Diagnostic Value of Optical Coherence Tomography Image Features for Diagnosis of Basal Cell Carcinoma
DOI:
https://doi.org/10.2340/actadv.v101.421Keywords:
basal cell carcinoma, optical coherence tomography, diagnostic, non-invasiveAbstract
Optical coherence tomography (OCT) is a non-invasive diagnostic method. Numerous morphological OCT features have been described for diagnosis of basal cell carcinoma (BCC). The aim of this study is to evaluate the diagnostic value of established OCT features and to explore whether the use of a small set of OCT features enables accurate discrimination between BCC and non-BCC lesions and between BCC subtypes. For each lesion, the presence or absence of specific OCT features was recorded. Histopathology was used as a gold standard. Diagnostic parameters were calculated for each OCT feature, and multivariate logistic regression analyses were performed to evaluate the loss in discriminative ability when using a small subset of OCT features instead of all features that are characteristic for BCC according to the literature. The results show that the use of a limited number of OCT features allows for good discrimination of superficial BCC from non-superficial BCC and non-BCC lesions. The prevalence of BCC was 75.3% (225/299) and the proposed diagnostic algorithm enabled detection of 97.8% of BCC lesions (220/225). Subtyping without the need for biopsy was possible in 132 of 299 patients (44%), with a predictive value for presence of superficial BCC of 84.3% vs 98.8% for presence of non-superficial BCC.
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Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012; 166: 1069-1080.
https://doi.org/10.1111/j.1365-2133.2012.10830.x DOI: https://doi.org/10.1111/j.1365-2133.2012.10830.x
Flohil SC, de Vries E, Neumann HA, Coebergh JW, Nijsten T. Incidence, prevalence and future trends of primary basal cell carcinoma in the Netherlands. Acta Derm Venereol 2011; 91: 24-30.
https://doi.org/10.2340/00015555-1009 DOI: https://doi.org/10.2340/00015555-1009
Flohil SC, Seubring I, van Rossum MM, Coebergh JW, de Vries E, Nijsten T. Trends in Basal cell carcinoma incidence rates: a 37-year Dutch observational study. Invest Dermatol 2013; 133: 913-918.
https://doi.org/10.1038/jid.2012.431 DOI: https://doi.org/10.1038/jid.2012.431
Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the U.S. population, 2012. JAMA Dermatol 2015; 151: 1081-1086.
https://doi.org/10.1001/jamadermatol.2015.1187 DOI: https://doi.org/10.1001/jamadermatol.2015.1187
Rippey JJ. Why classify basal cell carcinomas? Histopathology 1998; 32: 393-398.
https://doi.org/10.1046/j.1365-2559.1998.00431.x DOI: https://doi.org/10.1046/j.1365-2559.1998.00431.x
NVDV. Multi-disciplinary evidence-based guideline basal cel carcinoma. Available from: www.oncoline.nl. Utrecht, 2015.
Cheng HM, Guitera P. Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma. Br J Dermatol 2015; 173: 1371-1380.
https://doi.org/10.1111/bjd.14042 DOI: https://doi.org/10.1111/bjd.14042
Hussain AA, Themstrup L, Jemec GBE. Optical coherence tomography in the diagnosis of basal cell carcinoma. Arch Dermatol Res 2015; 307: 1-10.
https://doi.org/10.1007/s00403-014-1498-y DOI: https://doi.org/10.1007/s00403-014-1498-y
Ulrich M, von Braunmuehl T, Kurzen H, Dirschka T, Kellner C, Sattler E, et al. The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study. Br J Dermatol 2015; 173: 428-435.
https://doi.org/10.1111/bjd.13853 DOI: https://doi.org/10.1111/bjd.13853
Cheng HM, Lo S, Scolyer R, Meekings A, Carlos G, Guitera P. Accuracy of optical coherence tomography for the diagnosis of superficial basal cell carcinoma: a prospective, consecutive, cohort study of 168 cases. Br J Dermatol 2016; 175: 1290-1300.
https://doi.org/10.1111/bjd.14714 DOI: https://doi.org/10.1111/bjd.14714
von Braunmuhl T, Hartmann D, Tietze JK, Cekovic D, Kunte C, Ruzicka T, et al. Morphologic features of basal cell carcinoma using the en-face mode in frequency domain optical coherence tomography. J Eur Acad Dermatol Venereol 2016; 30: 1919-1925.
https://doi.org/10.1111/jdv.13704 DOI: https://doi.org/10.1111/jdv.13704
Wahrlich C, Alawi SA, Batz S, Fluhr JW, Lademann J, Ulrich M. Assessment of a scoring system for basal cell carcinoma with multi-beam optical coherence tomography. J Eur Acad Dermatol Venereol 2015; 29: 1562-1569.
https://doi.org/10.1111/jdv.12935 DOI: https://doi.org/10.1111/jdv.12935
Coleman AJ, Richardson TJ, Orchard G, Uddin A, Choi MJ, Lacy KE. Histological correlates of optical coherence tomography in non-melanoma skin cancer. Skin Res Technol 2013; 19: 10-19.
https://doi.org/10.1111/j.1600-0846.2012.00626.x DOI: https://doi.org/10.1111/j.1600-0846.2012.00626.x
Sattler E, Kastle R, Welzel J. Optical coherence tomography in dermatology. J Biomed Opt 2013; 18: 061224.
https://doi.org/10.1117/1.JBO.18.6.061224 DOI: https://doi.org/10.1117/1.JBO.18.6.061224
DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988; 44: 837-845.
https://doi.org/10.2307/2531595 DOI: https://doi.org/10.2307/2531595
van der Geer S, Frunt M, Romero HL, Dellaert NP, Jansen-Vullers MH, Demeyere TB, et al. One-stop-shop treatment for basal cell carcinoma, part of a new disease management strategy. Eur Acad Dermatol Venereol 2012; 26: 1154-1157.
https://doi.org/10.1111/j.1468-3083.2011.04184.x DOI: https://doi.org/10.1111/j.1468-3083.2011.04184.x
Kadouch DJ, Wolkerstorfer A, Elshot Y, Zupan-Kajcovski B, Crijns MB, Starink MV, et al. Treatment of basal cell carcinoma using a one-stop-shop with reflectance confocal microscopy: study design and protocol of a randomized controlled multicenter trial. JMIR Res Protoc 2015; 4: e109.
https://doi.org/10.2196/resprot.4303 DOI: https://doi.org/10.2196/resprot.4303
Themstrup L, De Carvalho N, Nielsen SM, Olsen J, Ciardo S, Schuh S, et al. In vivo differentiation of common basal cell carcinoma subtypes by microvascular and structural imaging using dynamic optical coherence tomography. Exp Dermatol 2018; 27: 156-165.
https://doi.org/10.1111/exd.13479 DOI: https://doi.org/10.1111/exd.13479
Gambichler T, Orlikov A, Vasa R, Moussa G, Hoffmann K, Stucker M, et al. In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci 2007; 45: 167-173.
https://doi.org/10.1016/j.jdermsci.2006.11.012 DOI: https://doi.org/10.1016/j.jdermsci.2006.11.012
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