_27 DOI: https://doi.org/10.1007/978-3-319-56017-5_27
Musters AH, Mashayekhi S, Harvey J, Axon E, Lax SJ, Flohr C, et al. Phototherapy for atopic eczema. Cochrane Database Syst Rev 2021; 10: Cd013870.
https://doi.org/10.1002/14651858.CD013870 DOI: https://doi.org/10.1002/14651858.CD013870
Wolf P. The 2022 British guidelines for narrowband ultraviolet B phototherapy: an absolute necessity for anyone administering or prescribing phototherapy. Br J Dermatol 2022; 187: 285-286.
https://doi.org/10.1111/bjd.21735 DOI: https://doi.org/10.1111/bjd.21735
Moore DE. Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management. Drug Saf 2002; 25: 345-372.
https://doi.org/10.2165/00002018-200225050-00004 DOI: https://doi.org/10.2165/00002018-200225050-00004
Schauder S. Phototoxische Reaktionen der Haut durch Medikamente. Deutsches Ärzteblatt 2005; 102: A 2314-2319.
Patrizi A, Raone B, Ravaioli GM. Management of atopic dermatitis: safety and efficacy of phototherapy. Clin Cosmet Investig Dermatol 2015; 8: 511-520.
https://doi.org/10.2147/CCID.S87987 DOI: https://doi.org/10.2147/CCID.S87987
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2024 Anna M. Halupczok, Ann-Sophie Bohne, Sascha Gerdes, Stephan Weidinger, Michael Weichenthal
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
