Flounder Roe Triggering α-Gal Syndrome: Hyosophorin as a Possible Allergen

Authors

  • Hideo Hashizume Department of Future Wellness (endowed by TAICA Co.), Shizuoka Graduate University of Public Health, Shizuoka, Japan; Division of Dermatology, Iwata City Hospital, Iwata, Japan
  • Ammi Matsuura Department of Future Wellness (endowed by TAICA Co.), Shizuoka Graduate University of Public Health, Shizuoka, Japan
  • Yuto Ishikawa Division of Dermatology, Iwata City Hospital, Iwata, Japan
  • Akihito Hata Division of Dermatology, Iwata City Hospital, Iwata, Japan

DOI:

https://doi.org/10.2340/actadv.v105.42664

Keywords:

food allergy, anaphylaxis, Japan, Acute urticaria, allergen

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References

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Honda Y, Yamamoto M, Nakajima K, Chinuki Y, Sano H. Delayed Anaphylaxis after Eating Beef Lilkely Due to IgE Antibody Specific for Galactose-α-1,3-galactose. Nishinihonhifu (Japanese) 2015; 77: 453-455.

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Nakamura E, Toyoda Y, Yatagai T, Majima Y, Hashizume H. A case of alpha-Gal syndrome presenting anaphylactic shock after ingestion of flounder roe. The 119th Shizuoka Regional Dermatological Meeting; 2017. Shizuoka.

Chinuki Y, Takahashi H, Morita E. IgE antibodies to galactose-α-1,3-galactose, an Epitope of red meat allergen, cross-react with a novel flounder roe allergen. J Investig Allergol Clin Immunol, 2022; 32: 324-326.

https://doi.org/10.18176/jiaci.0754 DOI: https://doi.org/10.18176/jiaci.0754

Seko A, Kitajima K, Iwasaki M, Inoue S, Inoue Y. Structural studies of fertilization-associated carbohydrate-rich glycoproteins (hyosophorin) isolated from the fertilized and unfertilized eggs of flounder, paralichthys olivaceus. Presence of a novel penta-antennary N-linked glycan chain in the tandem repeating glycopeptide unit of hyosophorin. J Biol Chem, 1989; 264: 15922-15929.

https://doi.org/10.1016/S0021-9258(18)71567-6 DOI: https://doi.org/10.1016/S0021-9258(18)71567-6

Iglesia EGA, Kwan M, Virkud YV, Iweala OI. Management of food allergies and food-related anaphylaxis. JAMA, 2024; 331: 510-521.

https://doi.org/10.1001/jama.2023.26857 DOI: https://doi.org/10.1001/jama.2023.26857

Published

2025-02-12

How to Cite

Hashizume, H., Matsuura, A., Ishikawa, Y., & Hata, A. (2025). Flounder Roe Triggering α-Gal Syndrome: Hyosophorin as a Possible Allergen. Acta Dermato-Venereologica, 105, adv42664. https://doi.org/10.2340/actadv.v105.42664

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