Interaction between 8-methoxypsoralen and phenytoin. Consequence for PUVA therapy
DOI:
https://doi.org/10.2340/0001555565553555Abstract
A patient with epilepsy and psoriasis in phenytoin therapy was treated with PUVA with no effect at all. The PUVA treatment failure was demonstrated as being due to abnormally low serum levels of 8-methoxypsoralen (8-MOP) during phenytoin therapy, while normal serum levels of 8-MOP were observed after phenytoin was discontinued. The effect is probably due to an induction of the hepatic enzyme system by phenytoin, leading to an increased metabolism of 8-MOP. Other drugs with hepatic enzyme inducing properties might possibly also interfere with psoralen metabolism with further consequences for PUVA therapy.Downloads
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Published
1985-11-01
How to Cite
Staberg, B., & Hueg, B. (1985). Interaction between 8-methoxypsoralen and phenytoin. Consequence for PUVA therapy. Acta Dermato-Venereologica, 65(6), 553–555. https://doi.org/10.2340/0001555565553555
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Copyright (c) 1985 Acta Dermato-VenereologicaAll digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
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