FOXP3+ Atypical Cells in Poikilodermatous Mycosis Fungoides

Authors

  • Antonia Syrnioti
  • Aikaterini Patsatsi
  • Elisavet Georgiou
  • Chrysostomos Avgeros
  • Triantafyllia Koletsa Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece

DOI:

https://doi.org/10.2340/actadv.v102.2037

Keywords:

mycosis fungoides, tratment resistance, cutaneous lymphoma, T-cell lymphoma, immunohistochemistry

Abstract

Abstract is missing (Short communication)

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References

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https://doi.org/10.15570/actaapa.2015.10

Abbott RA, Sahni D, Robson A, Agar N, Whittaker S, Scarisbrick JJ. Poikilodermatous mycosis fungoides: A study of its clinicopathological, immunophenotypic, and prognostic features. J Am Acad Dermatol 2011; 65: 313-319.

https://doi.org/10.1016/j.jaad.2010.05.041

Jerković Gulin S, Čeović R, Ilić I, Bradamante M, Mokos ZB, Kostović K. Poikilodermatous mycosis fungoides - rare entity, different treatment modalities. Acta Dermatovenerologica Croat 2018; 26: 48-52.

Berg RV, Valente NYS, Fanelli C, Wu I, Pereira J, Zatz R, et al. Poikilodermatous mycosis fungoides: comparative study of clinical, histopathological and immunohistochemical features. Dermatology 2020; 236: 117-122.

https://doi.org/10.1159/000502027

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https://doi.org/10.1038/sj.leu.2404467

Klemke CD, Fritzsching B, Franz B, Kleinmann EV, Oberle N, Poenitz N, et al. Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas. Leukemia 2006; 20: 1123-1129.

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Gjerdrum LM, Woetmann A, Odum N, Burton CM, Rossen K, Skovgaard GL, et al. FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival. Leukemia 2007; 21: 2512-2518.

https://doi.org/10.1038/sj.leu.2404913

Berger CL, Tigelaar R, Cohen J, Mariwalla K, Trinh J, Wang N, et al. Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. Blood 2005; 105: 1640-1647.

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Krejsgaard T, Gjerdrum LM, Ralfkiaer E, Lauenborg B, Eriksen KW, Mathiesen AM, et al. Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome. Leukemia 2008; 22: 2230-2239.

https://doi.org/10.1038/leu.2008.224

Elhage R, Cheraï M, Levacher B, Darrasse-Jeze G, Baillou C, Zhao X, et al. C-terminal cleavage of human Foxp3 at a proprotein convertase motif abrogates its suppressive function. Scand J Immunol 2015; 81: 229-239.

https://doi.org/10.1111/sji.12275

Willerslev-Olsen A, Buus TB, Nastasi C, Blümel E, Gluud M, Bonefeld CM, et al. Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome. Blood Cancer J 2020; 10: 57.

https://doi.org/10.1038/s41408-020-0324-3

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https://doi.org/10.5114/ada.2020.95966

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Published

2022-05-04

How to Cite

Syrnioti, A., Aikaterini Patsatsi, Georgiou, E., Avgeros, C., & Koletsa, T. (2022). FOXP3+ Atypical Cells in Poikilodermatous Mycosis Fungoides. Acta Dermato-Venereologica, 102, adv00701. https://doi.org/10.2340/actadv.v102.2037

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