Guselkumab Treatment Outcomes and Persistence in a Nationwide Real-world Cohort of Patients with Plaque Psoriasis

Authors

  • Tarja Mälkönen Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland
  • Pauliina Nuutinen
  • Taru Hallinen
  • Erkki Soini
  • Riikka Nissinen
  • Christina Wennerstöm
  • Tapio Rantanen
  • Johanna H. Hagman
  • Rauno Harvima
  • Johanna Höök-Nikanne
  • Tiina Ilves
  • Päivi Lintu
  • Ken Malanin
  • Iina Soramäki
  • Kaisa Tasanen
  • Arja Teho
  • Katja Vähävihu
  • Sari Itälinna
  • Pekka Leinonen
  • Piia Sarajärvi
  • Laura Huilaja
  • Rafael Pasternack

DOI:

https://doi.org/10.2340/actadv.v101.910

Keywords:

psoriasis, guselkumab, treatment outcome, real-world, persistence

Abstract

Guselkumab treatment outcomes and persistence were assessed in a real-world cohort of Finnish patients with difficult-to-treat plaque psoriasis over a median follow-up of 1 year. Data on 181 patients who initiated guselkumab at the 15 study centres were collected retrospectively from the patient charts. Prior exposure to biologic therapies was common, with 56% and 35% having used at least 1 and 2 biologics, respectively. Median guselkumab treatment duration was 11 months with 21 patients (12%) discontinuing treatment during follow-up. Of 85 patients with a follow-up duration of at least 1 year, 73 (86%) were still on guselkumab at 1 year. Significant improvements during follow-up were seen in the absolute Psoriasis Area and Severity Index (PASI) scores with 32 patients (80%) having absolute PASI ≤ 2 after a 9–14-month treatment. Guselkumab treatment was effective and treatment persistence was high in the nationwide Finnish real-life setting.

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References

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Additional Files

Published

2022-01-18

How to Cite

Mälkönen, T., Nuutinen, P., Hallinen, T., Soini, E., Nissinen, R., Wennerstöm, C., Rantanen, T., Hagman, J. H., Harvima, R., Höök-Nikanne, J., Ilves, T., Lintu, P., Malanin, K., Soramäki, I., Tasanen, K., Teho, A., Vähävihu, K., Itälinna, S., Leinonen, P., Sarajärvi, P., Huilaja, L., & Pasternack, R. (2022). Guselkumab Treatment Outcomes and Persistence in a Nationwide Real-world Cohort of Patients with Plaque Psoriasis. Acta Dermato-Venereologica, 102, adv00631. https://doi.org/10.2340/actadv.v101.910

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