Impact of Atopic Dermatitis on Patients and their Partners

Authors

  • Laurent Misery Department of Dermatology, Brest University Hospital, Brest, France
  • Julien Seneschal Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin disorders, Hospital Saint-André, Bordeaux, France.
  • Florence Corgibet Dermatologist, private practice, Dijon, France
  • Bruno Halioua Dermatologist, private practice, Paris, France
  • Adrien Marquié Data anlayst, Paris, France
  • Stéphanie Merhand Association Francaise de l’Eczema
  • Gaelle Le Fur Sociologist, Paris, France
  • Delphine Staumont -Salle Department of Dermatology, Lille University Hospital, Lille, France
  • Christina Bergqvist Department of dermatology, Hôpital Henri Mondor, APHP, Creteil, France
  • Charles Taieb Patient Priority Department, European Market Maintenance Assessment, FR-94120 Fontenay sous Bois, France
  • Khaled Ezzedine EA 7379 EpidermE, Université Paris-Est Créteil (UPEC), Créteil, France
  • Marie-Aleth Richard Department of dermatology, Aix-Marseille University, La Timone university hospital, Marseille, France, CEReSS-EA 3279, health services and quality of life research centre, Aix Marseille University, dermatology department, La Timone university hospital APHM, 13385, Marseille, France.

DOI:

https://doi.org/10.2340/actadv.v103.5285

Keywords:

atopic dermatitis, partners, burden, quality-of-life, sleep

Abstract

Atopic dermatitis is a chronic, relapsing and inflammatory skin disease. The impact of atopic dermatitis on the partners living with patients has been poorly investigated. The objective of this study was to evaluate the impact of atopic dermatitis in the daily lives of adult patients and to assess the burden of the disease on their partners. A population-based study was conducted on a representative sample of the general population of French adults aged 18 years of age using stratified, proportional sampling with a replacement design. Data were collected on 1,266 atopic dermatitis patient-partner dyads (mean age of patients 41.6 years, 723 (57.1%) women). The mean age of partners was 41.8 years. Patient burden, measured by the Atopic Dermatitis Burden Scale for Adults (ABS-A) score, was closely related to the objective atopic dermatitis severity: the mean score in the mild group (29.5) was significantly lower than in the moderate (43.9) and severe groups (48.6) (p < 0.0001). Partner burden, measured by the EczemaPartner score, was highly related to atopic dermatitis severity (p < 0.0001). Daytime sleepiness, measured by the Epworth Sleepiness Scale, showed a mean score of 9.24 in patients and 9.01 in their partners, indicating impaired sleep. Atopic dermatitis was found to decrease sexual desire in 39% and 26% of partners and patients respectively.

Downloads

Download data is not yet available.

References

Richard MA, Corgibet F, Beylot-Barry M, Barbaud A, Bodemer C, Chaussade V, et al. Sex- and age-adjusted prevalence estimates of five chronic inflammatory skin diseases in France: results of the "OBJECTIFS PEAU" study. J Eur Acad Dermatol Venereol 2018; 32: 1967-1971.

https://doi.org/10.1111/jdv.14959 DOI: https://doi.org/10.1111/jdv.14959

Rönmark EP, Ekerljung L, Lötvall J, Wennergren G, Rönmark E, Torén K, et al. Eczema among adults: prevalence, risk factors and relation to airway diseases. Results from a large-scale population survey in Sweden. Br J Dermatol 2012; 166: 1301-1308.

https://doi.org/10.1111/j.1365-2133.2012.10904.x DOI: https://doi.org/10.1111/j.1365-2133.2012.10904.x

Vinding GR, Zarchi K, Ibler KS, Miller IM, Ellervik C, Jemec GBE. Is adult atopic eczema more common than we think? A population-based study in Danish adults. Acta Derm Venereol 2014; 94: 480-482.

https://doi.org/10.2340/00015555-1761 DOI: https://doi.org/10.2340/00015555-1761

Silverberg JI, Gelfand JM, Margolis DJ, Boguniewicz M, Fonacier L, Grayson MH, et al. Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study. Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol 2018; 121: 340-347.

https://doi.org/10.1016/j.anai.2018.07.006 DOI: https://doi.org/10.1016/j.anai.2018.07.006

Eckert L, Gupta S, Amand C, Gadkari A, Mahajan P, Gelfand JM. Impact of atopic dermatitis on health-related quality of life and productivity in adults in the United States: an analysis using the National Health and Wellness Survey. J Am Acad Dermatol 2017; 77: 274-279.e3.

https://doi.org/10.1016/j.jaad.2017.04.019 DOI: https://doi.org/10.1016/j.jaad.2017.04.019

