Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study
DOI:
https://doi.org/10.2340/actadv.v102.4451Keywords:
basal cell carcinoma, non-melanoma skin cancer, epidemiologyAbstract
Evidence of the association between a personal history of basal cell carcinoma and the risk of non-cutaneous malignancies is conflicting. The aim of this study was to retrospectively clarify the risk of non-cutaneous cancers in individuals with basal cell carcinoma using nationwide Finnish registry data for 96,304 patients and 394,503 randomly selected population controls. In this study, individuals with basal cell carcinoma have an increased risk of other cancers (odds ratio (OR) 1.38; 95% confidence interval (95% CI) 1.36–1.40). The risk was most prominent for lip cancer (OR 5.29; 95% CI 4.50–6.21), mycosis fungoides (OR 3.13; 95% CI 2.31–4.23) and soft tissue cancers (OR 2.77; 95% CI 2.43–3.16). In age-adjusted model, men had higher risk of cancers overall compared with women (p < 0.05). In conclusion, the study found increased overall cancer risk among patients with basal cell carcinoma compared with randomly selected population controls.
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Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012; 166: 1069-1080.
https://doi.org/10.1111/j.1365-2133.2012.10830.x DOI: https://doi.org/10.1111/j.1365-2133.2012.10830.x
Adalsteinsson JA, Ratner D, Olafsdottir E, Grant-Kels J, Ungar J, Silverberg JI, et al. Basal cell carcinoma: an emerging epidemic in women in Iceland. Br J Dermatol 2020; 183: 847-856.
https://doi.org/10.1111/bjd.18937 DOI: https://doi.org/10.1111/bjd.18937
Flohil SC, Seubring I, van Rossum MM, Coebergh JW, de Vries E, Nijsten T. Trends in Basal cell carcinoma incidence rates: a 37-year Dutch observational study J Invest Dermatol 2013; 133: 913-918.
https://doi.org/10.1038/jid.2012.431 DOI: https://doi.org/10.1038/jid.2012.431
Birch-Johansen F, Jensen A, Mortensen L, Olesen AB, Kjaer SK. Trends in the incidence of nonmelanoma skin cancer in Denmark 1978-2007: Rapid incidence increase among young Danish women. Int J Cancer 2010; 127: 2190-2198.
https://doi.org/10.1002/ijc.25411 DOI: https://doi.org/10.1002/ijc.25411
Kricker A, Armstrong BK, English DR, Heenan PJ. Does intermittent sun exposure cause basal cell carcinoma? a case-control study in Western Australia. Int J Cancer 1995; 60: 489-494.
https://doi.org/10.1002/ijc.2910600411 DOI: https://doi.org/10.1002/ijc.2910600411
Armstrong BK, Kricker A. The epidemiology of UV induced skin cancer. J Photochem Photobiol B 2001; 63: 8-18.
https://doi.org/10.1016/S1011-1344(01)00198-1 DOI: https://doi.org/10.1016/S1011-1344(01)00198-1
Grant WB. Review of recent advances in understanding the role of vitamin D in reducing cancer risk: breast, colorectal, prostate, and overall cancer. Anticancer Res 2020; 40: 491-499.
https://doi.org/10.21873/anticanres.13977 DOI: https://doi.org/10.21873/anticanres.13977
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, et al. The role of vitamin D in cancer prevention. Am J Public Health 2006; 96: 252-261.
https://doi.org/10.2105/AJPH.2004.045260 DOI: https://doi.org/10.2105/AJPH.2004.045260
Soerjomataram I, Louwman WJ, Lemmens VE, Coebergh JW, de Vries E. Are patients with skin cancer at lower risk of developing colorectal or breast cancer? Am J Epidemiol 2008; 167: 1421-1429.
https://doi.org/10.1093/aje/kwn077 DOI: https://doi.org/10.1093/aje/kwn077
de Vries E, Soerjomataram I, Houterman S, Louwman MW, Coebergh JW. Decreased risk of prostate cancer after skin cancer diagnosis: a protective role of ultraviolet radiation? Am J Epidemiol 2007; 165: 966-972.
https://doi.org/10.1093/aje/kwk084 DOI: https://doi.org/10.1093/aje/kwk084
Bower CP, Lear JT, Bygrave S, Etherington D, Harvey I, Archer CB. Basal cell carcinoma and risk of subsequent malignancies: a cancer registry-based study in southwest England. J Am Acad Dermatol 2000; 42: 988-991.
https://doi.org/10.1067/mjd.2000.103978 DOI: https://doi.org/10.1067/mjd.2000.103978
Friedman GD, Tekawa IS. Association of basal cell skin cancers with other cancers (United States). Cancer Causes Control 2000; 11: 891-987.
