Clinical Significance of Anti-desmoglein-1 and -3 Circulating Autoantibodies in Pemphigus Patients Measured by Area Index and Intensity Score

Authors

  • Aikaterini Patsatsi
  • Aikaterini Kyriakou
  • Anastasia Giannakou
  • Aikaterini Pavlitou-Tsiontsi
  • Alexandros Lambropoulos
  • Dimitrios Sotiriadis

DOI:

https://doi.org/10.2340/00015555-1666

Keywords:

anti-DSG-1, anti-DSG-3, pemphigus, PDAI, ABSIS.

Abstract

Detection of anti-desmoglein-1 (anti-DSG-1) and anti-DSG-3 autoantibodies is widely used in the diagnosis of pemphigus. Two validated scoring systems, Pemphigus Disease Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), are used for the evaluation of clinical severity. The aim of this cross-sectional study was to interpret the titres of pemphigus autoantibodies in correlation with either total or location-dependent PDAI scores and ABSIS. A total of 35 pemphigus patients were selected and evaluated at 3 time points. Total PDAI and ABSIS seemed useful in pemphigus with cutaneous lesions or in the mucocutaneous form, while location-dependent PDAI and ABSIS scores were useful in the mucosal form. Anti-DSG-1 autoantibodies titres better showed the disease extent in pemphigus with cutaneous only or with mucocutaneous lesions. Anti-DSG-3 autoantibodies titres did not correlate to disease activity.

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Published

2013-08-06

How to Cite

Patsatsi, A., Kyriakou, A., Giannakou, A., Pavlitou-Tsiontsi, A., Lambropoulos, A., & Sotiriadis, D. (2013). Clinical Significance of Anti-desmoglein-1 and -3 Circulating Autoantibodies in Pemphigus Patients Measured by Area Index and Intensity Score. Acta Dermato-Venereologica, 94(2), 203–206. https://doi.org/10.2340/00015555-1666

Issue

Vol. 94 No. 2 (2014)

Section

Articles

License

Copyright (c) 2013 Aikaterini Patsatsi, Aikaterini Kyriakou, Anastasia Giannakou, Aikaterini Pavlitou-Tsiontsi, Alexandros Lambropoulos, Dimitrios Sotiriadis

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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