Ramirez FD, Chen S, Langan SM, Prather AA, McCulloch CE, Kidd SA, et al. Association of atopic dermatitis with sleep quality in children. JAMA Pediatr 2019; 173: e190025.

https://doi.org/10.1001/jamapediatrics.2019.0025 DOI: https://doi.org/10.1001/jamapediatrics.2019.0025

Golics CJ, Basra MKA, Finlay AY, Salek S. The impact of disease on family members: a critical aspect of medical care. J R Soc Med 2013; 106: 399-407.

https://doi.org/10.1177/0141076812472616 DOI: https://doi.org/10.1177/0141076812472616

Barbarot S, Silverberg JI, Gadkari A, Simpson EL, Weidinger S, Mina-Osorio P, et al. The family impact of atopic dermatitis in the pediatric population: results from an international cross-sectional study. J Pediatr 2022; 246: 220-226.e5.

https://doi.org/10.1016/j.jpeds.2022.04.027 DOI: https://doi.org/10.1016/j.jpeds.2022.04.027

Basra MKA, Finlay AY. The family impact of skin diseases: the greater patient concept. Br J Dermatol 2007; 156: 929-937.

https://doi.org/10.1111/j.1365-2133.2007.07794.x DOI: https://doi.org/10.1111/j.1365-2133.2007.07794.x

Ali F, Vyas J, Finlay AY. Counting the burden: atopic dermatitis and health-related quality of life. Acta Derm Venereol 2020; 100: adv00161.

https://doi.org/10.2340/00015555-3511 DOI: https://doi.org/10.2340/00015555-3511

Arima K, Gupta S, Gadkari A, Hiragun T, Kono T, Katayama I, et al. Burden of atopic dermatitis in Japanese adults: analysis of data from the 2013 National Health and Wellness Survey. J Dermatol 2018; 45: 390-396.

https://doi.org/10.1111/1346-8138.14218 DOI: https://doi.org/10.1111/1346-8138.14218

Halioua B, Maccari F, Fougerousse AC, Parier J, Reguiai Z, Taieb C, et al. Impact of patient psoriasis on partner quality of life, sexuality and empathy feelings: a study in 183 couples. J Eur Acad Dermatol Venereol 2020; 34: 2044-2050.

https://doi.org/10.1111/jdv.16270 DOI: https://doi.org/10.1111/jdv.16270

Misery L, Finlay AY, Martin N, Boussetta S, Nguyen C, Myon E, et al. Atopic dermatitis: impact on the quality of life of patients and their partners. Dermatol Basel Switz 2007; 215: 123-129.

https://doi.org/10.1159/000104263 DOI: https://doi.org/10.1159/000104263

Misery L, Seneschal J, Reguiai Z, Merhand S, Héas S, Huet F, et al. The impact of atopic dermatitis on sexual health. J Eur Acad Dermatol Venereol 2019; 33: 428-432.

https://doi.org/10.1111/jdv.15223 DOI: https://doi.org/10.1111/jdv.15223

Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. The burden of atopic dermatitis: summary of a report for the National Eczema Association. J Invest Dermatol 2017; 137: 26-30.

https://doi.org/10.1016/j.jid.2016.07.012 DOI: https://doi.org/10.1016/j.jid.2016.07.012

Linares-Gonzalez L, Lozano-Lozano I, Gutierrez-Rojas L, Lozano-Lozano M, Rodenas-Herranz T, Ruiz-Villaverde R. Sexual dysfunction and atopic dermatitis: a systematic review. Life Basel Switz 2021; 11: 1314.

https://doi.org/10.3390/life11121314 DOI: https://doi.org/10.3390/life11121314

Ludwig CM, Fernandez JM, Hsiao JL, Shi VY. The interplay of atopic dermatitis and sexual health. Dermatitis 2020; 31: 303-308.

https://doi.org/10.1097/DER.0000000000000617 DOI: https://doi.org/10.1097/DER.0000000000000617

Charman CR, Venn AJ, Williams HC. The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients' perspective. Arch Dermatol 2004; 140: 1513-1519.

https://doi.org/10.1001/archderm.140.12.1513 DOI: https://doi.org/10.1001/archderm.140.12.1513

Charman CR, Venn AJ, Ravenscroft JC, Williams HC. Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods. Br J Dermatol 2013; 169: 1326-1332.

https://doi.org/10.1111/bjd.12590 DOI: https://doi.org/10.1111/bjd.12590

Taïeb A, Boralevi F, Seneschal J, Merhand S, Georgescu V, Taieb C, et al. Atopic Dermatitis Burden Scale for Adults: development and validation of a new assessment tool. Acta Derm Venereol 2015; 95: 700-705.

