Expert Recommendations on Facilitating Personalized Approaches to Long-term Management of Actinic Keratosis: The Personalizing Actinic Keratosis Treatment (PAKT) Project

Authors

  • Colin Morton Department of Dermatology, NHS Forth Valley, Stirling, United Kingdom
  • Samira Baharlou Department of Dermatology, Skin Immunology & Immune Tolerance (SKIN) Research Group, Vrije Universiteit Brussel, Brussels, Belgium; Universitair Ziekenhuis Brussel, Brussels, Belgium
  • Nicole Basset-Seguin Université de Paris, Paris, France; Hôpital Saint-Louis, Paris, France
  • Piergiacomo Calzavara-Pinton Dermatology Department, University of Brescia, Brescia, Italy
  • Thomas Dirschka CentroDerm Clinic, Wuppertal, Germany
  • Yolanda Gilaberte Department of Dermatology, Miguel Servet University Hospital, IIS Aragón, Zaragoza, Spain
  • Merete Haedersdal Department of Dermatology, Bispebjerg and Frederiksberg Hospitals, Copenhagen University Hospital, Copenhagen
  • Günther Hofbauer University Hospital Zürich, University of Zürich, Zürich, Switzerland
  • Sheetal Sapra Oakville Trafalgar Memorial Hospital, Oakville, Canada; Institution of Cosmetic and Laser Surgery, Oakville, Canada
  • Rick Waalboer-Spuij Erasmus MC Cancer Institute, Rotterdam, The Netherlands
  • Leona Yip Skin Partners, Brisbane, Australia
  • Rolf-Markus Szeimies Department of Dermatology & Allergology, Klinikum Vest GmbH Academic Teaching Hospital, Recklinghausen, Germany

DOI:

https://doi.org/10.2340/actadv.v103.6229

Keywords:

actinic keratosis, consensus, Delphi study, squamous cell carcinoma, surveys and questionnaires, skin cancer

Abstract

Actinic keratoses are pre-malignant skin lesions that require personalized care, a lack of which may result in poor treatment adherence and suboptimal outcomes. Current guidance on personalizing care is limited, notably in terms of tailoring treatment to individual patient priorities and goals and supporting shared decision-making between healthcare professionals and patients. The aim of the Personalizing Actinic Keratosis Treatment panel, comprised of 12 dermatologists, was to identify current unmet needs in care and, using a modified Delphi approach, develop recommendations to support personalized, long-term management of actinic keratoses lesions. Panellists generated recommendations by voting on consensus statements. Voting was blinded and consensus was defined as ≥ 75% voting ’agree’ or ’strongly agree’. Statements that reached consensus were used to develop a clinical tool, of which, the goal was to improve understanding of disease chronicity, and the need for long-term, repeated treatment cycles. The tool highlights key decision stages across the patient journey and captures the panellist’s ratings of treatment options for attributes prioritized by patients. The expert recommendations and the clinical tool can be used to facilitate patient-centric management of actinic keratoses in daily practice, encompassing patient priorities and goals to set realistic treatment expectations and improve care outcomes.

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Published

2023-06-08

How to Cite

Morton, C. ., Baharlou, S. ., Basset-Seguin, N., Calzavara-Pinton, P., Dirschka, T., Gilaberte, Y., Haedersdal, M., Hofbauer, G., Sapra, S., Waalboer-Spuij, R., Yip, L., & Szeimies, R.-M. (2023). Expert Recommendations on Facilitating Personalized Approaches to Long-term Management of Actinic Keratosis: The Personalizing Actinic Keratosis Treatment (PAKT) Project. Acta Dermato-Venereologica, 103, adv6229. https://doi.org/10.2340/actadv.v103.6229