Chronic Prurigo of Nodular Type: A Review

Authors

  • Claudia Zeidler Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Str. 58, DE-48149 Münster, Germany
  • Athanasios Tsianakas Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Str. 58, DE-48149 Münster, Germany
  • Manuel Pereira Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Str. 58, DE-48149 Münster, Germany
  • Hartmut Ständer Dermatological Practice, Bad Bentheim, Germany; Department of Dermatology, Klinikum Dortmund GmbH, Dortmund, Germany
  • Gil Yosipovitch
  • Sonja Ständer Center for Chronic Pruritus, University Hospital Münster, Von-Esmarch-Str. 58, DE-48149 Münster, Germany

DOI:

https://doi.org/10.2340/00015555-2774

Keywords:

itch, pruritus, chronic scratch lesions, prurigo nodularis, Hyde’s prurigo, interleukin-31, neurokinin-1

Abstract

Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remains unclear. Current state-of-the-art therapy for PN consists of topical steroids, capsaicin, calcineurin inhibitors, ultraviolet (UV) therapy, systemic administration of gabapentinoids, μ-opioid receptor antagonists, antidepressants or immunosuppressants. Novel treatment concepts, such as inhibitors of neurokinin-1, opioid and interleukin-31 receptors, have been developed and are currently being clinically tested.

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Published

2018-01-31

How to Cite

Zeidler, C., Tsianakas, A., Pereira, M., Ständer, H., Yosipovitch, G., & Ständer, S. (2018). Chronic Prurigo of Nodular Type: A Review. Acta Dermato-Venereologica, 98(2), 173–179. https://doi.org/10.2340/00015555-2774

Issue

Vol. 98 No. 2 (2018): February

Section

Review

License

Copyright (c) 2018 Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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