https://doi.org/10.2340/00015555-1945 DOI: https://doi.org/10.2340/00015555-1945

Shourick J, Taieb C, Seneschal J, Merhand S, Ezzedine K, Halioua B, et al. EczemaPartner - adapting a questionnaire to assess the impact of atopic dermatitis on partners of patients. J Eur Acad Dermatol Venereol 2022; 36: e192-193.

https://doi.org/10.1111/jdv.17726 DOI: https://doi.org/10.1111/jdv.17726

Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14: 540-545.

https://doi.org/10.1093/sleep/14.6.540 DOI: https://doi.org/10.1093/sleep/14.6.540

Andersen L, Nyeland ME, Nyberg F. Higher self-reported severity of atopic dermatitis in adults is associated with poorer self-reported health-related quality of life in France, Germany, the U.K. and the U.S.A. Br J Dermatol 2020; 182: 1176-1183.

https://doi.org/10.1111/bjd.18451 DOI: https://doi.org/10.1111/bjd.18451

Chiesa Fuxench ZC, Block JK, Boguniewicz M, Boyle J, Fonacier L, Gelfand JM, et al. Atopic Dermatitis in America Study: a cross-sectional study examining the prevalence and disease burden of atopic dermatitis in the US adult population. J Invest Dermatol 2019; 139: 583-590.

https://doi.org/10.1016/j.jid.2018.08.028 DOI: https://doi.org/10.1016/j.jid.2018.08.028

Mahe E, Shourick J, Mallet S, Abasq C, Bursztejn AC, Sampogna F, et al. Perceived clinical severity of atopic dermatitis in children: comparison between patients' and parents' evaluation. J Eur Acad Dermatol Venereol 2022; 36: e592-594

https://doi.org/10.1111/jdv.18083 DOI: https://doi.org/10.1111/jdv.18083

Bawany F, Northcott CA, Beck LA, Pigeon WR. Sleep disturbances and atopic dermatitis: relationships, methods for assessment, and therapies. J Allergy Clin Immunol Pract 2021; 9: 1488-1500.

https://doi.org/10.1016/j.jaip.2020.12.007 DOI: https://doi.org/10.1016/j.jaip.2020.12.007

Chang YS, Chou YT, Lee JH, Lee PL, Dai YS, Sun C, et al. Atopic dermatitis, melatonin, and sleep disturbance. Pediatrics 2014; 134: e397-405.

https://doi.org/10.1542/peds.2014-0376 DOI: https://doi.org/10.1542/peds.2014-0376

Silverberg JI, Chiesa-Fuxench Z, Margolis D, Boguniewicz M, Fonacier L, Grayson M, et al. Sleep disturbances in atopic dermatitis in US adults. Dermatitis 2022; 33: S104-113

https://doi.org/10.1097/DER.0000000000000731 DOI: https://doi.org/10.1097/DER.0000000000000731

Parish JM, Lyng PJ. Quality of life in bed partners of patients with obstructive sleep apnea or hypopnea after treatment with continuous positive airway pressure. Chest 2003; 124: 942-947.

https://doi.org/10.1378/chest.124.3.942 DOI: https://doi.org/10.1378/chest.124.3.942

Marklund H, Spångberg A, Edéll-Gustafsson U. Sleep and partner-specific quality of life in partners of men with lower urinary tract symptoms compared with partners of men from the general population. Scand J Urol 2015; 49: 321-328.

https://doi.org/10.3109/21681805.2014.990052 DOI: https://doi.org/10.3109/21681805.2014.990052

Strawbridge WJ, Shema SJ, Roberts RE. Impact of Spouses' sleep problems on partners. Sleep 2004; 27: 527-531.

https://doi.org/10.1093/sleep/27.3.527 DOI: https://doi.org/10.1093/sleep/27.3.527

Hua T, Silverberg JI. Atopic dermatitis in US adults: epidemiology, association with marital status, and atopy. Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol 2018; 121: 622-624.

https://doi.org/10.1016/j.anai.2018.07.019 DOI: https://doi.org/10.1016/j.anai.2018.07.019

Additional Files

Published

2023-06-26

How to Cite

Misery, L., Seneschal, J., Corgibet, F., Halioua, B., Marquié, A., Merhand, S., … Richard, M.-A. (2023). Impact of Atopic Dermatitis on Patients and their Partners. Acta Dermato-Venereologica, 103, adv5285. https://doi.org/10.2340/actadv.v103.5285

Issue

Section

Articles

Categories