https://doi.org/10.1023/A:1026591016153 DOI: https://doi.org/10.1023/A:1026591016153
Lindelof B, Krynitz B, Ayoubi S, Martschin C, Wiegleb- Edström D, Wiklund K. Previous extensive sun exposure and subsequent vitamin D production in patients with basal cell carcinoma of the skin, has no protective effect on internal cancers. Eur J Cancer 2012; 48: 1154-1158.
https://doi.org/10.1016/j.ejca.2011.06.049 DOI: https://doi.org/10.1016/j.ejca.2011.06.049
Nugent Z, Demers AA, Wiseman MC, Mihalcioiu C, Kliewer E v. Risk of second primary cancer and death following a diagnosis of nonmelanoma skin cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 2584-2590.
https://doi.org/10.1158/1055-9965.EPI-05-0379 DOI: https://doi.org/10.1158/1055-9965.EPI-05-0379
Krilaviciute A, Vincerzevskiene I, Smailyte G. Basal cell skin cancer and the risk of second primary cancers: a cancer registry-based study in Lithuania. Ann Epidemiol 2016; 26:511-514.
https://doi.org/10.1016/j.annepidem.2016.05.003 DOI: https://doi.org/10.1016/j.annepidem.2016.05.003
Milan T, Pukkala E, Verkasalo PK, Kaprio J, Jansen CT, Koskenvuo M, et al. Subsequent primary cancers after basal-cell carcinoma: a nationwide study in Finland from 1953 to 1995. Int J Cancer 2000; 87: 283-288.
https://doi.org/10.1002/1097-0215(20000715)87:2<283::AID-IJC21>3.0.CO;2-I DOI: https://doi.org/10.1002/1097-0215(20000715)87:2<283::AID-IJC21>3.0.CO;2-I
Song F, Qureshi AA, Giovannucci EL, Fuchs CS, Chen WY, Stampfer MJ, et al. Risk of a second primary cancer after non-melanoma skin cancer in white men and women: a prospective cohort study. PLoS Med 2013; 10: e1001433.
https://doi.org/10.1371/journal.pmed.1001433 DOI: https://doi.org/10.1371/journal.pmed.1001433
Chen J, Ruczinski I, Jorgensen TJ, Yenokyan G, Yao Y, Alani R, et al. Nonmelanoma skin cancer and risk for subsequent malignancy. J Natl Cancer Inst 2008; 100: 1215-1222.
https://doi.org/10.1093/jnci/djn260 DOI: https://doi.org/10.1093/jnci/djn260
Lindelöf B, Sigurgeirsson B, Wallberg P, Eklund G. Occurrence of other malignancies in 1973 patients with basal cell carcinoma. J Am Acad Dermatol 1991; 25: 245-248.
https://doi.org/10.1016/0190-9622(91)70189-9 DOI: https://doi.org/10.1016/0190-9622(91)70189-9
Wheless L, Black J, Alberg AJ. Nonmelanoma skin cancer and the risk of second primary cancers: a systematic review. Cancer Epidemiol Biomarkers Prev 2010; 19: 1686-1695.
https://doi.org/10.1158/1055-9965.EPI-10-0243 DOI: https://doi.org/10.1158/1055-9965.EPI-10-0243
Frisch M, Hjalgrim H, Olsen JH, Melbye M. Risk for subsequent cancer after diagnosis of basal-cell carcinoma: a population-based, epidemiologic study. Ann Intern Med 1996; 125: 815-821.
https://doi.org/10.7326/0003-4819-125-10-199611150-00005 DOI: https://doi.org/10.7326/0003-4819-125-10-199611150-00005
Levi F, la Vecchia C, Te VC, Randimbison L, Erler G. Incidence of invasive cancers following basal cell skin cancer. Am J Epidemiol 1998; 147: 722-726.
https://doi.org/10.1093/oxfordjournals.aje.a009516 DOI: https://doi.org/10.1093/oxfordjournals.aje.a009516
Nikolaou V, Stratigos AJ, Tsao H. Hereditary nonmelanoma skin cancer. Semin Cutan Med Surg 2012; 31: 204-210.
https://doi.org/10.1016/j.sder.2012.08.005 DOI: https://doi.org/10.1016/j.sder.2012.08.005
Jaju PD, Ransohoff KJ, Tang JY, Sarin KY. Familial skin cancer syndromes: increased risk of nonmelanotic skin cancers and extracutaneous tumors. J Am Acad Dermatol 2016; 74: 434-437.
https://doi.org/10.1016/j.jaad.2015.08.073 DOI: https://doi.org/10.1016/j.jaad.2015.08.073
Cantwell MM, Murray LJ, Catney D, Donnelly D, Autier P, Boniol M, et al. Second primary cancers in patients with skin cancer: a population-based study in Northern Ireland. Br J Cancer 2009; 100: 174-177.
