Treatment of Brachioradial Pruritus: A Tertiary Center Retrospective Analysis
DOI:
https://doi.org/10.2340/actadv.v104.40246Keywords:
brachioradial pruritus, neuropathic pruritus, pruritus, treatmentsAbstract
This retrospective study investigates the efficacy of 2 treatment regimens, pregabalin alone versus pregabalin combined with ketamine, amitriptyline, and lidocaine cream, in reducing itch in patients with brachioradial pruritus at a tertiary care center. Electronic medical records of 64 brachioradial pruritus patients seen at the University of Miami Itch Center were analyzed. A significant reduction in itch scores was seen with both treatments, with no significant difference between the groups. A small number of patients experienced adverse effects, including drowsiness and weight gain with pregabalin and skin irritation with ketamine, amitriptyline, and lidocaine cream. Ultimately, our findings underscore the potential of utilizing combined therapy for difficult-to-treat brachioradial pruritus cases and implementing individualized approaches for managing neuropathic pruritus. Further controlled clinical trials are needed to establish optimal treatment protocols.
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References
Kavanagh KJ, Mattei PL, Lawrence R, Burnette C. Brachioradial pruritus: an etiologic review and treatment summary. Cutis 2023; 112: 84-87.
https://doi.org/10.12788/cutis.0828 DOI: https://doi.org/10.12788/cutis.0828
Kwatra SG, Elmariah S, Chisolm S, Mollanazar N, Fassett M, Cole EF, et al. United States expert panel consensus on uniform nomenclature and diagnosis for neuropathic pruritus. Itch 2024; 9: e0073.
https://doi.org/10.1097/itx.0000000000000073 DOI: https://doi.org/10.1097/itx.0000000000000073
Baka P, Birklein F. Neuropathischer Pruritus - evidenzbasierte Behandlungsempfehlungen. Nervenarzt 2023; 94: 136-141.
https://doi.org/10.1007/s00115-022-01369-0 DOI: https://doi.org/10.1007/s00115-022-01369-0
Sreekantaswamy SA, Mollanazar N, Butler DC. Gabapentinoids for pruritus in older adults: a narrative review. Dermatol Ther (Heidelb) 2021; 11: 669-679.
https://doi.org/10.1007/s13555-021-00513-z DOI: https://doi.org/10.1007/s13555-021-00513-z
Atis G, Bilir Kaya B. Pregabalin treatment of three cases with brachioradial pruritus. Dermatol Ther 2017; 30.
https://doi.org/10.1111/dth.12459 DOI: https://doi.org/10.1111/dth.12459
Zakaria A, Amerson E. Treatment modalities in brachioradial pruritis: a systematic review. Dermatol Online J 2022; 28.
https://doi.org/10.5070/D328458503 DOI: https://doi.org/10.5070/D328458503
Matsuda KM, Sharma D, Schonfeld AR, Kwatra SG. Gabapentin and pregabalin for the treatment of chronic pruritus. J Am Acad Dermatol 2016; 75: 619-625 e616.
https://doi.org/10.1016/j.jaad.2016.02.1237 DOI: https://doi.org/10.1016/j.jaad.2016.02.1237
Lee HG, Grossman SK, Valdes-Rodriguez R, Berenato F, Korbutov J, Chan YH, et al. Topical ketamine-amitriptyline-lidocaine for chronic pruritus: a retrospective study assessing efficacy and tolerability. J Am Acad Dermatol 2017; 76: 760-761.
https://doi.org/10.1016/j.jaad.2016.10.030 DOI: https://doi.org/10.1016/j.jaad.2016.10.030
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Copyright (c) 2024 Kayla D. Mashoudy, Luis F. Andrade, Nicole Khalil, Ellie H. Zhang, Jaxon D. Wagner, Bharat Malhotra, Gil Yosipovitch
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