Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch


  • Leigh A. Nattkemper Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami, Miami, FL, USA
  • Zoe M. Lipman Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami, Miami, FL, USA
  • Giuseppe Ingrasci Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami, Miami, FL, USA
  • Claudia Maldonado Departamento de Dermatología, Hospital Luis Vernaza, Guayaquil, Ecuador
  • Juan Carlos Garces Departamento de Dermatología, Hospital Luis Vernaza, Guayaquil, Ecuador
  • Enrique Loayza
  • Gil Yosipovitch Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami, Miami, FL, USA



psoriasis, pruritus, scalp psoriasis


Scalp psoriatic itch is a common, bothersome, yet understudied, condition with numerous associated treatment challenges. The aim of this study was to enhance our understanding of the pathophysiology of scalp psoriatic itch. Immunohistochemical analysis of known neuroimmune mediators of pruritus was conducted using scalp biopsies from 27 Hispanic psoriatic patients. Patients were categorized into mild/moderate or severe itch groups according to their itch intensity rating of scalp itch. Protease activated receptor (PAR2), substance P, transient receptor potential (TRP)V3, TRPM8 and interleukin-23 expression all correlated  significantly with itch intensity. The pathophysiology of scalp psoriasis is largely non-histaminergic, mediated by PAR2, interleukin-23, transient receptor potential channels, and substance P.


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How to Cite

Nattkemper, L. A., Lipman, Z. M., Ingrasci, G., Maldonado, C., Garces, J. C., Loayza, E., & Yosipovitch, G. (2023). Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch. Acta Dermato-Venereologica, 103, adv4463.

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