https://doi.org/10.1038/sj.bjc.6604842 DOI: https://doi.org/10.1038/sj.bjc.6604842
Tuohimaa P, Pukkala E, Scelo G, Olsen JH, Brewster DH, Hemminki K, et al. Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation. Eur J Cancer 2007; 43: 1701-1712.
https://doi.org/10.1016/j.ejca.2007.04.018 DOI: https://doi.org/10.1016/j.ejca.2007.04.018
Moore SR, Johnson NW, Pierce AM, Wilson DF. The epidemiology of lip cancer: a review of global incidence and aetiology. Oral Dis 1999; 5: 185-195.
https://doi.org/10.1111/j.1601-0825.1999.tb00300.x DOI: https://doi.org/10.1111/j.1601-0825.1999.tb00300.x
Väkevä L, Pukkala E, Ranki A. Increased risk of secondary cancers in patients with primary cutaneous t cell lymphoma. J Invest Dermatol 2000; 115: 62-65.
https://doi.org/10.1046/j.1523-1747.2000.00011.x DOI: https://doi.org/10.1046/j.1523-1747.2000.00011.x
Goyal A, O'Leary D, Goyal K, Rubin N, Bohjanen K, Hordinsky M, et al. Increased risk of second primary malignancies in patients with mycosis fungoides: a single-center cohort study. J Am Acad Dermatol 2020; 82: 736-738.
https://doi.org/10.1016/j.jaad.2019.06.037 DOI: https://doi.org/10.1016/j.jaad.2019.06.037
Kantor AF, Curtis RE, Vonderheid EC, van Scott EJ, Fraumeni Jr JF. Risk of second malignancy after cutaneous T-cell lymphoma cancer 1989; 63: 1612-1615.
https://doi.org/10.1002/1097-0142(19890415)63:8<1612::AID-CNCR2820630828>3.0.CO;2-C DOI: https://doi.org/10.1002/1097-0142(19890415)63:8<1612::AID-CNCR2820630828>3.0.CO;2-C
Huang KP, Weinstock MA, Clarke CA, Mcmillan A, Hoppe RT, Kim YH. Second lymphomas and other malignant neoplasms in patients with mycosis fungoides and Sézary syndrome evidence from population-based and clinical cohorts. Arch Dermatol 2007; 143: 45-50.
https://doi.org/10.1001/archderm.143.1.45 DOI: https://doi.org/10.1001/archderm.143.1.45
Hodak E, Lessin S, Friedland R, Freud T, David M, Pavlovsky L, et al. New insights into associated co-morbidities in patients with cutaneous T-cell lymphoma (mycosis fungoides). Acta Derm Venereol 2013; 93: 451-455.
https://doi.org/10.2340/00015555-1496 DOI: https://doi.org/10.2340/00015555-1496
Pitkäniemi J, Malila N, Virtanen A, Degerlund H, Heikkinen S, Seppä K. Cancer in Finland 2018. Cancer Society of Finland Publication No. 94, Helsinki 2020.
Larsen IK, Myklebust TÅ, Babigumira R, Vinberg E, Møller B, Ursin G. Education, income and risk of cancer: results from a Norwegian registry-based study. Acta Oncol 2020; 59: 1300-1307.
https://doi.org/10.1080/0284186X.2020.1817548 DOI: https://doi.org/10.1080/0284186X.2020.1817548
Steding-Jessen M, Birch-Johansen F, Jensen A, Schüz J, Kjær SK, Dalton SO. Socioeconomic status and non-melanoma skin cancer: a nationwide cohort study of incidence and survival in Denmark. Cancer Epidemiol 2010; 34: 689-695.
https://doi.org/10.1016/j.canep.2010.06.011 DOI: https://doi.org/10.1016/j.canep.2010.06.011
Karagas MR, Greenberg ER, Mott LA, Baron JA, Ernster VL. Occurrence of other cancers among patients with prior basal cell and squamous cell skin cancer. Cancer Epidemiol Biomarkers Prev 1998; 7: 157-161.
Jensen AO, Lamberg AL, Jacobsen JB, Braae Olesen A, Sorensen HT. Non-melanoma skin cancer and ten-year all-cause mortality: a population-based cohort study. Acta Derm Venereol 2010; 90: 362-367.
https://doi.org/10.2340/00015555-0899 DOI: https://doi.org/10.2340/00015555-0899
Jensen AO, Bautz A, Olesen AB, Karagas MR, Sorensen HT, Friis S. Mortality in Danish patients with nonmelanoma skin cancer, 1978-2001. Br J Dermatol 2008; 159: 419-425.
https://doi.org/10.1111/j.1365-2133.2008.08698.x DOI: https://doi.org/10.1111/j.1365-2133.2008.08698.x
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