Laser-mediated Photodynamic Therapy: An Alternative Treatment for Actinic Keratosis?

Authors

  • Janneke P.H.M. Kessels
  • Patty J. Nelemans
  • Klara Mosterd
  • Nicole W.J. Kelleners-Smeets
  • Gertruud A.M. Krekels
  • Judith U. Ostertag

DOI:

https://doi.org/10.2340/00015555-2278

Abstract

Photodynamic therapy (PDT) with light emitting diode (LED) illumination is a frequently used treatment modality for actinic keratosis (AK) with excellent cosmetic outcome. A major disadvantage, however, is the high pain score. Pulsed dye laser (PDL) illumination has been suggested, but the long-term efficacy of this treatment is unknown. In this split-face study we prospectively treated 61 patients with AK, with both LED-PDT and PDL-PDT. The mean change in the number of lesions between the end of follow-up and start of therapy was –4.25 (95% confidence interval (95% CI) –5.07; –3.43) for LED-PDT and –3.88 (95% CI –4,76; –2.99) for PDL-PDT, with a non-significant difference (p=0.258) of –0.46 (95% CI –1.28; 0.35). The percentage decrease from baseline in the total number of AK was 55.8% and 47.8%, respectively, at 12-month follow-up. Visual analogue scale pain score was lower after PDL (mean 2.64) compared with LED illumination (mean 6.47). These findings indicate that PDL-PDT is an effective alternative illumination source fo

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Published

2015-11-16

How to Cite

Kessels, J. P., Nelemans, P. J., Mosterd, K., Kelleners-Smeets, N. W., Krekels, G. A., & Ostertag, J. U. (2015). Laser-mediated Photodynamic Therapy: An Alternative Treatment for Actinic Keratosis?. Acta Dermato-Venereologica, 96(3), 351–354. https://doi.org/10.2340/00015555-2278

Issue

Vol. 96 No. 3 (2016)

Section

Articles

License

Copyright (c) 2015 Janneke P.H.M. Kessels, Patty J. Nelemans, Klara Mosterd, Nicole W.J. Kelleners-Smeets, Gertruud A.M. Krekels, Judith U. Ostertag

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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