Proliferative responses of fibroblasts from psoriatic and normal skin to clobetasol propionate
DOI:
https://doi.org/10.2340/0001555563393396Abstract
The proliferation of fibroblasts cultured from psoriatic and normal skin was compared following addition of clobetasol propionate to the culture medium. Proliferation was stimulated at 0.1 microgram/ml and progressively inhibited at 1-10 micrograms/ml. A differential sensitivity to the drug was demonstrated: the fibroblasts from involved psoriatic skin were more stimulated than normal fibroblasts at 0.1 microgram/ml and then more inhibited at 10 micrograms/ml. The fibroblasts from uninvolved psoriatic skin displayed intermediate responses. There was some cytotoxicity in cultures of the psoriatic cells at 10 micrograms/ml. The results demonstrate a further abnormality of fibroblasts from psoriatic skin.Downloads
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